IgG4 positive lymphoplasmacytic inflammatory pseudotumour mimicking hepatocellular carcinoma.

JOURNAL ARTICLESCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe

Infective endocarditis presenting as an isolated aneurysm of the posterior mitral leaflet.

We describe the case of a 64-year-old woman in whom an aneurysm located on the posterior mitral leaflet was detected. Blood cultures grew methicillin-sensitive Staphylococcus epidermidis, and histologic examination of the operative specimen showed polymorphonuclear neutrophilic infiltration of the valve wall associated with fibrin and necrosis, consistent with a diagnosis of endocarditis. The posterior mitral location of the aneurysm and the absence of vegetation are exceptionally rare in this setting. This case demonstrates that a mitral aneurysm may be the sole cardiac presentation of infective endocarditis.Case ReportsJournal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe

A 63-Year-Old Woman with a Right Frontal Lesion

SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe

A 63-Year-Old Woman with a Right Frontal Lesion

SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe

Infarctus musculaire multifocal diabétique.

Diabetic muscle infarction is a rare and often unrecognized complication of diabetes. It typically occurs in patients with poorly controlled and multi-complicated diabetes. Typical clinical presentation is an indurate muscle pain, mainly localized in the lower limb with an acute onset. In most cases, diabetes myonecrosis is focal and sometimes can be recurrent. Diagnosis is clinical but can used magnetic resonance imaging (MRI). Muscle biopsy is sometimes necessary in cases of doubt or to confirm the imaging diagnosis. Elevation of muscle enzymes (CPK) is present in half of cases. Management is conservative and the clinical and imaging evolution is usually favourable. We report the case of a patient presenting a subacute hyperalgesic lomboradiculopathy.Case ReportsEnglish AbstractJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Data Sheet 1_Histological regression of peritoneal metastases of recurrent tubo-ovarian cancer after systemic chemotherapy.docx

IntroductionPost-treatment histological regression of peritoneal metastases (PM) is a new and potentially important predictor of oncological outcomes. Histology of PM from adnexal origin is usually evaluated by the Chemotherapy Response Score (CRS). The aim of this preliminary study was to quantify the response of PM of recurrent tubo-ovarian cancer (TOVC) after systemic chemotherapy by using the recently validated Peritoneal Regression Grading System (PRGS) and compare it with CRS. Correlation with per operative evaluation through Peritoneal Cancer Index (PCI) was performed.Material and methodsRetrospective cohort study of all consecutive patients with recurrent PM from TOVC undergoing surgery after prior systemic chemotherapy from January 2015 to March 2019. Biopsies were assessed with the four-scale PRGS.ResultsThirty-eight patients were included. Patients had a median of 2 (range 1–2) lines and 12 (range 3–18) cycles of prior systemic chemotherapy. Overall mean (SD) PRGS was 2.3 (±1.1). Of the patients, 26% (10) had complete response (PRGS 1), 40% (15) had major response (PRGS 2), 26% (10) minor response (PRGS 3), and 8% (3) had no response (PRGS 4). Mean PRGS was positively correlated with the Peritoneal Cancer Index (ρ = 0.5302, p = 0.0003) and inversely correlated with CRS (ρ = −0.8403, p ConclusionCRS and mean PRGS correlated with each other. Histological response of PM after systemic chemotherapy was quantifiable and variable. The role of PRGS for the evaluation of treatment response and as potential surrogate marker for oncological outcomes is part of ongoing and planned research.</p

Table 1_Histological regression of peritoneal metastases of recurrent tubo-ovarian cancer after systemic chemotherapy.docx

IntroductionPost-treatment histological regression of peritoneal metastases (PM) is a new and potentially important predictor of oncological outcomes. Histology of PM from adnexal origin is usually evaluated by the Chemotherapy Response Score (CRS). The aim of this preliminary study was to quantify the response of PM of recurrent tubo-ovarian cancer (TOVC) after systemic chemotherapy by using the recently validated Peritoneal Regression Grading System (PRGS) and compare it with CRS. Correlation with per operative evaluation through Peritoneal Cancer Index (PCI) was performed.Material and methodsRetrospective cohort study of all consecutive patients with recurrent PM from TOVC undergoing surgery after prior systemic chemotherapy from January 2015 to March 2019. Biopsies were assessed with the four-scale PRGS.ResultsThirty-eight patients were included. Patients had a median of 2 (range 1–2) lines and 12 (range 3–18) cycles of prior systemic chemotherapy. Overall mean (SD) PRGS was 2.3 (±1.1). Of the patients, 26% (10) had complete response (PRGS 1), 40% (15) had major response (PRGS 2), 26% (10) minor response (PRGS 3), and 8% (3) had no response (PRGS 4). Mean PRGS was positively correlated with the Peritoneal Cancer Index (ρ = 0.5302, p = 0.0003) and inversely correlated with CRS (ρ = −0.8403, p ConclusionCRS and mean PRGS correlated with each other. Histological response of PM after systemic chemotherapy was quantifiable and variable. The role of PRGS for the evaluation of treatment response and as potential surrogate marker for oncological outcomes is part of ongoing and planned research.</p

A simplified approach for the molecular classification of glioblastomas.

Glioblastoma (GBM) is the most common malignant primary brain tumors in adults and exhibit striking aggressiveness. Although GBM constitute a single histological entity, they exhibit considerable variability in biological behavior, resulting in significant differences in terms of prognosis and response to treatment. In an attempt to better understand the biology of GBM, many groups have performed high-scale profiling studies based on gene or protein expression. These studies have revealed the existence of several GBM subtypes. Although there remains to be a clear consensus, two to four major subtypes have been identified. Interestingly, these different subtypes are associated with both differential prognoses and responses to therapy. In the present study, we investigated an alternative immunohistochemistry (IHC)-based approach to achieve a molecular classification for GBM. For this purpose, a cohort of 100 surgical GBM samples was retrospectively evaluated by immunohistochemical analysis of EGFR, PDGFRA and p53. The quantitative analysis of these immunostainings allowed us to identify the following two GBM subtypes: the "Classical-like" (CL) subtype, characterized by EGFR-positive and p53- and PDGFRA-negative staining and the "Proneural-like" (PNL) subtype, characterized by p53- and/or PDGFRA-positive staining. This classification represents an independent prognostic factor in terms of overall survival compared to age, extent of resection and adjuvant treatment, with a significantly longer survival associated with the PNL subtype. Moreover, these two GBM subtypes exhibited different responses to chemotherapy. The addition of temozolomide to conventional radiotherapy significantly improved the survival of patients belonging to the CL subtype, but it did not affect the survival of patients belonging to the PNL subtype. We have thus shown that it is possible to differentiate between different clinically relevant subtypes of GBM by using IHC-based profiling, a method that is advantageous in its ease of daily implementation and in large-scale clinical application.Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Multivariate Analysis of Survival (Cox Proportional Hazards Regression Model) involving clinical variables and GBMs classification.

<p>The Model P-value indicates the overall level of significance of the multivariate model. Aside from “Age” which is a continuous variable, the other variables are binary. These variables distinguish between complete and partial resection, radiotherapy + temozolomide compared with radiotherapy alone, as well as the classification into the PNL subtype or into the CL subtype. The individual P-values represent the levels of significance of the independent contributions of each variable.</p><p>CI: confidence interval</p