The influence of household human and social capitals on participation in agricultural development initiatives in the coastal region of Kenya

The present study sought to establish the human and social capital that determines rural households’ participation in agricultural projects and programmes implemented by the Kenyan government and development partners. The research was carried out among rural households in the three counties of the coastal region of Kenya. Multi-stage sampling techniques (purposive, proportionate random and simple random sampling) were used to select the study area and the study sample. Data were collected using a semi-structured questionnaire, Focus Group Discussion and observation schedules. The data analysis was carried out using descriptive statistics and regression analysis with the help of the Statistical Package for Social Sciences Version 22. The findings revealed that individuals with human capital; namely age (-0.15), primary education (-0.16), secondary education (-0.14), vocational training (0.35), and on the of job training (0.25), have a higher likelihood of participating in agricultural development initiatives. Households with the social capital of membership to groups (0.51), engaged in economic activities (0.53) and have linkages with development agencies (0.44) have a higher likelihood of participating in development initiatives. Key policy recommendations for county government and development partners include: encourage the community members to enrol in adult education; provide support for vocational and technical training; register as members in existing groups or form groups based on common interest, and engage in economic activities. The county governments should enhance advisory services to ensure close contact with professionals who will facilitate training, meetings and interactions with groups leading to the empowerment of members

Perceived benefits and barriers to community participation in development projects – The case of Hazina ya Maendeleo ya Pwani on the Kenya coast

Benefits and barriers to participating in community development projects as perceived by participants were studied in coastal counties of Kenya through a World Bank-funded initiative known as Hazina ya Maendeleo ya Pwani (HMP). Primary data were collected from 326 randomly selected HMP beneficiaries using questionnaires. Data analysis using SPSS prioritized perceived benefits of participation as: acquisition of additional financial support (94 %); development of new skill (90.8 %); enhanced ability to meet own individual needs (90.8 %); development of valuable professional relationships (90.8 %); acquisition of useful knowledge (84.2 %); increased utilization of own expertise (77.9 %) heightened public profile (77.2 %); ability to contribute to community (71.9 %); ability to have greater impact (68.8 %); and enhanced ability to effect public policy (49.1 %). Perceived barriers were prioritized as: feeling unwelcome (89.4 %); lack of information or not knowing (87.9 %); feeling unable to make a difference (87.9 %); demanding work schedule at home or office (69.7 %); inadequate transportation (50.8 %); and concern for safety (43.2 %). The study concluded that while the perceived benefits still strengthen the argument for active involvement of communities, development practitioners need to incorporate “what’s in it for me?” as an incentive for participation in future. They should also develop context-specific strategies to overcome participation barriers

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Cooperative Problem-Based Learning (CPBL): a practical PBL model for engineering courses

Problem-Based Learning (PBL) is an inductive learning approach that uses a realistic problem as the starting point of learning. Unlike in medical education, which is more easily adaptable to PBL, implementing PBL in engineering courses in the traditional semester system set-up is challenging. While PBL is normally implemented in small groups of up to ten students with a dedicated tutor during PBL sessions in medical education, this is not plausible in engineering education because of the high enrollment and large class sizes. In a typical engineering course, implementation of PBL consisting of students in small groups in medium to large classes is more practical. However, this type of implementation is more difficult to monitor, and thus requires good support and guidance in ensuring commitment and accountability of each student towards learning in his/her group. To provide the required support, Cooperative Learning (CL) is identified to have the much needed elements to develop the small student groups to functional learning teams. Combining both CL and PBL results in a Cooperative Problem-Based Learning (CPBL) model that provides a step by step guide for students to go through the PBL cycle in their teams, according to CL principles. Suitable for implementation in medium to large classes (approximately 40-60 students for one floating facilitator), with small groups consisting of 3-5 students, the CPBL model is designed to develop the students in the whole class into a learning community. This paper provides a detailed description of the CPBL model. A sample implementation in a third year Chemical Engineering course, Process Control and Dynamics, is also described

Determinants of sustainability for community based water projects: the case of Hazina ya Maendeleo ya Pwani in coastal Kenya

Sustainability of development projects is considered essential for the continued delivery of services to beneficiary communities beyond external financing. However, various factors cause community projects to fail the sustainability test. This study investigated the determinants of sustainability for community-based water projects implemented through World Bank and Kenya Government financing known as Hazina ya Maendeleo ya Pwani. Research was conducted using sustainability criteria comprising social, organizational, technical and financial aspects that were selected based on literature review and community perceptions. The research was conducted in Kenya’s coastal region using data collected from 285 respondents. Frequencies, means and percentages were used to describe data while the Structural Equation Modeling technique determined factors influencing sustainability. Results illustrated that all the four indicators assessed predict sustainability. However, only the technical and financial indicators influence sustainability significantly. In conclusion, while it is important to incorporate all the four indicators during planning and designing of community-based water projects, special attention must focus on financial and technical aspects. The study recommends that building the capacity of Community Based Organizations in terms of technical competence and financial resources to support operation and maintenance is a requirement, rather than a choice, for sustainability of community-based water projects