Xenon excimer emission from pulsed high-pressure capillary microdischarges

Intense xenon vacuum ultraviolet (VUV) emission is observed from a high-pressure capillary cathode microdischarge in direct current operation, by superimposing a high-voltage pulse of 50 ns duration. Under stagnant gas conditions, the total VUV light intensity increases linearly with pressure from 400 to 1013 mbar for a fixed voltage pulse. At fixed pressure, however, the VUV light intensity increases superlinearly with voltage pulse height ranging from 0.8 to 2.8 kV. Gains in emission intensity are obtained by inducing gas flow through the capillary cathode, presumably because of excimer dimer survival due to gas cooling

Xenon excimer emission from multicapillary discharges in direct current mode

Microdischarges in xenon have been generated in a pressure range of 400–1013 mbar with a fixed flow rate of 100 sccm. These microdischarges are obtained from three metallic capillary tubes in series for excimer emission. Total discharge voltage is thrice as large as that of a single capillary discharge tube at current levels of up to 12 mA. Total spectral irradiance of vacuum ultraviolet (VUV) emission also increases significantly compared to that of the single capillary discharge. Further, the irradiance of the VUV emission is strongly dependent on pressure as well as the discharge current

Evaluation of Safety and Mobility Benefits of Connected and Automated Vehicles by Considering V2X Technologies

The recent development in communication technologies facilitates the deployment of connected and automated vehicles (CAV) which are expected to change the future transportation system. CAV technologies enable vehicles to communicate with other vehicles through vehicle-to-vehicle (V2V) communications and the infrastructure through Vehicle-to-infrastructure (V2I) communications. Since the real-world CAV data is not currently available as of today, simulation is the most commonly used platform to evaluate the future V2X system. Although several studies evaluated the effectiveness of CAVs in a small roadway network, there is a lack of studies analyzing the impact of CAVs at the network level by considering both freeways and arterials. Also, none of the previous studies have attempted to differentiate the benefits of CAVs over only automated vehicles (AVs) by incorporating multiple preceding vehicles\u27 information (i.e., acceleration, position, etc.). On the other hand, most of the simulation-based studies assumed the uninterrupted communication between vehicles in the CAV environment which might not be feasible in reality. Hence, there is still a research gap that exists for which this study tried to fill this gap. Therefore, this study developed a calibrated and validated large-scale network for the deployment of CAV technologies by utilizing Dynamic Traffic Assignment (DTA) model in Orlando metropolitan area, Florida, using Multi-Resolution Modeling (MRM) technique. Also, the study proposed a signal control algorithm through V2I technology in order to elevate the performance of CAVs at intersections. Different car-following models were utilized to approximate different CAV technologies (CAV, AV, and CV (connected vehicle)) in the simulation environment. Hence, the study analyzed the benefits of CAV over AV with different market penetration rates (MPRs). Furthermore, the study considered the performance of different communication system along with the traffic condition by utilizing Dedicated Short-Range Communications (DSRC or IEEE 802.11p) and wireless access (IEEE 1609 protocol) for the application of vehicle ad-hoc network (VANET). To this end, the study evaluated the safety effectiveness of different communication protocols under the CAV environment. Aimsun Next and SUMO & OMNET++ based Veins simulator were used as the simulation platform. Different car-following models, signal control algorithm, and communication systems were coded by using the application programming interface (API) and C++ language. For the traffic efficiency, the study utilized travel time and travel time rate (TTR) while for the safety evaluation, different surrogate safety measures; speed, and crash-risk models were used. Also, several statistical tests (e.g., t-test, ANOVA) and modeling techniques (e.g., generalized estimating equation, logistic regression, etc.) were developed to analyze both safety and mobility. The results of this study implied that CAV could improve both safety and efficiency at the network level with different MPRs. Also, CAV is more efficient compared to the only AV in terms of both traffic safety and mobility. Different communication protocols have a significant effect on traffic safety under the CAV environment. Finally, the results of this study provide insight to transportation planners and the decision makers about the benefits of CAV at the network level, different CAV technologies, and the performance of different communication systems under the CAV environment

Improving Traffic Safety at School Zones by Engineering and Operational Countermeasures

Safety issues at school zone areas have been one of the most important topics in the traffic safety field. Although many studies have evaluated the effectiveness of various traffic control devices (e.g., sign, flashing beacon, speed monitoring display), there is a lack of studies exploring different roadway countermeasures and the relationship between school-related factors and crashes. In this study, the most crash-prone school zone was identified in Orange and Seminole Counties, Florida, based on crash rate. Afterward, a microsimulation network was built in VISSIM environment to test different roadway countermeasures in the school zones. Three different countermeasures: two-step speed reduction (TSR), decreasing the number of driveways (DD), and replacing the two-way left-turn lane (TWLTL) to the raised median (RM) were implemented in the microsimulation. Three surrogate safety measures-: (1) time exposed time to collision (TET), (2) time integrated time to collision (TIT) and (3) time exposed rear-end crash risk index (TERCRI) were utilized in this study as indicators for safety evaluation. The higher value of surrogate safety measures indicates higher crash risk. The results showed that both TSR and DD reduced TET, TIT and TERCRI values significantly compare to the base condition. Moreover, the combination of TSR and DD countermeasures outperformed their individual effectiveness. The One-way ANOVA analysis showed that all the sub-scenarios were significantly different from each other. Sensitivity analysis result has proved that all the sub-scenarios in TSR and DD reduced TET, TIT and TERCRI values significantly for different value of TTC threshold. On the other hand, for converting the TWLTL to RM, the crash risk was higher than the base condition because of the turning movements of vehicle. The results of this study could help transportation planners and decision makers to understand the effect of these countermeasures to improve safety at school zones

Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin

Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It has a long history of traditional medicinal use by the Native Americans and Mexicans. The modulatory effects of topically applied NDGA was studied on acute inflammatory and oxidative stress responses in mouse skin induced by stage I tumor promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA). Double TPA treatment adversely altered many of the marker responses of stage I skin tumor promotion cascade. Pretreatment of NDGA in TPA-treated mice mitigated cutaneous lipid peroxidation and inhibited production of hydrogen peroxide. NDGA treatment also restored reduced glutathione level and activities of antioxidant enzymes. Elevated activities of myeloperoxidase, xanthine oxidase and skin edema formation in TPA-treated mice were also lowered by NDGA indicating a restrained inflammatory response. Furthermore, results of histological study demonstrated inhibitory effect of NDGA on cellular inflammatory responses. This study provides a direct evidence of antioxidative and anti-inflammatory properties of NDGA against TPA-induced cutaneous inflammation and oxidative stress corroborating its chemopreventive potential against skin cancer

Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811

Pulmonary complications after liver transplantation (LT) often cause mortality. This study investigated whether small-for-size LT increases acute pulmonary injury and whether NIM811 which improves small-for-size liver graft survival attenuates LT-associated lung injury. Rat livers were reduced to 50% of original size, stored in UW-solution with and without NIM811 (5 μM) for 6 h, and implanted into recipients of the same or about twice the donor weight, resulting in half-size (HSG) and quarter-size grafts (QSG), respectively. Liver injury increased and regeneration was suppressed after QSG transplantation as expected. NIM811 blunted these alterations >75%. Pulmonary histological alterations were minimal at 5–18 h after LT. At 38 h, neutrophils and monocytes/macrophage infiltration, alveolar space exudation, alveolar septal thickening, oxidative/nitrosative protein adduct formation, and alveolar epithelial cell/capillary endothelial apoptosis became overt in the lungs of QSG recipients, but these alterations were mild in full-size and HSG recipients. Liver pretreatment with NIM811 markedly decreased pulmonary injury in QSG recipients. Hepatic TNFα and IL-1β mRNAs and pulmonary ICAM-1 expression were markedly higher after QSG transplantation, which were all decreased by NIM811. Together, dysfunctional small-for-size grafts produce toxic cytokines, leading to lung inflammation and injury. NIM811 decreased toxic cytokine formation, thus attenuating pulmonary injury after small-for-size LT