Disease modification trials in parkinsons disease: A Review

Among the common neurological disorders worldwide, Parkinson’s disease has a major share. Currently, only symptomatic therapies are available for it without any approved neuromodulation drugs as all the previously done disease modification trials have failed. There is a dire need for such therapies. Disease modification trials include all types of intervention targeting the degeneration process which underlies the disease process and thus slows it down or the treatment aim to regenerate or replace the neurons which are lost. There are many reasons for the failure of trials. This review emphasize the need for disease modification trials, causes of failure of trials, few prominent previously failed trails and review on-going clinical trials for disease modification. The aim of this review article is to highlight the importance and utmost need of development of neuroprotective agents for Parkinson’s disease through future research

A case report of joubert syndrome in adult presenting with seizures

Joubert syndrome (JS) is rare autosomal recessive condition characterized by hypotonia, ataxia, psychomotor delay, and variable occurrence of oculomotor apraxia and neonatal breathing abnormalitie,intellectual disability, and specific mid-hindbrain malformation (“molar tooth sign”, MTS) We reportthe case of Joubert syndrome in a 32 years old female patient presenting with intellectual impairment, breathing abnormal breathing patterns like tachypnea followed by apnea ataxia, and seizures. She was diagnosed on the basis of Magnetic Resonance Imaging (MRI) and clinical features. JoubertSyndrome should be considered in all patients presenting with hypotonia, ataxia, nystagmus, breathing abnormalities and developmental delay. Its neuroimaging hallmarks include molar tooth sign and batwing shaped fourth ventricle.Joubert syndrome and related disorders (JSRD) refers to individuals who have JS with additional findings such as eye, renal and hepatic problems. As JS is associated with multiorgan involvement, these patients should enter a diagnostic protocol to assess systemic abnormalities. Extreme caution should be taken while administering drugs in these patients as they are prone to respiratory depression.Early diagnosis of Joubert syndrome and related disorders (JSRD) is important for rehabilitation programmes, prognostic outcome and genetic consultation. Close follow-up is also necessary to identify potential complications of the diseas

Movement disorder associated with celiac disease and thyroid dysfunction:case report

Autoimmune movement disorders are uncommon yet likely treatable conditions. It is challenging to diagnose and manage these disorders, ultimately leading to a significant morbidity in terms of functional disability of patient. It is troublesome for practicing neurologists to identify whether the antibodies which are detected during the work up of these autoimmune movement disorders are merely incidental or have pathogenic role. This will help them to decide regarding whether to start immunotherapy or not. Here we have discussed two patients of movement disorder who were found to have positive work up for other autoimmune diseases. Available Literature on autoimmune movement disorder is very limited and further research on large scale is needed

Pregabalin Induced Hypersensitivity Reaction and Joint Pains in Patient with Lumbosacral Radiculopathy

Pregabalin is an antiepileptic medication commonly used for other purposes. It is also approved for neuropathic pain. Reported adverse effects are not severe, short lasting and are usually well tolerated1. The most common side effects comprise of lightheadedness , sedation , double vision ,increase in bodyweight and imbalance whereas decrease in neutrophil count and hypersensitivity are the uncommon adverse effects. In the literature till date, few case reports are available on the drug reactions to pregabalin. We report a case of young female who developed hypersensitivity reaction with pregabalin including body rashes, hives peripheral edema, and joint pains. Using the Naranjo Adverse Drug Reaction Probability Scale, a ‘‘probable’’ reaction (Score: 7) was attributed to our patient. Clinicians should keep in mind the reported side effects and counsel patient about the possible side effects before starting it with regular follow up of patients for side effects monitoring

How children perceive COVID-19? Kids drawings and perceptions of parents

COVID-19 affected many lives, number of children become stressful and socially isolated. School closure also has great impact on children’s social-emotional development and overall wellbeing. The aim of current study was to identify children’s reactions to COVID-19 and its impact on academic and social life. Qualitative participatory research design was used to assess children perception about COVID-19. Data were collected from parent’s interview and Children drawing. Three major themes include: Fear of the drastic changes, increased sense of responsibility, and gratitude for being at home with family was reported by the parents however children drawings revealed that most of the children felt unhappy and sad because of lock down they were missing things they were missing enjoyed earlier such as school, fiends and outdoor activities and games. This is astonished that most of the children drawn the COVID-19 virus and represented as giant and ugly. Few children also draw mask and other protective measures. Public awareness program on COVID-19 protection and mental health promotion of will be window of opportunity for children psychosocial wellbeing