Branes and fluxes in special holonomy manifolds and cascading field theories

We conduct a study of holographic RG flows whose UV is a theory in 2+1 dimensions decoupled from gravity, and the IR is the N=6,8 superconformal fixed point of ABJM. The solutions we consider are constructed by warping the M-theory background whose eight spatial dimensions are manifolds of special holonomies sp(1) times sp(1) and spin(7). Our main example for the spin(7) holonomy manifold is the A8 geometry originally constructed by Cvetic, Gibbons, Lu, and Pope. On the gravity side, our constructions generalize the earlier construction of RG flow where the UV was N=3 Yang-Mills-Chern-Simons matter system and are simpler in a number of ways. Through careful consideration of Page, Maxwell, and brane charges, we identify the discrete and continuous parameters characterizing each system. We then determine the range of the discrete data, corresponding to the flux/rank for which the supersymmetry is unbroken, and estimate the dynamical supersymmetry breaking scale as a function of these data. We then point out the similarity between the physics of supersymmetry breaking between our system and the system considered by Maldacena and Nastase. We also describe the condition for unbroken supersymmetry on class of construction based on a different class of spin(7) manifolds known as B8 spaces whose IR is different from that of ABJM and exhibit some interesting features.Comment: 51 pages, 12 figures. Update in quantization of G4 on B8 in equations (5.12) and (5.13

Mesonic Chiral Rings in Calabi-Yau Cones from Field Theory

We study the half-BPS mesonic chiral ring of the N=1 superconformal quiver theories arising from N D3-branes stacked at Y^pq and L^abc Calabi-Yau conical singularities. We map each gauge invariant operator represented on the quiver as an irreducible loop adjoint at some node, to an invariant monomial, modulo relations, in the gauged linear sigma model describing the corresponding bulk geometry. This map enables us to write a partition function at finite N over mesonic half-BPS states. It agrees with the bulk gravity interpretation of chiral ring states as cohomologically trivial giant gravitons. The quiver theories for L^aba, which have singular base geometries, contain extra operators not counted by the naive bulk partition function. These extra operators have a natural interpretation in terms of twisted states localized at the orbifold-like singularities in the bulk.Comment: Latex, 25pgs, 12 figs, v2: minor clarification

Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries

Background: Pancreatic surgery remains associated with high morbidity rates. Although postoperative mortality appears to have improved with specialization, the outcomes reported in the literature reflect the activity of highly specialized centres. The aim of this study was to evaluate the outcomes following pancreatic surgery worldwide.Methods: This was an international, prospective, multicentre, cross-sectional snapshot study of consecutive patients undergoing pancreatic operations worldwide in a 3-month interval in 2021. The primary outcome was postoperative mortality within 90 days of surgery. Multivariable logistic regression was used to explore relationships with Human Development Index (HDI) and other parameters.Results: A total of 4223 patients from 67 countries were analysed. A complication of any severity was detected in 68.7 percent of patients (2901 of 4223). Major complication rates (Clavien-Dindo grade at least IIIa) were 24, 18, and 27 percent, and mortality rates were 10, 5, and 5 per cent in low-to-middle-, high-, and very high-HDI countries respectively. The 90-day postoperative mortality rate was 5.4 per cent (229 of 4223) overall, but was significantly higher in the low-to-middle-HDI group (adjusted OR 2.88, 95 per cent c.i. 1.80 to 4.48). The overall failure-to-rescue rate was 21 percent; however, it was 41 per cent in low-to-middle-compared with 19 per cent in very high-HDI countries.Conclusion: Excess mortality in low-to-middle-HDI countries could be attributable to failure to rescue of patients from severe complications. The authors call for a collaborative response from international and regional associations of pancreatic surgeons to address management related to death from postoperative complications to tackle the global disparities in the outcomes of pancreatic surgery (NCT04652271; ISRCTN95140761)