Gaze Guidance Using a Facial Expression Robot

This paper describes the gaze guidance with emotional expression of a head robot, called Kamin-FA1. We propose to use not only the gaze control of the robot, but also the facial expression to guide a human being's gaze to the target. We provide the information of the target of gaze intuitively to the human based on joint attention with Kamin-FA1. The robot has a facial expression function using a curved surface display. We examined the effect of emotional expression on the gaze guidance in terms of the accuracy and reaction speed. We conducted experiments of human gaze measurement during the gaze guidance with emotional expression to evaluate the role of emotional expression. The results of the gaze guidance experiments showed that gaze guidance with emotional expression caused a more accurate and quicker response than that without emotional expression. In particular, the expression of surprise has better performance in the gaze guidance compared with the normal expression. Furthermore, emotional expressions of angry and surprise impressed the subjects in dangerous situations, while normal and happy situations gave the impression of a safe situation at the target of gaze.Advanced robotics. 23(14):1831-1848 (2009)journal articl

A Development of the Building Kansei Information Retrieval System

The purpose of this research is to develop the method to retrieve a building name from the impression of the building. First, the images of the building are registered as database by the questionnaire. Next, the images of the objective building are compared with the degree of matching in image databases, and the building with high synthetic matching degree is retrieved. This system could get a good retrieval result. Moreover, image processing was done, and image databases are trained by neural network from the amount of characteristics of the image, and the retrieval system by image processing was examined

Molecular identification of non-conventional yeasts and the screening for α-terpineol assimilation: Identificação molecular de leveduras não convencionais e triagem para assimilação de α-terpineol

The present research aimed to analyze the potential consumption of a monoterpene compound, α-terpineol, by aroma-producing Yeasts. For this purpose, 23 non-conventional yeasts were selected and identified by molecular tools. Subsequently, a screening test was performed to evaluate their tolerance to α-terpineol, by cultivating them in YM broth, at pH 5.0, for 48 h. A mixture of α-terpineol and ethyl alcohol was added to the broth in concentrations ranging from 2.5 to 10.0 μL/mL (intervals of 2.5). The yeasts that survived any of these concentrations were cultured again, but this time in mineral DP liquid culture medium to assess the consumption of α-terpineol. TLC analysis was conducted to analyze the consumption of α-terpineol. The yeasts studied were identified as Clavispora lusitaniae (n=12), Rhodotorula mucilaginosa (n=8), and Lodderomyces elongisporus (n=3). Furthermore, according to the phylogenetic tree, two of these strains (C. lusitaniae and L. elongisporus) have greater genetic proximity than the yeast R. mucilaginosa. From the 23 yeasts, 6 of them were shown to be tolerant to the concentration of 2.5 μL/mL of α-terpineol. The tolerant strains were identified as C. lusitaniae (n = 1), L. elongisporus (n = 2), and R. mucilaginosa (n = 3). However, the yeast that resisted the highest concentration, R. mucilaginosa, was only 12 hours in all concentrations. It is more likely that the defense mechanism of the yeast was not able to prevent further damage to the membrane as the time in contact with α-terpineol increased. The TLC results showed that the extracts from R. mucilaginosa (CMRP3205) and L. elongisporus (CMRP3192) could be interpreted as potentially promising results of new compounds production by the yeasts

Solitary Fibrous Tumor of the Prostate Which Was Initially Misdiagnosed as Prostate Cancer

Solitary fibrous tumor (SFT) of the prostate is a very rare tumor. We report a case of 65-year-old man with SFT of the prostate which was initially misdiagnosed as prostate cancer. Finally, we performed total prostatectomy and the tumor was histologically diagnosed as SFT of the prostate. The patient’s clinical course has progressed favorably with no obvious recurrence 18 months postoperatively

Reactivity of CA19-9 and CA125 in Histological Subtypes of Epithelial Ovarian Tumors and Ovarian Endometriosis

Previous reports have shown that some ovarian endometrioid adenocarcinomas and ovarian clear cell adenocarcinomas derive from ovarian endometriosis (OE), and that endocervical-like mucinous borderline ovarian tumors are associated with OE. We examined the relationship between the staging and histological subtypes of OE or epithelial ovarian tumors (EOT) and the serum levels of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) to evaluate the potential of these markers for preoperative diagnosis. First, we analyzed the preoperative serum levels of CA19-9 and CA125 in 195 patients who were histopathologically diagnosed with OE or EOT. We then performed a case-control study in which 308 women were enrolled, the 195 women described above and 113 healthy women as control subjects. Serum CA19-9 and CA125 levels were found to be useful in differentiating between OE and serous adenocarcinoma, but not between OE and other EOT. Moreover, serum CA19-9 levels were useful for preoperative assessment between OE and stage I mucinous borderline ovarian tumors, with or without the interstitial infiltration. In addition, considering that the serum CA19-9 levels in stage I mucinous borderline ovarian tumors were elevated via the interstitial infiltration of leukocytes and that precancerous lesions are associated with a cancerous glycosylation disorder in the process of inflammatory carcinogenesis, the CA19-9 level may be considered a suitable biomarker for estimating drug susceptibility

Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator

AbstractThe phenotypes of mice carrying clock gene mutations have been critical to understanding the mammalian clock function. However, behavior does not necessarily reflect cell-autonomous clock phenotypes, because of the hierarchical dominance of the central clock. We performed cell-based siRNA knockdown and cDNA overexpression and monitored rhythm using bioluminescent reporters of clock genes. We found that knockdown of DBP, D-box positive regulator, in our model led to a short-period phenotype, whereas overexpressing of DBP produced a long-period rhythm when compared to controls. Furthermore, knockdown and overexpressing of E4BP4, D-box negative regulator, led to an opposite effect of DBP. Our experiments demonstrated that D-box regulators play a crucial role in determining the period length of Per1 and Per2 promoter-driven circadian rhythms in Rat-1 fibroblasts

A Case of Primary Cutaneous Basal Cell Carcinosarcoma

A 94-year-old man consulted our hospital due to a rapidly growing tumor on the left cheek. The histological diagnosis of the tumor was basal cell carcinosarcoma, which was composed of intermingled epithelial and mesenchymal components. The former was basal cell carcinoma, while the latter was spindle cell sarcoma. The tumor was completely resected with a 3-mm margin and the patient remained free of local recurrence or distinct metastasis for 2 years. We report here a case of cutaneous basal cell carcinosarcoma and a review of the literature

Bullous Pemphigoid IgG Induces BP180 Internalization via a Macropinocytic Pathway

Bullous pemphigoid (BP) is an autoimmune blistering skin disease induced by pathogenic autoantibodies against a type II transmembrane protein (BP180, collagen type XVII, or BPAG2). In animal models, BP180 autoantibody-antigen interaction appears insufficient to develop blisters, but involvement of complement and neutrophils is required. However, cultured keratinocytes treated with BP-IgG exhibit a reduction in the adhesive strength and a loss of expression of BP180, suggesting that the autoantibodies directly affect epidermal cell–extracellular matrix integrity. In this study, we explored the consequences of two distinct epithelial cells treated with BP-IgG, particularly the fate of BP180. First, we followed the distribution of green fluorescent protein–tagged BP180 in an epithelial cell line, 804G, and normal human epidermal keratinocytes after autoantibody clustering. After BP-IgG treatment, the adhesive strength of the cells to their substrate was decreased, and BP180 was internalized in both cell types, together with the early endosomal antigen-1. By using various endocytosis inhibitors and a fluid-uptake assay, we demonstrated that BP-IgG–induced BP180 internalization is mediated via a macropinocytic pathway. Moreover, a macropinocytosis inhibitor rescued a BP-IgG–induced reduction in the adhesive strength of the cells from their substrate. The results of this study suggest that BP180 internalization induced by BP-IgG plays an important role in the initiation of disease pathogenesis