Seborrheic keratoses: a distinctive diagnoses of pigmented vulvar lesions: a case report

Seborrheic keratoses, a benign growth lesion, is a very common cutaneous lesion encountered in white races in the fourth and fifth decade. The occurrence of this lesion on the vulva is rare, as an isolated lesion or in association with lesions elsewhere. A 34-year-old woman reported with a hyperpigmented palpable lesion, approximately 5-10 mm in diameter, was found on the patient's left labium majus. The clinical differential diagnosis of the pigmented lesions of the vulva is difficult often need a biopsy

Results of the COVID-19 mental health international for the general population (COMET-G) study.

INTRODUCTION: There are few published empirical data on the effects of COVID-19 on mental health, and until now, there is no large international study. MATERIAL AND METHODS: During the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 ± 13.61; 34.05% males aged 34.90±13.29 and 1.10% other aged 31.64±13.15). Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively. STATISTICAL ANALYSIS: Descriptive statistics were calculated. Chi-square tests, multiple forward stepwise linear regression analyses and Factorial Analysis of Variance (ANOVA) tested relations among variables. RESULTS: Probable depression was detected in 17.80% and distress in 16.71%. A significant percentage reported a deterioration in mental state, family dynamics and everyday lifestyle. Persons with a history of mental disorders had higher rates of current depression (31.82% vs. 13.07%). At least half of participants were accepting (at least to a moderate degree) a non-bizarre conspiracy. The highest Relative Risk (RR) to develop depression was associated with history of Bipolar disorder and self-harm/attempts (RR = 5.88). Suicidality was not increased in persons without a history of any mental disorder. Based on these results a model was developed. CONCLUSIONS: The final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress. This could be of practical utility since many of these factors are modifiable. Future research and interventions should specifically focus on them

AA 2024 Al ALAŞIMININ SÜRTÜNME KARIŞTIRMA KAYNAĞINDA (SKK) KAYNAK PARAMETRELERİNİN BİRLEŞMEYE ETKİLERİNİN İNCELENMESİ

Bu çalışmada sürtünme karıştırma kaynağı yöntemiyle birleştirilen AA2024 alüminyum levhaların kaynak bölgelerinin değişik parametrelerle mikroyapı ve mekanik özellikleri incelenmiştir. Sürtünme karıştırma kaynak yöntemi teknolojiyle beraber gelişimi sürekli devam eden ve kaynak dünyası içinde doksanlı yıllarda kullanılmaya başlanan bir katı hal kaynak yöntemidir. Birçok yönden sağladığı üstünlükler ile özellikle günümüzde alüminyum ve alüminyum alaşımlarının kaynağında yaygın bir biçimde kullanılmaktadır. Kaynak işlemi sırasında karıştırıcı ucun devir hızı, karıştırıcı ucun omuz genişliği ve kaynağın ilerleme hızı değişken parametreler olarak seçilmiştir. Karıştırıcı ucun devir sayısı sabitken kaynak ilerleme hızı farklı değerde seçilmiş ve kaynak ilerleme hızı sabitken de karıştırıcı uç devir sayısı değiştirilmiştir. Bu işlemler üç ayrı omuz genişliğinde de tekrarlanmıştır. Kaynaklı birleştirmelerde metalografik ve mekanik testler yapılarak kaynak ilerleme ve karıştırıcı uç devir sayısı değişimin, birleşme bölgesinin metalürjik ve mekanik özellikleri üzerindeki etkileri araştırılmıştır.In this study, the microstructure of aluminium sheets with different parameter which were joined through stir friction welding were examined. The way of stir friction welding, started to use in 1990's, is a solid phase way and is continiously developing with technology. Especially today, because of its superiorities with many sides, stir friction welding is used for aluminium and its alloys' welding. During welding, rotatinal speed of welding stir tool, the shoulder width of welding stir tool and welding speed were chosen asvariable parameters. While rotational speed of welding stir tool was constant, welding speed was chosen in a different speed and while welding speed was constant, the rotational speed of welding stir tool was chosen in different speed. These were repeated for all three shoulder widths. Through metallographic and mechanic tests on welding, the influences of different speed of welding and rotational welding speed on metallurgy and mechanic properties of junction section were examined

Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF

The Fas-Fas Ligand interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of infertility causing diseases in women and has been suggested as one of the important factors that negatively affect IVF outcome. In this study, our aim was to evaluate serum and follicular fluid levels of soluble Fas soluble Fas Ligand, malondialdehyde, superoxide dismutase and total antioxidant capacity in patients undergoing IVF and compared with controls. This study included 109 patients. Patients were classified as unexplained infertility (N = 31), PCOS (N = 19), tubal factor (N = 9) and endometriosis (N = 10) and compared with male factor infertility (N = 40) that was the control group. sFas and sFasL levels were measured by immunoassay method. MDA, SOD and TAC levels were measured by colorimetric method. Patients with unexplained infertility, PCOS and tubal factor had significantly lower sFas levels compared with their controls (respectively, p < 0.01, p < 0.05, p < 0.05). However, SOD activity in unexplained infertility, PCOS and endometriosisgroupswere significantly higher than control group (p < 0.01).Decreased follicular fluid TAC levels were found in all patient groups compared with controls (respectively, p < 0.01, p < 0.05, p < 0.01, p < 0.01).Patients with tubal factor had significantly higher serum sFasL (p < 0.05), but lower follicular fluid sFasL levels (p < 0.05) compared with unexplained infertility. Tubal factor and endometriosis groups had lowerfollicular fluid TAC levels compared to unexplained infertility and PCOSgroups (p < 0.01). In this study, serum and follicular fluid sFas levels were decreased and antioxidant activity was impaired in infertility, possibly implying increased apoptosis. Especially in unexplained infertility group changes in this parametres more remarkable

Oxidant/antioxidant status in premenstrual syndrome

To investigate oxidant/antioxidant status in premenstrual syndrome (PMS)