477 research outputs found
Evidence for a persistent, major excess in all cause admissions to hospital in children with type-1 diabetes: results from a large Welsh national matched community cohort study
OBJECTIVES: To estimate the excess in admissions associated with type1 diabetes in childhood. DESIGN: Matched-cohort study using anonymously linked hospital admission data. SETTING: Brecon Group Register of new cases of childhood diabetes in Wales linked to hospital admissions data within the Secure Anonymised Information Linkage Databank. POPULATION: 1577 Welsh children (aged between 0 and 15â
years) from the Brecon Group Register with newly-diagnosed type-1 diabetes between 1999â2009 and 7800 population controls matched on age, sex, county, and deprivation, randomly selected from the local population. MAIN OUTCOME MEASURES: Difference in all-cause hospital admission rates, 30-days post-diagnosis until 31 May 2012, between participants and controls. RESULTS: Children with type-1 diabetes were followed up for a total of 12â
102 person years and were at 480% (incidence rate ratios, IRR 5.789, (95% CI 5.34 to 6.723), p<0.0001) increased risk of hospital admission in comparison to matched controls. The highest absolute excess of admission was in the age group of 0â5â
years, with a 15.4% (IRR 0.846, (95% CI 0.744 to 0.965), p=0.0061) reduction in hospital admissions for every 5-year increase in age at diagnosis. A trend of increasing admission rates in lower socioeconomic status groups was also observed, but there was no evidence of a differential rate of admissions between men and women when adjusted for background risk. Those receiving outpatient care at large centres had a 16.1% (IRR 0.839, (95% CI 0.709 to 0.990), p=0.0189) reduction in hospital admissions compared with those treated at small centres. CONCLUSIONS: There is a large excess of hospital admissions in paediatric patients with type-1 diabetes. Rates are highest in the youngest children with low socioeconomic status. Factors influencing higher admission rates in smaller centres (eg, âout of hours resourcesâ) need to be explored with the aim of targeting modifiable influences on admission rates
Gravitino constraints on models of neutrino masses and leptogenesis
In the supersymmetric extensions of the standard model, neutrino masses and
leptogenesis requires existence of new particles. We point out that if these
particles with lepton number violating interactions have standard model gauge
interactions, then they may not be created after reheating because of the
gravitino problem. This will rule out all existing models of neutrino masses
and leptogenesis, except the one with right-handed singlet neutrinos.Comment: 12 pages latex file with one postscript figur
Coastal agricultural landscapes: Mapping and understanding grazing intensity on Welsh saltmarshes
Coastal wetlands such as saltmarshes support local communities and industries through ecosystem services and benefit the well-being of local communities in many regions of the world. Along sheltered temperate and sub-tropical coastlines, saltmarshes provide coastal protection, provision of recreational space and wildlife habitat. Those in northwest Europe provide a valuable resource for local agricultural communities through livestock grazing. Following the departure of the UK from the EU and the related potential changes to agricultural policies and markets, it is timely to evaluate the status of saltmarsh livestock grazing. In particular, knowledge of grazing patterns, policy futures and stakeholder perceptions are required to support traditional cultural practice and the ecological status of saltmarshes. This study focuses on the devolved UK nation of Wales, as it has a strong traditional agricultural and pastoral economy, and a landscape of significant conservation value. Yet there are substantial evidence and knowledge gaps regarding livestock grazing and its saltmarsh impact. We present the first map showing the spatial distribution of saltmarsh grazing practice in the UK. Drawing on insights gathered through an expert workshop and interviews with saltmarsh landowners and managers across Wales (N = 35), the paper discusses the challenges and benefits of coastal grazing on saltmarshes, highlighting the diverse values, personal connection and sense of identity associated with marshes. Interviews reveal deep rooted social and cultural values attributed to saltmarshes by the rural coastal community. The study illustrates the need for an integrated approach to management of saltmarshes, accounting for the social, cultural, economic, and environmental values within decision-making
Vibrationally quantum-state-specific reaction dynamics of H atom abstraction by CN radical in solution
Protecting the primordial baryon asymmetry in the seesaw model compatible with WMAP and KamLAND
We require that the primordial baryon asymmetry is not washed out in the
seesaw model compatible with the recent results of WMAP and the neutrino
oscillation experiments including the first results of KamLAND. We find that
only the case of the normal neutrino mass hierarchy with an approximate
-symmetry satisfies the requirement. We further derive, depending on the
signs of neutrino mass eigenvalues, three types of neutrino mass matrixes,
where the values of each element are rather precisely fixed.Comment: 21pages; added reference
Model for fermion mass matrices and the origin of quark-lepton symmetry
Several phenomenological features of fermion masses and mixings can be
accounted for by a simple model for fermion mass matrices, which suggests an
underlying U(2) horizontal symmetry. In this context, it is also proposed how
an approximate quark-lepton symmetry can be achieved without unified gauge
theories.Comment: 12 pages, RevTex. Minor changes, some references adde
Sensitivity of the g-mode frequencies to pulsation codes and their parameters
From the recent work of the Evolution and Seismic Tools Activity (ESTA,
Lebreton et al. 2006; Monteiro et al. 2008), whose Task 2 is devoted to compare
pulsational frequencies computed using most of the pulsational codes available
in the asteroseismic community, the dependence of the theoretical frequencies
with non-physical choices is now quite well fixed. To ensure that the accuracy
of the computed frequencies is of the same order of magnitude or better than
the observational errors, some requirements in the equilibrium models and the
numerical resolutions of the pulsational equations must be followed. In
particular, we have verified the numerical accuracy obtained with the Saclay
seismic model, which is used to study the solar g-mode region (60 to
140Hz). We have compared the results coming from the Aarhus adiabatic
pulsation code (ADIPLS), with the frequencies computed with the Granada Code
(GraCo) taking into account several possible choices. We have concluded that
the present equilibrium models and the use of the Richardson extrapolation
ensure an accuracy of the order of in the determination of the
frequencies, which is quite enough for our purposes.Comment: 10 pages, 5 figures, accepted in Solar Physic
Leptogenesis and neutrino parameters
We calculate the baryonic asymmetry of the universe in the
baryogenesis-via-leptogenesis framework, assuming first a quark-lepton symmetry
and then a charged-neutral lepton symmetry. We match the results with the
experimentally favoured range. In the first case all the oscillation solutions
to the solar neutrino problem, except the large mixing matter solution, can
lead to the allowed range, but with fine tuning of the parameters. In the
second case the general result is quite similar. Some related theoretical hints
are discussed.Comment: RevTex, 21 pages with 8 figure
Four Light Neutrinos in Singular Seesaw Mechanism with Abelian Flavor Symmetry
The four light neutrino scenario, which explains the atmosphere, solar and
LSND neutrino experiments, is studied in the framework of the seesaw mechanism.
By taking both the Dirac and Majorana mass matrix of neutrinos to be singular,
the four neutrino mass spectrum consisting of two almost degenerate pairs
separated by a mass gap eV is naturally generated. Moreover the
right-handed neutrino Majorana mass can be at GeV scale unlike
in the usual singular seesaw mechanism. Abelian flavor symmetry is used to
produce the required neutrino mass pattern. A specific example of the flavor
charge assignment is provided to show that maximal mixings between the
and are respectively attributed to the
atmosphere and solar neutrino anomalies while small mixing between two pairs to
the LSND results. The implication in the other fermion masses is also
discussed.Comment: Firnal version to appear in PR
Seesaw mechanism, baryon asymmetry and neutrinoless double beta decay
A simplified but very instructive analysis of the seesaw mechanism is here
performed. Assuming a nearly diagonal Dirac neutrino mass matrix, we study the
forms of the Majorana mass matrix of right-handed neutrinos, which reproduce
the effective mass matrix of left-handed neutrinos. As a further step, the
important effect of a non diagonal Dirac neutrino mass matrix is explored. The
corresponding implications for the baryogenesis via leptogenesis and for the
neutrinoless double beta decay are reviewed. We propose two distinct models
where the baryon asymmetry is enhanced.Comment: 21 pages, RevTex. Revise
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