How to Argue about Health Care

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68919/2/10.1177_107755878704400102.pd

Computational code underlying the publication “Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting”

Spatial regulation of angiogenesis is important for the generation of functional engineered vasculature and the Notch ligands Jag1 and Dll4 are known to regulate endothelial sprouting. In this project, in vitro and in silico models were used to analyze the ability of micropatterned Jag1 and Dll4 to spatially control the sprouting process. Dll4 patterns, but not Jag1 patterns, were found to elicit spatial control and computational simulations suggest different timing of Notch activation by Jag1 and Dll4 to be the reason for their distinct effects. The more potent spatial control of sprouting by Dll4 in comparison to Jag1 could be exploited as a tool in vascular engineering and regenerative medicine

Fluorescence microscopy, image analysis and quantitative PCR data underlying the publication “Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting”

Spatial regulation of angiogenesis is important for the generation of functional engineered vasculature and the Notch ligands Jag1 and Dll4 are known to regulate endothelial sprouting. In this project, in vitro and in silico models were used to analyze the ability of micropatterned Jag1 and Dll4 to spatially control the sprouting process. Dll4 patterns, but not Jag1 patterns, were found to elicit spatial control and computational simulations suggest different timing of Notch activation by Jag1 and Dll4 to be the reason for their distinct effects. The more potent spatial control of sprouting by Dll4 in comparison to Jag1 could be exploited as a tool in vascular engineering and regenerative medicine. This dataset contains data from in vitro experiments on endothelial sprouting with human endothelial cells and micropatterned Jag1 and Dll4 ligands

Production of charged hadrons by positive muons on deuterium and xenon at 490 GeV

Results on the production of charged hadrons in muon-deuteron and muon-xenon interactions are presented. The data were taken with the E665 spectrometer, which was exposed to the 490 GeV muon beam of the Tevatron at Fermilab. The use of a streamer chamber as vertex detector provides nearly 4#pi# acceptance for charged particles. The #mu#D data are compared with the #mu#Xe data in terms of multiplicity distributions, average multiplicities, forward-backward multiplicity correlations, rapidity and transverse momentum distributions and of two-particle rapidity correlations of charged hadrons. The data cover a range of invariant hadronic masses W from 8 to 30 GeV. (orig.)Available from TIB Hannover: RR 2916(93-17) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Brain charts for the human lifespan

10.1038/s41586-022-04554-yNature6047906525-53