Synchronous Quadruple Lung Cancer Treated Curatively by Photodynamic Therapy

A 54-year-old male was diagnosed as having synchronous quadruple early stage lung cancer. All four tumors showed the same histologic type of in-situ or microinvasive squamous cell carcinoma, but existed independently in different bronchi. Photodynamic therapy of these four lesions was successfully performed by fiberoptic bronchoscopy because of the patient's poor pulmonary function. The patient is alive and well 51 months later

Nationwide patient registry for GNE myopathy in Japan

BACKGROUND: GNE myopathy is a slowly progressive autosomal recessive myopathy caused by mutations in the GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) gene. This study aimed to (1) develop a nationwide patient registry for GNE myopathy in order to facilitate the planning of clinical trials and recruitment of candidates, and (2) gain further insight into the disease for the purpose of improving therapy and care. METHODS: Medical records of genetically-confirmed patients with GNE myopathy at the National Center Hospital of the National Center of Neurology and Psychiatry (NCNP) were retrospectively reviewed in order to obtain data reflecting the severity and progression of the disease. We also referred to items in the datasheet of the nationwide registry of dystrophinopathy patients in the Registry of Muscular Dystrophies (Remudy). Items selected for the registration sheet included age, sex, age at onset, past history and complications, family history, body weight and height, pathological findings of muscle biopsy, grip power, walking ability, respiratory function, cardiac function, willingness to join upcoming clinical trials, and participation in patient associations. A copy of the original genetic analysis report was required of each patient. RESULTS: We successfully established the Remudy-GNE myopathy. Currently, 121 patients are registered nationwide, and 93 physicians from 73 hospitals collaborated to establish the registry. The mean age at onset was 27.7 ± 9.6 years, and 19.8% (24/121) of patients could walk without assistance. Mean presumed durations from onset to use of assistive devices (cane and/or braces) and a wheelchair, and loss of ambulation were 12.4, 15.2, and 21.1 years, respectively. Three patients had a past history and/or complication of idiopathic thrombocytopenia. To share the progress of this study with the community, newsletters were published on a regular basis, and included information regarding new phase I clinical trials for GNE myopathy. The newsletters also served as a medium to bring attention to the importance of respiratory evaluation and care for respiratory insufficiency. CONCLUSION: The Japanese Remudy-GNE myopathy is useful for clarifying the natural history of the disease and recruiting patients with genetically-confirmed GNE myopathy for clinical trials. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13023-014-0150-4) contains supplementary material, which is available to authorized users

Bulk motion-independent analyses of water diffusion changes in the brain during the cardiac cycle

金沢大学医薬保健研究域保健学系We evaluated dynamic changes in water diffusion in the brain during the cardiac cycle by using cine diffusion MRI. On a 1.5-T MRI, ECG-triggered single-shot diffusion echo planar imaging was used with sensitivity encoding, halfscan, and rectangular field of view techniques for minimizing bulk motion effects such as brain pulsation, with a data-sampling window of 3 ms. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in the white matter zone were determined in ten healthy volunteers and then compared with the intracranial volume change (ICVC) revealed by phase-contrast cine MRI during the cardiac cycle. In addition, a frequency analysis of these waveforms was performed. ADC and FA values changed significantly during the cardiac cycle, despite minimizing the effect of bulk motion, i.e., independent of bulk motion. The ADC was synchronized with the ICVC during the cardiac cycle. A significant positive correlation was noted among their amplitudes. Analysis of the dynamic change of water diffusion by use of cine diffusion MRI facilitates the assessment of intracranial conditions. © 2009 Japanese Society of Radiological Technology and Japan Society of Medical Physics

The influence of chondrules on sub-mm fragment shape distributions in Allende impact experiments

The surfaces of sub-kilometer-sized asteroids directly explored by spacecraft, such as Itokawa, Ryugu and Bennu, are covered with blocks and/or regolith particles, whose shapes are considered clues to understanding their formation and evolution on the asteroid's surface. Ryugu particles returned by the Hayabusa2 mission are likely fragments resulting from impacts because their shapes resemble impact fragments from laboratory experiments. However, there is a lack of laboratory impact experiments examining the shapes of fragments in carbonaceous chondrites, thought to originate from carbonaceous asteroids such as Ryugu and Bennu. The measured sizes of Ryugu particles are in the mm and sub-mm range, similar to the sizes of chondrules. Also, carbonaceous chondrites are generally structurally weaker than the basalts and granites often used in previous laboratory impact experiments. Differences in the strength of the chondrules and matrix might affect the overall strength of the meteorite. In this study, as a first step towards a better understanding of impact fragment shapes in carbonaceous chondrites, we conducted impact experiments on the carbonaceous meteorite Allende (CV3). A spherical alumina projectile with 1.0 mm and a glass projectile with 0.80 mm in diameter were fired into 1–2 cm-sized Allende targets at nominal impact velocities of 2.0 and 4.0 km/s, respectively. To investigate the correlation between the chondrules (typically sub-mm in size) and the shapes of fine fragments, we measured the shape distributions of sub-mm impact fragments using X-ray microtomography. We observed several impact fracture surfaces along the chondrule boundaries. In addition, these fragments tended to be rounder than fragments from previous impact experiments. However, because the total number of these fragments is relatively small, the fragments were found to have the same overall shape distribution as previous laboratory impact fragments, Itokawa particles and Ryugu particles. This may imply that impact fragment shapes are independent of the bulk material strength. These findings will be useful for understanding the formation process of regolith layers on asteroid surfaces, Itokawa particles, Ryugu particles, and Bennu particles.Validerad;2024;Nivå 2;2024-04-23 (signyg);Funder: JSPS KAKENHI (JP20K04048;JP22H00162;BR230501); SNSA (2021-00078);Full text license: CC BY</p