Meeting update: faecal microbiota transplantation––bench, bedside, courtroom?

A group of stakeholders met, under the aegis of the British Society of Gastroenterology, to discuss the current landscape of faecal microbiota transplant- ation (FMT) within the UK and beyond. The meeting covered a wide range of topics, ranging from the practical aspects of establishing an FMT service and regu- latory issues relating to its delivery, to research implications and likely future directions

Mixed population Minority Game with generalized strategies

We present a quantitative theory, based on crowd effects, for the market volatility in a Minority Game played by a mixed population. Below a critical concentration of generalized strategy players, we find that the volatility in the crowded regime remains above the random coin-toss value regardless of the "temperature" controlling strategy use. Our theory yields good agreement with numerical simulations.Comment: Revtex file + 3 figure

A microcontroller system for investigating the catch effect: Functional electrical stimulation of the common peroneal nerve

Correction of drop foot in hemiplegic gait is achieved by electrical stimulation of the common peroneal nerve with a series of pulses at a fixed frequency. However, during normal gait, the electromyographic signals from the tibialis anterior muscle indicate that muscle force is not constant but varies during the swing phase. The application of double pulses for the correction of drop foot may enhance the gait by generating greater torque at the ankle and thereby increase the efficiency of the stimulation with reduced fatigue. A flexible controller has been designed around the Odstock Drop Foot Stimulator to deliver different profiles of pulses implementing doublets and optimum series. A peripheral interface controller (PIC) microcontroller with some external circuits has been designed and tested to accommodate six profiles. Preliminary results of the measurements from a normal subject seated in a multi-moment chair (an isometric torque measurement device) indicate that profiles containing doublets and optimum spaced pulses look favourable for clinical use

Enhanced winnings in a mixed-ability population playing a minority game

We study a mixed population of adaptive agents with small and large memories, competing in a minority game. If the agents are sufficiently adaptive, we find that the average winnings per agent can exceed that obtainable in the corresponding pure populations. In contrast to the pure population, the average success rate of the large-memory agents can be greater than 50 percent. The present results are not reproduced if the agents are fed a random history, thereby demonstrating the importance of memory in this system.Comment: 9 pages Latex + 2 figure

Detecting Soil Macrofauna Using Ground-Penetrating Radar

Fossorial amphibians spend up to ten months belowground, but research into this critical habitat has been impeded by a lack of noninvasive detection methods. Ground-penetrating radar (GPR), however, offers a promising tool because amphibians have theoretically strong electromagnetic (EM) contrasts relative to the soil matrix, and thus potentially high detectability. The objectives of this study were to (1) evaluate GPR by (2) experimentally-inducing three soil thermal regimes that promote stratification in the burrowing depths of 15 Eastern American Toads (Anaxyrus americanus americanus) during the winter of 2011–2012 in Madison, WI, USA. We calculated reflectability and established the unique electronic signature of the toads in GPR datasets through measuring the water contents of the soil and toads as a proxy for the relative dielectric constant, an EM metric in GPR assessment. As toads emerged in the spring of 2012, we verified the GPR imagery with their emergence locations. The contrast in relative dielectric constants between the toads and the soil provided reflectance ratings that were 12–24 times greater than the detectable limit and confirmed that the toads were distinguishable from other soil features. The winter mortality of the toads, however, was 73%, which limited the replication with which GPR could be evaluated. We attribute the depth and rate of frost penetration from the treatments and weather of 2012 as the probable cause of mortality. Future research and conservation efforts may be facilitated with GPR by tracking temperate species belowground and linking behavior to environmental stressors

Ground-layer wavefront reconstruction from multiple natural guide stars

Observational tests of ground layer wavefront recovery have been made in open loop using a constellation of four natural guide stars at the 1.55 m Kuiper telescope in Arizona. Such tests explore the effectiveness of wide-field seeing improvement by correction of low-lying atmospheric turbulence with ground-layer adaptive optics (GLAO). The wavefronts from the four stars were measured simultaneously on a Shack-Hartmann wavefront sensor (WFS). The WFS placed a 5 x 5 array of square subapertures across the pupil of the telescope, allowing for wavefront reconstruction up to the fifth radial Zernike order. We find that the wavefront aberration in each star can be roughly halved by subtracting the average of the wavefronts from the other three stars. Wavefront correction on this basis leads to a reduction in width of the seeing-limited stellar image by up to a factor of 3, with image sharpening effective from the visible to near infrared wavelengths over a field of at least 2 arc minutes. We conclude that GLAO correction will be a valuable tool that can increase resolution and spectrographic throughput across a broad range of seeing-limited observations.Comment: 25 pages, 8 figures, to be published in Astrophys.

Analysis of Probabilistic Basic Parallel Processes

Basic Parallel Processes (BPPs) are a well-known subclass of Petri Nets. They are the simplest common model of concurrent programs that allows unbounded spawning of processes. In the probabilistic version of BPPs, every process generates other processes according to a probability distribution. We study the decidability and complexity of fundamental qualitative problems over probabilistic BPPs -- in particular reachability with probability 1 of different classes of target sets (e.g. upward-closed sets). Our results concern both the Markov-chain model, where processes are scheduled randomly, and the MDP model, where processes are picked by a scheduler.Comment: This is the technical report for a FoSSaCS'14 pape