24 research outputs found
Therapeutic antibody mediated depletion of activated dendritic cells and the prevention of graft versus host disease
Expression of the Chemokine Receptor CCR5 on Blood CD11C+ CD16+ Dendritic Cells Post-Allogeneic Hemopoietic Cell Transplant is Predictive for the Development of Acute Graft Versus Host Disease
319: CD300a and CD300c on Plasmacytoid Dendritic Cells are Down-Regulated by TLR7 and TLR9 Ligand Induced Type I Interferon
Prevention of graft versus host disease by antibody mediated depletion of activated dendritic cells
400: Resident Human Myeloid Dendritic Cell Activation and Local Allogeneic T Cell Responses in the Bone Marrow of Humanized NOD/SCID Mice
Haemophagocytic lymphohistiocytosis, interferon-gamma-naemia and Epstein-Barr virus involvement
MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells
The MUC1 mucin (CD227) is a cell surface mucin originally thought to be restricted to epithelial tissues. We report that CD227 is expressed on human blood dendritic cells (DC) and monocyte-derived DC following in vitro activation. Freshly isolated murine splenic DC had very low levels of CD227; however, all DC expressed CD227 following in vitro culture. In the mouse spleen, CD227 was seen on clusters within the red pulp and surrounding the marginal zone in the white pulp. Additionally, we confirm CD227 expression by activated human T cells and show for the first time that the CD227 cytoplasmic domain is tyrosine-phosphorylated in activated T cells and DC and is associated with other phosphoproteins, indicating a role in signaling. The function of CD227 on DC and T cells requires further elucidation