3,054 research outputs found
On the physical parametrization and magnetic analogs of the Emparan-Teo dihole solution
The Emparan-Teo non-extremal black dihole solution is reparametrized using
Komar quantities and the separation distance as arbitrary parameters. We show
how the potential can be calculated for the magnetic analogs of this
solution in the Einstein-Maxwell and Einstein-Maxwell-dilaton theories. We also
demonstrate that, similar to the extreme case, the external magnetic field can
remove the supporting strut in the non-extremal black dihole too.Comment: 9 pages, 1 figur
Male frequent attenders of general practice and their help seeking preferences
Background: Low rates of health service usage by men are commonly linked to masculine values and traditional male gender roles. However, not all men conform to these stereotypical notions of masculinity, with some men choosing to attend health services on a frequent basis, for a variety of different reasons. This study draws upon the accounts of male frequent attenders of the General Practitioner's (GP) surgery, examining their help-seeking preferences and their reasons for choosing services within general practice over other sources of support. Methods: The study extends thematic analysis of interview data from the Self Care in Primary Care study (SCinPC), a large scale multi-method evaluation study of a self care programme delivered to frequent attenders of general practice. Data were collected from 34 semi-structured interviews conducted with men prior to their exposure to the intervention. Results: The ages of interviewed men ranged from 16 to 72 years, and 91% of the sample (n= 31) stated that they had a current health condition. The thematic analysis exposed diverse perspectives within male help-seeking preferences and the decision-making behind men's choice of services. The study also draws attention to the large variation in men's knowledge of available health services, particularly alternatives to general practice. Furthermore, the data revealed some men's lack of confidence in existing alternatives to general practice. Conclusions: The study highlights the complex nature of male help-seeking preferences, and provides evidence that there should be no 'one size fits all' approach to male service provision. It also provides impetus for conducting further studies into this under researched area of interest. © 2011 WPMH GmbH
Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1
Chronic skin-healing defects are one of the leading challenges to lifelong well-being, affecting 2–5% of populations. Chronic wound formation is linked to age and diabetes and frequently leads to major limb amputation. Here we identify a strategy to reverse fibroblast senescence and improve healing rates. In healthy skin, fibronectin activates Rac1 in fibroblasts, causing migration into the wound bed, and driving wound contraction. We discover that mechanical stimulation of the skin with ultrasound can overturn healing defects by activating a calcium/CamKinaseII/Tiam1/Rac1 pathway that substitutes for fibronectin-dependent signaling and promotes fibroblast migration. Treatment of diabetic and aged mice recruits fibroblasts to the wound bed and reduces healing times by 30%, restoring healing rates to those observed in young, healthy animals. Ultrasound treatment is equally effective in rescuing the healing defects of animals lacking fibronectin receptors, and can be blocked by pharmacological inhibition of the CamKinaseII pathway. Finally, we discover that the migration defects of fibroblasts from human venous leg ulcer patients can be reversed by ultrasound, demonstrating that the approach is applicable to human chronic samples. By demonstrating that this alternative Rac1 pathway can substitute for that normally operating in the skin, we identify future opportunities for management of chronic wounds
Simulations of the Static Friction Due to Adsorbed Molecules
The static friction between crystalline surfaces separated by a molecularly
thin layer of adsorbed molecules is calculated using molecular dynamics
simulations. These molecules naturally lead to a finite static friction that is
consistent with macroscopic friction laws. Crystalline alignment, sliding
direction, and the number of adsorbed molecules are not controlled in most
experiments and are shown to have little effect on the friction. Temperature,
molecular geometry and interaction potentials can have larger effects on
friction. The observed trends in friction can be understood in terms of a
simple hard sphere model.Comment: 13 pages, 13 figure
The Importance of Time Congruity in the Organisation.
In 1991 Kaufman, Lane, and Lindquist proposed that time congruity in terms of an individual's time preferences and the time use methods of an organisation would lead to satisfactory performance and enhancement of quality of work and general life. The research reported here presents a study which uses commensurate person and job measures of time personality in an organisational setting to assess the effects of time congruity on one aspect of work life, job-related affective well-being. Results show that time personality and time congruity were found to have direct effects on well-being and the influence of time congruity was found to be mediated through time personality, thus contributing to the person–job (P–J) fit literature which suggests that direct effects are often more important than indirect effects. The study also provides some practical examples of ways to address some of the previously cited methodological issues in P–J fit research
Towards a formal description of the collapse approach to the inflationary origin of the seeds of cosmic structure
Inflation plays a central role in our current understanding of the universe.
According to the standard viewpoint, the homogeneous and isotropic mode of the
inflaton field drove an early phase of nearly exponential expansion of the
universe, while the quantum fluctuations (uncertainties) of the other modes
gave rise to the seeds of cosmic structure. However, if we accept that the
accelerated expansion led the universe into an essentially homogeneous and
isotropic space-time, with the state of all the matter fields in their vacuum
(except for the zero mode of the inflaton field), we can not escape the
conclusion that the state of the universe as a whole would remain always
homogeneous and isotropic. It was recently proposed in [A. Perez, H. Sahlmann
and D. Sudarsky, "On the quantum origin of the seeds of cosmic structure,"
Class. Quant. Grav. 23, 2317-2354 (2006)] that a collapse (representing physics
beyond the established paradigm, and presumably associated with a
quantum-gravity effect a la Penrose) of the state function of the inflaton
field might be the missing element, and thus would be responsible for the
emergence of the primordial inhomogeneities. Here we will discuss a formalism
that relies strongly on quantum field theory on curved space-times, and within
which we can implement a detailed description of such a process. The picture
that emerges clarifies many aspects of the problem, and is conceptually quite
transparent. Nonetheless, we will find that the results lead us to argue that
the resulting picture is not fully compatible with a purely geometric
description of space-time.Comment: 53 pages, no figures. Revision to match the published versio
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