Managerial Editor’s Introduction: Critical Disability Discourse/Discours Critiques dans le Champ du Handicap, Volume 5

Editorial Board and Reviewers, Introduction, Overview, Acknowledgement

New Generation: Building a clean European electricity system by 2035

This study explores the least-cost pathways to a clean power system in Europe, compatible with the Paris Agreement climate goals (1.5C). Detailed, country-by-country, hour-by-hour power system modelling confirms the feasibility of almost completely decarbonising Europe's power sector by 2035, while expanding the electricity supply. Key metrics are quantified in order to benchmark progress, while accounting for a range of uncertainties. Crucially, the costs of competing routes are assessed, including the costs of developing the power system according to current plans. This report summarises the results of three modelled pathways for the European power sector. The Stated Policy pathway is aligned with stated national policies until 2035. The other two pathways -- Technology Driven and System Change -- are computed to minimise cost while remaining within a carbon budget compatible with the Paris Agreement climate goals. The latter two pathways expand clean electrification, but differ in their assumptions about available technologies and the levels of energy savings resulting from societal change

Interaction between contours and eye movements in the perception of afterimages: A test of the signal ambiguity theory

An intriguing property of afterimages is that conscious experience can be strong, weak, or absent following identical stimulus adaptation. Previously we suggested that postadaptation retinal signals are inherently ambiguous, and therefore the perception they evoke is strongly influenced by cues that increase or decrease the likelihood that they represent real objects (the signal ambiguity theory). Here we provide a more definitive test of this theory using two cues previously found to influence afterimage perception in opposite ways and plausibly at separate loci of action. However, by manipulating both cues simultaneously, we found that their effects interacted, consistent with the idea that they affect the same process of object interpretation rather than being independent influences. These findings bring contextual influences on afterimages into more general theories of cue combination, and we suggest that afterimage perception should be considered alongside other areas of vision science where cues are found to interact in their influence on perception

TF-CBT Training Augmented with a Self-Care Focus: Understanding Facilitators and Barriers to Treatment Implementation.

Clinicians working with youth exposed to trauma may be at increased risk for experiencing elevated levels of stress and symptoms of secondary traumatic stress, which can negatively impact clinician wellbeing and ultimately contribute to reduced access to quality care for clients. An innovative Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) training incorporating self-care practices (i.e., Practice What You Preach; PWYP) was developed to help facilitate the implementation of TF-CBT and to enhance clinicians\u27 coping and decrease stress. The primary purpose of this study was to determine whether the PWYP-augmented training met three Objectives: (1) increase clinicians\u27 feelings of TF-CBT competency; (2) improve clinicians\u27 coping abilities/reduce clinicians\u27 stress; and (3) increase clinicians\u27 insight into the benefits and/or challenges clients may experience in treatment. An exploratory aim was also developed to identify additional facilitators and barriers of TF-CBT implementation. The written reflections of 86 community-based clinicians who participated in the PWYP-augmented TF-CBT training were examined using qualitative methods. The majority of clinicians indicated increased feelings of competency and improved coping abilities and/or stress levels; almost half mentioned increased insight into clients\u27 experiences. The most frequently mentioned additional facilitators were related to elements of the TF-CBT treatment model. Anxiety/self-doubt was the barrier most frequently mentioned, though all clinicians who mentioned this barrier indicated it lessened or resolved over the course of the training. Incorporating self-care strategies into trainings may serve as a facilitator for TF-CBT implementation by enhancing the competency and well-being of clinicians. The additional insights into barriers and facilitators can be used to further improve the PWYP initiative and future training and implementation efforts

Miniaturization of Chemical Analysis Systems – A Look into Next Century's Technology or Just a Fashionable Craze?

Miniaturization of already existing techniques in on-line analytical chemistry is an alternative to compound-selective chemical sensors. Theory points in the direction of higher efficiency, faster analysis time, and lower reagent consumption. Micromachining, a well known photolithographic technique for structures in the micrometer range, is introduced and documented with structures as examples for flow injection analysis, electrophoresis, and a detector cell

Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress

When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated. This condition can lead to the initiation and/or to the progression of atherosclerosis, tumors or pulmonary hypertension; diseases that are decisively furthered by the presence of oxidizing agents. Redox sensitive genes, like the zinc finger transcription factor early growth response 1 (Egr-1), play a pivotal role in the pathophysiology of these diseases. Apart from inducing apoptosis, signaling partners like the MEK/ERK pathway or the protein kinase C (PKC) can activate salvage programs such as cell proliferation that do not ameliorate, but rather worsen their outcome. Here, we review the currently available data on Egr-1 related signal transduction cascades in response to oxidative stress in the progression of epidemiologically significant diseases. Knowing the molecular pathways behind the pathology will greatly enhance our ability to identify possible targets for the development of new therapeutic strategies

Delivering safe, effective nutrition and hydration care to residents with dysphagia: a theory-based approach to developing a link dysphagia practitioner

This report is independent research funded by the National Institute for Health Research (Research for Patient Benefit programme, NIHR200091). The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. No Abstract available

Delivering safe, effective nutrition and hydration care to residents with dysphagia: a theory-based approach to developing a link dysphagia practitioner

This report is independent research funded by the National Institute for Health Research (Research for Patient Benefit programme, NIHR200091). The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. No Abstract available