Report on the State of Available Data for the Study of International Trade and Foreign Direct Investment

This report, prepared for the Committee on Economic Statistics of the American Economic Association, examines the state of available data for the study of international trade and foreign direct investment. Data on values of imports and exports of goods are of high quality and coverage, but price data suffer from insufficient detail. It would be desirable to have more data measuring value-added in trade as well as prices of comparable domestic and imported inputs. Value data for imports and exports of services are too aggregated and valuations are questionable, while price data for service exports and imports are almost non-existent. Foreign direct investment data are of high quality but quality has suffered from budget cuts. Data on trade in intellectual property are fragmentary. The intangibility of the trade makes measurement difficult, but budget cuts have added to the difficulties. Modest funding increases would result in data more useful for research and policy analysis.

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag, pol, and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC., compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HTV-1 infection

Thirty Years After Michael E. Porter: What Do We Know About Business Exit?

Although a business exit is an important corporate change initiative, the buyer’s side seems to be more appealing to management researchers than the seller’s because acquisitions imply growth, i.e., success. Yet from an optimistic viewpoint, business exit can effectively create value for the selling company. In this paper we attempt to bring the relevance of the seller’s side back into our consciousness by asking: What do we know about business exit? We start our exploration with Porter (1976), focusing on literature that investigates the antecedents of, barriers to, and outcomes of business exit. We also include studies from related fields such as finance and economics.1 Through this research we determine three clusters of findings: factors promoting business exit, exit barriers, and exit outcomes. Overall, it is the intention of this paper to highlight the importance of business exit for research and practice. Knowing what we know about business exits and their high financial value we should bear in mind that exit need not mean failure but a new beginning for a corporation

Trends in the GloFAS-ERA5 river discharge reanalysis

The main objective of this study is to analyse the GloFAS-ERA5 river discharge reanalysis for any noticeable change (including gradual trends or discontinuities) in the annual mean time series across the 1979-2018 (40-year) period, and to evaluate how realistic these are compared with available observed river discharge time series. These variabilities are quantified by linear regression in order to highlight any concerning features in the GloFAS-ERA5 time series. This work is particularly important for GloFAS, as large trends, discontinuities or other similar features could have a major consequence on the GloFAS flood thresholds in around 50% of catchments, which are based on GloFAS-ERA5, and thus subsequently on the issuing of flood warnings. In addition, this study also contributes to the understanding of the water cycle variable behaviour in ERA5 (driver of GloFAS-ERA5) and ERA5-Land (higher resolution land reanalysis forced by ERA5, produced offline) by exploring the linear trends in river discharge and related hydrological variables. In exploring the stability of the time series in ERA5, we seek to trigger potential further discussions and research studies, which subsequently should help with the planning and development for the next generation ECMWF reanalysis, ERA6