15 research outputs found
The Iowa Homemaker vol.3, no.4-5
Table of Contents
We “Do Over” Our Rooms by Irma Camp and Alice Dodge, page 1
The Mysteries of Amateur Make Up by Frederica Shattuck, page 2
Fall Time Is Pickling Time by Katherine Howells, page 4
Episodes Concerning Evolution of Home Economics by Ruth Elaine Wilson, page 5
Tea – Suggestive of the Rainbow by Esther Ellen Rayburn, page 6
Vary the Vegetable by Blanche Ingersoll, page 7
Constipation and Its Dangers by Anne Mundt, page 8
Graduate Credit Conference for Vocational Home Economics at Iowa State by Eleanor Murray, page 9
Fish That Is Appetizing by Maxine Smith, page 9
Economy, Or a Wrong Idea by Harriett Wallace, page 1
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Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
AbstractMany individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower coronary artery disease (CAD) risk but higher venous thromboembolism (VTE) risk. We identify PROCR-p.Ser219Gly as the likely causal variant at the locus and protein C as a causal factor. Using genetic analyses, human recall-by-genotype and in vitro experimentation, we demonstrate that PROCR-219Gly increases plasma levels of (activated) protein C through endothelial protein C receptor (EPCR) ectodomain shedding in endothelial cells, attenuating leukocyte–endothelial cell adhesion and vascular inflammation. We also associate PROCR-219Gly with an increased pro-thrombotic state via coagulation factor VII, a ligand of EPCR. Our study, which links PROCR-219Gly to CAD through anti-inflammatory mechanisms and to VTE through pro-thrombotic mechanisms, provides a framework to reveal the mechanisms underlying similar cross-phenotype associations.</jats:p
The Iowa Homemaker vol.3, no.4-5
Table of Contents
We “Do Over” Our Rooms by Irma Camp and Alice Dodge, page 1
The Mysteries of Amateur Make Up by Frederica Shattuck, page 2
Fall Time Is Pickling Time by Katherine Howells, page 4
Episodes Concerning Evolution of Home Economics by Ruth Elaine Wilson, page 5
Tea – Suggestive of the Rainbow by Esther Ellen Rayburn, page 6
Vary the Vegetable by Blanche Ingersoll, page 7
Constipation and Its Dangers by Anne Mundt, page 8
Graduate Credit Conference for Vocational Home Economics at Iowa State by Eleanor Murray, page 9
Fish That Is Appetizing by Maxine Smith, page 9
Economy, Or a Wrong Idea by Harriett Wallace, page 10</p