Submersion

The artist discusses the influence, concept, and process behind creating a cohesive body of work and accompanying show, Submersion, for the completion of her Bachelor of Arts degree and undergraduate research for the Fine and Performing Art Scholars branch of East Tennessee State University\u27s Honors College. The show is to be held May 1st through May 7th of 2014 with its reception on May 3rd in the Submarine Gallery located on ETSU campus. The artist explored themes of the unknown, subconscious, and memory, using water as a reoccurring symbol. The works include five large portraits and two small to medium underwater landscapes in oil paint completed between Fall of 2012 and Spring of 2014. Three large-scale charcoal drawings completed in the Spring of 2013 relate to this body of work as part of a further exploration of the concepts of interest, but will not be included in the Submarine Gallery show and were instead presented as part of the B.A. Senior show in the Fall of 2013. Influences on the artist\u27s work come from artists Jeremy Miranda, Alyssa Monks, Bill Viola, Susanna Majuri, Andreas Franke, and the work and techniques of the Old Master

The Effect of Professionally-Facilitated Group Support on Psychological Well-Being among Clients with Cancer

Many persons suffer from cancer, some of whom seek psychological relief through group support. Despite the widely held belief that group support helps, its efficacy has not been consistently evident in the scientific literature. The purpose of this study was to compare the effect of professionally-facilitated group support on the psychological well-being of clients with cancer between persons who participated in professionally-facilitated group support with those who did not. A comparison design measured effect by the Psychological General Well-Being (PGWB) index. Each study enrollee was diagnosed with a new or recurrent cancer within 18 months of study entry. ANCOVA was used to consider the effects of stage of disease, age and pretest. Participants were briefly interviewed three times during the study period to monitor attendance, to record participation in complementary therapies and to capture intervening events, which could affect results. Study findings were not significant measured by the PGWB (F [4,47] = .097, p = .757, p ≤.05). Age was inadequately associated (r = .061, p = ≤.05) with the dependent variable and stage of disease and pretest were only weakly correlated (r = .362, p = ≤.05 and r = .423, p = ≤.05). A disproportionate number of study participants did not attend group support (n = 43) versus those who did (n = 9). Of those who did, only three fulfilled the threshold for attendance. Recruitment sites may have been a factor in the study\u27s enrollee composition for the two groups used for comparison. Other findings indicated that while select individuals increased their PGWB score after group support attendance, many others who did not attend group support had no change or improved scores. Individuals may vary in their psychological morbidity over time. Further research is indicated: (1) replication of the study with equal sample sizes may yield different results; (2) adding psychological morbidity as a comprehensive screening indicator in the design of studies may define the target population; and (3) group support studies should explore the psychological distress perceived by persons with cancer concurrent with the timing of diagnosis and treatment. Findings may focus attention on what may be unique about group support in a population with cancer and propel future studies

Long discontinuous carbon fibre/polypropylene composites for high volume structural applications

A processing route is presented to manufacture discontinuous carbon fibre reinforced polypropylene (CF.PP) composites, using much longer fibre lengths (25mm) and higher volume fractions (up to 45%) than previously reported in the literature. Carbon fibre tows are coated with different ratios of polypropylene, blended with a maleic anhydride coupling agent, to investigate the influence of the interfacial shear strength at the microscale on the macroscale composite properties. Improvements in the tensile performance at the macroscale (70% increase) are not as high as those reported for the interfacial shear strength at the microscale (300%), following the addition of the coupling agent. Consequently, the tensile strength of the CF.PP material is only 45% of values reported for carbon fibre/epoxy systems, however, the tensile stiffness is comparable. This demonstrates the potential for using CF.PP for structural applications, following further process optimisation to overcome the current high levels of porosity (3.3% at 0.45Vf) to improve the tensile strength

The Pre-entry Program at UTMSH: Effect on Academic Performance of First-Year Medical Students

Introduction: The Pre-Entry Program at The University of Texas Medical School at Houston is presented to assist entering students who are judged to be at risk for academic difficulty. It requires a significant commitment of time on the part of faculty, staff and students. The effectiveness of this program needs to be evaluated. [See PDF for complete abstract

Does modafinil enhance activity of patients with myotonic dystrophy?: A double-blind placebo-controlled crossover study

We performed a double-blind placebo-controlled crossover study in 13 patients with myotonic dystrophy to address the question whether modafinil, known to improve hypersomnolence in myotonic dystrophy, may improve levels of activity as well. We used the Epworth Sleepiness Scale as a measure of hypersomnolence and a structured interview of the patient and the partner or housemate as a measure of activity. We additionally used a restricted form of the RAND-36 to relate a possible improvement of activity to perceived general health. We confirmed earlier positive findings of modafinil regarding reduced somnolence (p = 0.015), but no significant effects were seen regarding activity levels (p = 0.2 for patients’ self-reports and 0.5 for partners’ reports)

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion

Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles

Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric aggregates

The presence of oligomeric aggregates, which is often observed during the process of amyloid formation, has recently attracted much attention since it has been associated with neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. We provide a description of a sequence-indepedent mechanism by which polypeptide chains aggregate by forming metastable oligomeric intermediate states prior to converting into fibrillar structures. Our results illustrate how the formation of ordered arrays of hydrogen bonds drives the formation of beta-sheets within the disordered oligomeric aggregates that form early under the effect of hydrophobic forces. Initially individual beta-sheets form with random orientations, which subsequently tend to align into protofilaments as their lengths increases. Our results suggest that amyloid aggregation represents an example of the Ostwald step rule of first order phase transitions by showing that ordered cross-beta structures emerge preferentially from disordered compact dynamical intermediate assemblies.Comment: 14 pages, 4 figure

Social, environmental and psychological factors associated with objective physical activity levels in the over 65s

Objective: To assess physical activity levels objectively using accelerometers in community dwelling over 65 s and to examine associations with health, social, environmental and psychological factors. Design: Cross sectional survey. Setting: 17 general practices in Scotland, United Kingdom. Participants: Random sampling of over 65 s registered with the practices in four strata young-old (65–80 years), old-old (over 80 years), more affluent and less affluent groups. Main Outcome Measures: Accelerometry counts of activity per day. Associations between activity and Theory of Planned Behaviour variables, the physical environment, health, wellbeing and demographic variables were examined with multiple regression analysis and multilevel modelling. Results: 547 older people (mean (SD) age 79(8) years, 54% female) were analysed representing 94% of those surveyed. Accelerometry counts were highest in the affluent younger group, followed by the deprived younger group, with lowest levels in the deprived over 80 s group. Multiple regression analysis showed that lower age, higher perceived behavioural control, the physical function subscale of SF-36, and having someone nearby to turn to were all independently associated with higher physical activity levels (R2 = 0.32). In addition, hours of sunshine were independently significantly associated with greater physical activity in a multilevel model. Conclusions: Other than age and hours of sunlight, the variables identified are modifiable, and provide a strong basis for the future development of novel multidimensional interventions aimed at increasing activity participation in later life.Publisher PDFPeer reviewe