250 research outputs found
Mechanized Percussion Well Drilling
The Mechanized Percussion Well Drilling Project seeks to design a simple mechanized well drilling system to be used for drilling shallow water wells in Burkina Faso, Africa. These systems will be operated by local drilling teams, allowing them to earn an income for themselves and their families. Currently our end users, the Burkinabe Well Drilling Team, have trouble drilling through hard rock layers, and often must abandon holes due to inadequate equipment. The goal of this project is to enable the drillers to efficiently drill through these rock layers with a mechanized percussion rig and supporting drilling equipment.
One of the areas the project has focused on this year was testing our new steel cathead, a critical piece of the drilling rig which severely wore during in-country testing in the summer of 2017. After 40 hours of testing with no visible wear, we were confident that our new cathead would be sufficient. We also designed a new, heavier drill bit that was more able to concentrate the force of each impact. Finally, we tested our system using ropes that can be bought in Burkina Faso to ensure our system will be sustainable for our end users.https://mosaic.messiah.edu/engr2020/1003/thumbnail.jp
An Effective Model for Crumpling in Two Dimensions?
We investigate the crumpling transition for a dynamically triangulated random
surface embedded in two dimensions using an effective model in which the
disordering effect of the variables on the correlations of the normals is
replaced by a long-range ``antiferromagnetic'' term. We compare the results
from a Monte Carlo simulation with those obtained for the standard action which
retains the 's and discuss the nature of the phase transition.Comment: 5 page
First-order transition of tethered membranes in 3d space
We study a model of phantom tethered membranes, embedded in three-dimensional
space, by extensive Monte Carlo simulations. The membranes have hexagonal
lattice structure where each monomer is interacting with six nearest-neighbors
(NN). Tethering interaction between NN, as well as curvature penalty between NN
triangles are taken into account. This model is new in the sense that NN
interactions are taken into account by a truncated Lennard-Jones potential
including both repulsive and attractive parts. The main result of our study is
that the system undergoes a first-order crumpling transition from low
temperature flat phase to high temperature crumpled phase, in contrast with
early numerical results on models of tethered membranes.Comment: 5 pages, 6 figure
Smooth Random Surfaces from Tight Immersions?
We investigate actions for dynamically triangulated random surfaces that
consist of a gaussian or area term plus the {\it modulus} of the gaussian
curvature and compare their behavior with both gaussian plus extrinsic
curvature and ``Steiner'' actions.Comment: 7 page
Folding transitions of the triangular lattice with defects
A recently introduced model describing the folding of the triangular lattice
is generalized allowing for defects in the lattice and written as an Ising
model with nearest-neighbor and plaquette interactions on the honeycomb
lattice. Its phase diagram is determined in the hexagon approximation of the
cluster variation method and the crossover from the pure Ising to the pure
folding model is investigated, obtaining a quite rich structure with several
multicritical points. Our results are in very good agreement with the available
exact ones and extend a previous transfer matrix study.Comment: 16 pages, latex, 5 postscript figure
Folding of the Triangular Lattice with Quenched Random Bending Rigidity
We study the problem of folding of the regular triangular lattice in the
presence of a quenched random bending rigidity + or - K and a magnetic field h
(conjugate to the local normal vectors to the triangles). The randomness in the
bending energy can be understood as arising from a prior marking of the lattice
with quenched creases on which folds are favored. We consider three types of
quenched randomness: (1) a ``physical'' randomness where the creases arise from
some prior random folding; (2) a Mattis-like randomness where creases are
domain walls of some quenched spin system; (3) an Edwards-Anderson-like
randomness where the bending energy is + or - K at random independently on each
bond. The corresponding (K,h) phase diagrams are determined in the hexagon
approximation of the cluster variation method. Depending on the type of
randomness, the system shows essentially different behaviors.Comment: uses harvmac (l), epsf, 17 figs included, uuencoded, tar compresse
Altered H19/miR‐675 expression in skeletal muscle is associated with low muscle mass in community‐dwelling older adults
Background:
Despite increasing knowledge of the pathogenesis of muscle ageing, the molecular mechanisms are poorly understood. Based on an expression analysis of muscle biopsies from older Caucasian men, we undertook an in-depth analysis of the expression of the long non-coding RNA, H19, to identify molecular mechanisms that may contribute to the loss of muscle mass with age.
Methods:
We carried out transcriptome analysis of vastus lateralis muscle biopsies from 40 healthy Caucasian men aged 68–76 years from the Hertfordshire Sarcopenia Study (HSS) with respect to appendicular lean mass adjusted for height (ALMi). Validation and replication was carried out using qRT-PCR in 130 independent male and female participants aged 73–83 years recruited into an extension of the HSS (HSSe). DNA methylation was assessed using pyrosequencing.
Results:
Lower ALMi was associated with higher muscle H19 expression (r2 = 0.177, P < 0.001). The microRNAs, miR-675-5p/3p encoded by exon 1 of H19, were positively correlated with H19 expression (Pearson r = 0.192 and 0.182, respectively, P < 0.03), and miR-675-5p expression negatively associated with ALMi (r2 = 0.629, P = 0.005). The methylation of CpGs within the H19 imprinting control region (ICR) were negatively correlated with H19 expression (Pearson r = −0.211 to −0.245, P ≤ 0.05). Moreover, RNA and protein levels of SMAD1 and 5, targets of miR-675-3p, were negatively associated with miR-675-3p (r2 = 0.792 and 0.760, respectively) and miR-675-5p (r2 = 0.584 and 0.723, respectively) expression, and SMAD1 and 5 RNA levels positively associated with greater type II fibre size (r2 = 0.184 and 0.246, respectively, P < 0.05).
Conclusions:
Increased expression profiles of H19/miR-675-5p/3p and lower expression of the anabolic SMAD1/5 effectors of bone morphogenetic protein (BMP) signalling are associated with low muscle mass in older individuals
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