Integrated polymers (PVCi/PMATRIFE) microring resonators for low power tunable filters

International audienceIn this paper we present optical and thermo-optical characterization results of integrated filters based on micro-ring resonators fabricated with a couple of polymers ''PVCI/PMATRIFE''. Their high index contrast (Dn 0.15 at the wavelength of 1550 nm) allows to make small size waveguides with cross sections of 1.5 1.5 mm2. The study of the impact of different gaps on the extinction ratio and FWHM (full width at half maximum) of filters leads to a better design. First experiments of thermal tunability of the microring filter using a thermo-electric cooler (TEC) are also reported giving a 5 nm shift of the dropped wavelength for a temperature change of 40 K. The fabrication of gold electrodes on microrings is reported and the electrical power required for the tuning of the drop wavelength of 0.0055 nm/1 mW show that with an optimized electrode design the consumption will be low

Les poissons de la Grande Grotte d'Arcy-sur-Cure (Yonne)

Un original método de investigacion, mediante adelgazamiento de la calcita, utilizado por primera vez en una cueva con decoración paleolítica ha permitido sacar a la luz, entre otras cosas, cuatro peces pintados en negro sobre las paredes de la Grande Grotte d'Arcy-sur-Cure (Yonne, France). Dichos peces, salmónidos y lucio, confirman el carácter excepcional el bestiario de esta gruta constituido por animales que no están presentes en las demás, a excepción de la de la cueva Chauvet (Ardechè) ; mamuts, rinocerontes, osos, felino, aves, megáceros. Los vestigios, bien conservados, encontrados sobre su suelo nos han permitido determinar que fue utilizada en la época auriñaciense gravetiense

Cyclotomy and Ramanujan sums in quantum phase locking

Phase-locking governs the phase noise in classical clocks through effects described in precise mathematical terms. We seek here a quantum counterpart of these effects by working in a finite Hilbert space. We use a coprimality condition to define phase-locked quantum states and the corresponding Pegg-Barnett type phase operator. Cyclotomic symmetries in matrix elements are revealed and related to Ramanujan sums in the theory of prime numbers. The employed mathematical procedures also emphasize the isomorphism between algebraic number theory and the theory of quantum entanglementComment: 6 pages, 3 figures, version accepted at Phys. Lett.

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

We have examined the regulatory role of the individual components of the immunoglobulin antigen receptor in B-cell development by transgenic complementation of Rag-1 deficient (Rag-1⁻) mice. Complementation with a membrane µ heavy chain (µHC) gene allows progression of developmentally arrested Rag-1⁻ pro-B-cells to the small pre-B cell stage, whereas the introduction of independently integrated µHC and κ light chain (κLC) transgenes promotes the appearance of peripheral lymphocytes which, however, remain unresponsive to external stimuli. Complete reconstitution of the B-cell lineage and the emergence of functionally nature Rag-1⁻ peripheral B cells is achieved by the introduction of cointegrated heavy and light chain transgenes encoding an anti-H-2^k antibody. This experimental system demonstrates the competence of the µHC and κLC to direct and regulate the sequential stages of B-cell differentiation, defines the time at which negative selection of self-reactive B cells occurs, and shows that elimination of these cells occurs equally well in the absence of Rag-1 as in its presence. These data also support the hypothesis that Rag-1 directly participates in the V(D)J recombination process

Validation of a chemiluminescent assay for specific SARS-CoV-2 antibody

Faced with the COVID-19 pandemic and its impact on the availability and quality of both therapeutic and diagnostic methods, the Belgian authorities have decided to launch a procedure for additional evaluation of the performance of serological tests offered for sale on the national territory. This has been proposed with a double aim: (1) an in-depth verification of the analytical and clinical performances presented by the manufacturer and (2) an economy of scale in terms of centralized validation for all the laboratories using the tests subject to evaluation. A retrospective validation study was conducted including the serum of 125 patients in order to determine the analytical and clinical performances of the LIAISON®SARS-CoV-2 from DiaSorin® detecting anti-SARS-CoV-2 IgG and to compare its clinical performance with the enzyme-linked immunosorbent assay (ELISA) test from Euroimmun®, one of the first commercially available tests allowing the detection of anti-SARS-CoV-2 IgA and IgG. The performances of the LIAISON®SARS-CoV-2 satisfied all the acceptance criteria and provided "real world" analytical and clinical performances very close to the ones reported by the manufacturer in its insert kit. Comparison between the LIAISON®SARS-CoV-2 and the ELISA method did not reveal any difference between the two techniques in terms of sensitivities and specificities regarding the determination of the IgG. This study reports the validation of the LIAISON®SARS-CoV-2 allowing to detect IgG antibodies specifically directed against SARS-CoV-2. The analytical and clinical performances are excellent, and the automation of the test offers important rates, ideal for absorbing an extension of testing.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Clinical performance of the Elecsys electrochemiluminescent immunoassay for the detection of SARS-CoV-2 total antibodies

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Impact of drainage on soil-forming mechanisms in a French Albeluvisol: Input of mineralogical data in mass-balance modelling

International audienceResearch on soil pedogenesis has mainly focused on the long-term soil formation and has most often neglected recent soil evolutions in response to human practices. Such recent soil evolutions are however of considerable interest to study the timing of soil forming processes in response to changes in environmental conditions. In this paper, we model the Albeluvisol evolution in response to agricultural drainage. This was considered as a model case to study the velocity of mineralogical changes in soil as a result of eluviation and redox processes. We used a space-for-time substitution approach in combination with mass balance modelling based on mineralogical data in order to identify and characterise the mineralogical transformations responsible for the recent soil evolution in response to subsurface drainage. This approach allowed demonstrating that the main effects of subsurface drainage are (i) increasing precipitation of Mn oxides and Mn-rich ferrihydrite with decreasing distance to the drain as a result of the change in redox conditions and (ii) increasing loss of clay-sized oxides and smectites due to the enhanced eluviation in the vicinity of the drain. Both processes induce significant matter fluxes in comparison with those that occurred over the long-term soil formation. Nowadays, the precipitation of Mn oxides and Mn-rich ferrihydrite seems to still be active in the studied soil. On the opposite, the eluviation process appears less active than immediately after the drainage network installation, if not totally inactive. It thus demonstrates that some soil processes may have significant impact on the soil mineralogical composition even if they are only active over very short periods of time after a change in environmental conditions

Mouse model phenotypes provide information about human drug targets

Motivation: Methods for computational drug target identification use information from diverse information sources to predict or prioritize drug targets for known drugs. One set of resources that has been relatively neglected for drug repurposing is animal model phenotype. Results: We investigate the use of mouse model phenotypes for drug target identification. To achieve this goal, we first integrate mouse model phenotypes and drug effects, and then systematically compare the phenotypic similarity between mouse models and drug effect profiles. We find a high similarity between phenotypes resulting from loss-of-function mutations and drug effects resulting from the inhibition of a protein through a drug action, and demonstrate how this approach can be used to suggest candidate drug targets. Availability and implementation: Analysis code and supplementary data files are available on the project Web site at https://drugeffects.googlecode.com. Contact: [email protected] or [email protected] Supplementary information: Supplementary data are available at Bioinformatics online

Zinc Redistribution in a Soil Developed from Limestone During Pedogenesis

International audienceThe long-term redistribution of Zn in a naturally Zn-enriched soil during pedogenesis was quantified based on mass balance calculations. According to their fate, parent limestones comprised three Zn pools: bound to calcite and pyritesphalerite grains, bound to phyllosilicates and bound to goethite in the inherited phosphate nodules. Four pedological processes, i.e., carbonate dissolution, two stages of redox processes and eluviation, redistributed Zn during pedogenesis. The carbonate dissolution of limestones released Zn bound to calcite into soil solution. Due to residual enrichment, Zn concentrations in the soil are higher than those in parent limestones. Birnessite, ferrihydrite and goethite dispersed in soil horizon trapped high quantities of Zn during their formation. Afterwards, primary redox conditions induced the release of Zn and Fe into soil solution, and the subsequent individualization of Fe and Mn into Zn-rich concretions. Both processes and subsequent aging of the concretions formed induced significant exportation of Zn through the bottom water table. Secondary redox conditions promoted the weathering of Fe and Mn oxides in cements and concretions. This process caused other losses of Zn through lateral exportation in an upper water table. Concomitantly, eluviation occurred at the top of the solum. The lateral exportation of eluviated minerals through the upper water table limited illuviation. Eluviation was also responsible for Zn loss, but this Zn bound to phyllosilicates was not bioavailabl