Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 Infection

The distribution of secretory leukocyte protease inhibitor (SLPI) at entry portals indicates its involvement in defending the host from pathogens, consistent with the ability of SLPI to inhibit human immunodeficiency virus (HIV)-1 infection by an unknown mechanism. We now demonstrate that SLPI binds to the membrane of human macrophages through the phospholipid-binding protein, annexin II. Based on the recent identification of human cell membrane phosphatidylserine (PS) in the outer coat of HIV-1, we define a novel role for annexin II, a PS-binding moiety, as a cellular cofactor supporting macrophage HIV-1 infection. Moreover, this HIV-1 PS interaction with annexin II can be disrupted by SLPI or other annexin II–specific inhibitors. The PS–annexin II connection may represent a new target to prevent HIV-1 infection

Braking System for a Longboard

The goal of this project was to design, manufacture and test a braking system for longboards that allows for controlled deceleration of the board and the rider. Currently longboards do not come with a system for controlling speed or stopping, and alternative methods for braking on a longboard are difficult and can result in injury. Our system allows the rider to use a pedal to transfer stepping force to a friction interface with the ground. The design process was guided by the principals of axiomatic design. The prototype was manufactured using CNC machines, rapid prototyping and urethane casting. Tests were performed for functionality, ride-ability and braking performance

EduVentures WebExpedition

This project, sponsored by EduVentures and the National Museum of Namibia, sought to increase Namibian secondary students' awareness of biodiversity by creating and deploying a computer game called WebExpedition. We received input from teachers and students to optimize the game's usefulness and effectiveness, and performed trial runs with Namibian students. The game teaches students about scientific classification of organisms, and allows students to connect animals and plants to their habitats in Namibia