223 research outputs found
Giant Rashba splitting of quasi-1D surface states on Bi/InAs(110)-(21)
Electronic states on the Bi/InAs(110)-(21) surface and its
spin-polarized structure are revealed by angle-resolved photoelectron
spectroscopy (ARPES), spin-resolved ARPES, and density-functional-theory
calculation. The surface state showed quasi-one-dimensional (Q1D) dispersion
and a nearly metallic character; the top of the hole-like surface band is just
below the Fermi level. The size of the Rashba parameter ()
reached quite a large value (5.5 eV\AA). The present result would provide
a fertile playground for further studies of the exotic electronic phenomena in
1D or Q1D systems with the spin-split electronic states as well as for advanced
spintronic devices.Comment: 8 pages (double column), 7 figures and 1 tabl
Atomic correlations in itinerant ferromagnets: quasi-particle bands of nickel
We measure the band structure of nickel along various high-symmetry lines of
the bulk Brillouin zone with angle-resolved photoelectron spectroscopy. The
Gutzwiller theory for a nine-band Hubbard model whose tight-binding parameters
are obtained from non-magnetic density-functional theory resolves most of the
long-standing discrepancies between experiment and theory on nickel. Thereby we
support the view of itinerant ferromagnetism as induced by atomic correlations.Comment: 4 page REVTeX 4.0, one figure, one tabl
Thermodynamic evidence for field-angle dependent Majorana gap in a Kitaev spin liquid
The exactly-solvable Kitaev model of two-dimensional honeycome magnet leads
to a quantum spin liquid (QSL) characterized by Majorana fermions, relevant for
fault-tolerant topological quantum computations.In the high-field paramagnetic
state of -RuCl, half-integer quantization of thermal Hall
conductivity has been reported as a signature of Majorana fermions, but the
bulk nature of this state remains elusive.Here, from high-resolution heat
capacity measurements under in-plane field rotation, we find strongly
angle-dependent low-energy excitations in the bulk of -RuCl. The
excitation gap has a sextuple node structure, and the gap amplitude increases
with field, exactly as expected for itinerant Majorana fermions in the Kitaev
model.Our thermodynamic results are fully linked with the transport
quantization properties, providing the first demonstration of the bulk-edge
correspondence in a Kitaev QSL.Comment: 8 pages, 7 figure
Analysis of mTOR Inhibition-Involved Pathway in Ovarian Clear Cell Adenocarcinoma
This study was designed to clarify the mechanism of the mammalian target of rapamycin (mTOR)-hypoxia inducible factor-1 (HIF-1) pathway using the cultured cell strain derived from human ovarian clear cell adenocarcinoma (CCA). Everolimus (a derivative of rapamycin)-treated cells and non-treated cells did not show any difference in mTOR expression. But, phosphorylated-mTOR (p-mTOR) expression significantly decreased in the treated cells, and mTOR-related factors such as phosphorylated-4E-BP1 (p-4E-BP1), HIF-1α, and vascular endothelial growth factor (VEGF) in the downstream region of mTOR revealed a marked decrease in expression. The analysis of influences of the drug on the HIF-1α degradation system showed an increase in von-Hippel Lindau (VHL) expression in the treated cells. Increase of cleaved caspase-3, one of key factors involved in apoptosis, was also shown in the treated cells. In the next step, using nude mice implanted with RMG-1 cells, a decrease in tumor size was demonstrated in 4 of the 7 mice which were orally administered with everolimus. As a result, it was suggested that everolimus administration would be helpful as an anti-tumor therapy for CCA not only via down-regulation of p-mTOR but also degradation of HIF-1α by VHL and induction of apoptosis by cleaved caspase-3
Time-, spin-, and angle-resolved photoemission spectroscopy with a 1-MHz 10.7-eV pulse laser
We describe a setup of time-, spin-, and angle-resolved photoemission
spectroscopy (tr-SARPES) employing a 10.7-eV (=115.6 nm) pulse laser
at 1-MHz repetition rate as a probe photon source. This equipment effectively
combines technologies of a high-power Yb:fiber laser, ultraviolet-driven
harmonic generation in Xe gas, and a SARPES apparatus equipped with
very-low-energy-electron-diffraction (VLEED) spin detectors. A high repetition
rate (1 MHz) of the probe laser allows experiments with the photoemission
space-charge effects significantly reduced, despite a high flux of 10
photons/s on the sample. The relatively high photon energy (10.7 eV) also
brings the capability of observing a wide momentum range that covers the entire
Brillouin zone of many materials while ensuring high momentum resolution. The
experimental setup overcomes a low efficiency of spin-resolved measurements,
which gets even more severe for the pump-probed unoccupied states, and affords
for investigating ultrafast electron and spin dynamics of modern quantum
materials with energy and time resolutions of 25 meV and 360 fs, respectively.Comment: 11 pages, 7 figure
Mixture models for analysis of melting temperature data
<p>Abstract</p> <p>Background</p> <p>In addition to their use in detecting undesired real-time PCR products, melting temperatures are useful for detecting variations in the desired target sequences. Methodological improvements in recent years allow the generation of high-resolution melting-temperature (T<sub>m</sub>) data. However, there is currently no convention on how to statistically analyze such high-resolution T<sub>m </sub>data.</p> <p>Results</p> <p>Mixture model analysis was applied to T<sub>m </sub>data. Models were selected based on Akaike's information criterion. Mixture model analysis correctly identified categories in T<sub>m </sub>data obtained for known plasmid targets. Using simulated data, we investigated the number of observations required for model construction. The precision of the reported mixing proportions from data fitted to a preconstructed model was also evaluated.</p> <p>Conclusion</p> <p>Mixture model analysis of T<sub>m </sub>data allows the minimum number of different sequences in a set of amplicons and their relative frequencies to be determined. This approach allows T<sub>m </sub>data to be analyzed, classified, and compared in an unbiased manner.</p
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