In vitro and vivo evaluation of C-11 labeled cinnamamidine as a new PET radioligand for NR2B/NMDA Receptors.

第５１回米国核医学会年会に参加してポスター発表（演題：NR2B/NMDA受容体の新規PETリガンドとしての炭素−１１標識シンナミジンのインビトロ及びインビボ評価）を行った。　今回の年会では、興奮性グルタミン酸受容体のPETリガンドに関して我々を含めて３件の報告があった。内、代謝性グルタミン酸受容体のPETリガンドの合成と評価の報告では、ラットでのインビボ特異結合が報告されインビボイメージング剤としての可能性が指摘され興味が持たれた。　癌のイメージングに関しては、血管新生でαVβ3インテグリンのリガンド、ヒポキシアではCu-ATSM及びFMISOの有用性評価、アポトーシスのイメージングのためのAnnexinV関連の報告が多く、臨床利用へむけての有用性が指摘されていた。The Society of Nuclear Medicine advancing molecular imagim

Imidazolylsulfonate Esters-Novel Substrate for Nucleophilic Substitutions with Fluoride Ion.

3rd Japan-China Joint Seminar on Radiopharmaceutical Chemistr

Regional Brain Distribution of 2-Deoxy-2-[F-18]fluoro-D-talose:A New PET Tracer For Measurement of Galactokinase Activity.

41st Annual Meeting of the Society of Nuclear Medicin

Effect of dissolved gas on the specific activity of N-13 labeled ions generated in water by the 16O(rho,alpha)13N reactin

A flow target system was constructed to study the chemical forms and specific activities of ions containing nitrogen-13 and non-radioactive nitrogen generated in water by the 16O(rho,alpha)13N nuclear reaction. Ulta-pure water saturated with air, hydrogen, nitrogen, oxygen, and helium gases was irradiated with 18 MeV protons (17.4MeV on traget) accelerated with a cyclotron under a fixed flow of water. The irradiated water was collected in polypropylene sampling vessels at fixed time intervals, and ions containing radioactive and non-radioactive nitrogen were analyzed by radio-ion chromatography. While the concentrations of ions containing non-radioactive nitrogen(NRNI) was below the detection limit(~100nM) in unirradiated samples regardless of the dissolved gas, they weremarkedly higher in all irradiated samples. The total concentrations of NRNI in samples saturated with various dissolved gases were 1700nM (air), 900nM (hydrogen, oxygen, helium), and 3000nM (nitrogen) at the berm current of 5muA. These results suggest that dissolved nitrogen gas is most closely related to the increase of NRNI. However, clear increases were observed also in the samples saturated with hydrogen, oxygen, and helium gases not containing nitrogen gas. From these observations, the increase of NRNI due to irradiation is considered to be primarily due to dissolved nitrogen gas but also partly due to other factors

Syntheses of (R)-and (S)-L-365,260 for PET Studies of Brain Cholecystokinin (CCK) Receptors.

41st Annual Meeting of the Society of Nuclear Medicin