5,396 research outputs found
Existence of Compact Structures in Gravity
The present paper is devoted to investigate the possible emergence of
relativistic compact stellar objects through modified gravity. For
anisotropic matter distribution, we used Krori and Barura solutions and two
notable and viable gravity formulations. By choosing particular
observational data, we determine the values of constant in solutions for three
relativistic compact star candidates. We have presented some physical behavior
of these relativistic compact stellar objects and some aspects like energy
density, radial as well as transverse pressure, their evolution, stability,
measure of anisotropy and energy conditions.Comment: 27 pages, 13 figures, version accepted for publication in European
Physical Journal
Influence of Electric Charge and Modified Gravity on Density Irregularities
This work aims to identify some inhomogeneity factors for plane symmetric
topology with anisotropic and dissipative fluid under the effects of both
electromagnetic field as well as Palatini gravity. We construct the
modified field equations, kinematical quantities and mass function to continue
our analysis. We have explored the dynamical quantities, conservation equations
and modified Ellis equations with the help of a viable model. Some
particular cases are discussed with and without dissipation to investigate the
corresponding inhomogeneity factors. For non-radiating scenario, we examine
such factors with dust, isotropic and anisotropic matter in the presence of
charge. For dissipative fluid, we investigate the inhomogeneity factor with
charged dust cloud. We conclude that electromagnetic field increases the
inhomogeneity in matter while the extra curvature terms make the system more
homogeneous with the evolution of time.Comment: 28 pages, no figure, version accepted for publication in European
Physical Journal
Mobile Advertising Technology Acceptance Model (M-TAM): An Extension of TAM in Mobile Marketing Context
Mobile advertising technology has revolutionized the way companies interact with their customers. This has offered both marketers and consumers the advantages of convenience, flexibility, and ubiquity etc. Irrespective of the advantages of mobile advertising technology, it is not easy for marketers and researchers to form adoptable mobile advertising technology for consumers without being in a position to precisely foresee consumers’ behavioural outcome. Additionally, this field appears to be scant in academic researches. The current study was initiated to empirically
examine the influence of m-advertising technological factors (i.e., ease of use, usefulness, personalization and credibility) on consumers’ adoption behaviour. These factors were also mediated by emotional value in order to influence end users’ adoption behaviour. A quantitative approach based
upon a cross-sectional administered survey was employed to collect the data from university going student as respondents. The Partial Least Square (PLS) two step path modelling was used through SmartPLS 3 to test the direct and indirect hypotheses. The results indicate that mobile advertising
technology factors (i.e., ease of use, usefulness, personalization and credibility) directly and indirectly impact consumers’ adoption behaviour through emotional value. Based on the findings of the study, theoretical and practical contributions along with certain limitations and future researches recommendation are discussed consequentially
Targeted therapies to improve CFTR function in cystic fibrosis
Cystic fibrosis is the most common genetically determined, life-limiting disorder in populations of European ancestry. The genetic basis of cystic fibrosis is well established to be mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for an apical membrane chloride channel principally expressed by epithelial cells. Conventional approaches to cystic fibrosis care involve a heavy daily burden of supportive treatments to combat lung infection, help clear airway secretions and maintain nutritional status. In 2012, a new era of precision medicine in cystic fibrosis therapeutics began with the licensing of a small molecule, ivacaftor, which successfully targets the underlying defect and improves CFTR function in a subgroup of patients in a genotype-specific manner. Here, we review the three main targeted approaches that have been adopted to improve CFTR function: potentiators, which recover the function of CFTR at the apical surface of epithelial cells that is disrupted in class III and IV genetic mutations; correctors, which improve intracellular processing of CFTR, increasing surface expression, in class II mutations; and production correctors or read-through agents, which promote transcription of CFTR in class I mutations. The further development of such approaches offers great promise for future therapeutic strategies in cystic fibrosis
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