165 research outputs found

    Timber gridshells: beyond the drawing board

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    In March 2011, a week-long workshop that invited participation from all architecture and architectural technology students at Sheffield Hallam University, UK was organised with the objective of enhancing students’ thinking and experience by construction thinking. It was aimed at creating a sense of realness to realise a design project collectively. Timber was set as the material of exploration. The students had to make use of bending to design and create a timber gridshell structure. This made use of a quality traditionally felt to be a structural weakness of the material. To do this, students form-found non-mathematically and non-digitally using paper gridmats. This paper describes the aims, activity and outcome of the timber gridshell workshop as a way of preparing architects and technologists of the future and introducing the challenges of architectural design in terms of economics and construction process, aesthetics, effective communication and structural intuition by working with a given material – all important aspects in achieving effective architecture

    The status of the world's land and marine mammals: diversity, threat, and knowledge

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    Knowledge of mammalian diversity is still surprisingly disparate, both regionally and taxonomically. Here, we present a comprehensive assessment of the conservation status and distribution of the world's mammals. Data, compiled by 1700+ experts, cover all 5487 species, including marine mammals. Global macroecological patterns are very different for land and marine species but suggest common mechanisms driving diversity and endemism across systems. Compared with land species, threat levels are higher among marine mammals, driven by different processes (accidental mortality and pollution, rather than habitat loss), and are spatially distinct (peaking in northern oceans, rather than in Southeast Asia). Marine mammals are also disproportionately poorly known. These data are made freely available to support further scientific developments and conservation action

    The mammals of Angola

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    Scientific investigations on the mammals of Angola started over 150 years ago, but information remains scarce and scattered, with only one recent published account. Here we provide a synthesis of the mammals of Angola based on a thorough survey of primary and grey literature, as well as recent unpublished records. We present a short history of mammal research, and provide brief information on each species known to occur in the country. Particular attention is given to endemic and near endemic species. We also provide a zoogeographic outline and information on the conservation of Angolan mammals. We found confirmed records for 291 native species, most of which from the orders Rodentia (85), Chiroptera (73), Carnivora (39), and Cetartiodactyla (33). There is a large number of endemic and near endemic species, most of which are rodents or bats. The large diversity of species is favoured by the wide range of habitats with contrasting environmental conditions, while endemism tends to be associated with unique physiographic settings such as the Angolan Escarpment. The mammal fauna of Angola includes 2 Critically Endangered, 2 Endangered, 11 Vulnerable, and 14 Near-Threatened species at the global scale. There are also 12 data deficient species, most of which are endemics or near endemics to the countryinfo:eu-repo/semantics/publishedVersio

    Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

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    THE BACTERIAL OXIDATION OF PHENYLACETIC ACID

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    The bacterial oxidation of aromatic compounds closely related in chemical structure may proceed by different pathways. Thus, while the main features of the breakdown of mandelic acid are established, those of phenylacetate are not, except insofar as it is known to follow a different route (Stanier, 1950). The di-vergencies may possibly indicate a difference in the mode of ring fission; and since it is established that mandelic acid and certain other aromatic compounds give rise to,-ketoadipic acid (Kilby, 1948, 1951; Stanier, 1950), we have in-vestigated the production of keto acids in phenylacetate metabolism. At the same time we have attempted to determine whether the reactions of the tri-carboxylic acid cycle play a part in these oxidations, and whether there is any evidence under favorable conditions for an abridged cycle as postulated by Barron, Ardao, and Hearon (1950) for Corynebacterium creatinovorans and termed by them the "dicarboxylic acid cycle". Pyruvic acid accumulates in aerated cultures of Aerobacter aerogenes growing on glucose or various dicarboxylic acids only when its rate of production exceed
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