Cr-Mn-Fe-Co-Ni系高エントロピー合金データベースの開発

要約のみTohoku University及川勝成課

Multifunctional control design for modular plug-and-play battery storage in DC microgrids

Plug-and-Play (P&P) performance facilitates the modularity of DC microgrids. The realization of P&P operation relies on the control design of DC microgrids. Conventional control methods are normally designed for steady operation of a DC microgrid, neglecting or partially sacrifices the availability of P&P operations. Some bottom layer’s control designs such as droop control, from a hierarchical control scheme perspective for example, are inherently able to realize P&P operations. However, such methods have limitations in terms of power sharing accuracy. This paper proposes a control scheme that reconfigures hierarchical control and makes it more compatible for different P&P operation situations in DC microgrids. In this control scheme, Automatic Mater-Slave (AMS) control is implemented in the secondary control layer to automatically respond to those cases in the absence of communication or the failure of the master module. The proposed control scheme is validated by MATLAB/Simulink simulation

Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis

BackgroundBiliary tract cancer (BTC) is a malignancy associated with unfavorable outcomes. Advanced BTC patients have a propensity to experience compromised immune and nutritional status as a result of obstructive jaundice and biliary inflammation. Currently, there is a lack of consensus on the impact of the Controlling Nutritional Status (CONUT) score in the context of BTC prognosis. The purpose of this study is to conduct a meta-analysis on the association between CONUT and the prognosis of patients suffering from BTC.MethodsA defined search strategy was implemented to search the PubMed, Embase, and Web of Science databases for eligible studies published until March 2023, with a focus on overall survival (OS), relapse-free survival/recurrence-free survival(RFS), and relevant clinical characteristics. The prognostic potential of the CONUT score was evaluated using hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs).ResultsIn this meta-analysis, a total of 1409 patients from China and Japan were involved in 9 studies. The results indicated that the CONUT score was significantly correlated with worse OS (HR=2.13, 95% CI 1.61-2.82, P<0.0001) and RFS (HR=1.83, 95% CI 1.44–2.31, P<0.0001) in patients with BTC. And, the analysis showed that a high CONUT score was significantly associated with clinical characteristics such as jaundice (OR=1.60, 95% CI=1.14–2.25, P=0.006), poorly differentiated tumor (OR=1.43, 95% CI=1.03–1.99, P=0.03), pT3 and 4 stage of the tumor (OR=1.87, 95% CI=1.30–2.68, P=0.0007), and complications of Clavien-Dindo classification grade IIIa or higher (OR=1.79, 95% CI=1.03–3.12, P=0.04).ConclusionThis meta-analysis indicates that a high CONUT score can serve as a significant prognostic indicator for survival outcomes among patients diagnosed with BTC

Reconstructed droop control for peer current sharing of battery storage in DC microgrids

Droop control has been widely applied in DC microgrids for regulating the power sharing of battery storage. However, conventional droop control needs to select appreciate droop coefficients and large droop coefficients could have the potential to change the system quiescent operating point, thus causing instability. To solve such concern, this paper proposes a novel droop control realization with a natural droop coefficient. A reconstructed control block is used to achieve this purpose. The reconstructed control block also generates a controllable variable for integrating with hierarchical control scheme. Besides, this variable enhances the stability performance of converter due to variable load-adjusted bandwidth of controller. Numerical analysis is provided to visually inspect to the relationship between the bandwidth of controller and load power. A Matlab/simulink model is used to validate this novel reconstructed droop control.</div

PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway

Mitochondrial apoptosis is one of the main mechanisms for cancer cells to overcome chemoresistance. Hexokinase 2 (HK2) can resist cancer cell apoptosis by expressing on mitochondria and binding to voltage-dependent anion channel 1 (VDAC1). We previously reported that peroxisome proliferator-activated receptor coactivator 1 α (PGC1α) is highly expressed in ovarian cancer cisplatin-resistant cells. However, the underlying mechanism remains unclear. Therefore, we evaluated the interaction between PGC1α and HK2 in ovarian cancer cisplatin-resistant cells. We found that the knockdown of PGC1α promotes the apoptosis of ovarian cancer cisplatin-resistant cells and increases their sensitivity to cisplatin. In addition, we found that the knockdown of PGC1α affects the mitochondrial membrane potential and the binding of HK2 and VDAC1. As the heat shock protein 70 (HSP70) family can help protein transport, we detected it and found that PGC1α can promote HSP70 gene transcription. Furthermore, HSP70 can promote an increase of HK2 expression on mitochondria and an increase of binding to VDAC1. Based on these results, PGC1α may reduce apoptosis through the HSP70/HK2/VDAC1 signaling pathway, thus promoting cisplatin resistance of ovarian cancer. These findings provide strong theoretical support for PGC1α as a potential therapeutic target of cisplatin resistance in ovarian cancer

PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway

Mitochondrial apoptosis is one of the main mechanisms for cancer cells to overcome chemoresistance. Hexokinase 2 (HK2) can resist cancer cell apoptosis by expressing on mitochondria and binding to voltage-dependent anion channel 1 (VDAC1). We previously reported that peroxisome proliferator-activated receptor coactivator 1 α (PGC1α) is highly expressed in ovarian cancer cisplatin-resistant cells. However, the underlying mechanism remains unclear. Therefore, we evaluated the interaction between PGC1α and HK2 in ovarian cancer cisplatin-resistant cells. We found that the knockdown of PGC1α promotes the apoptosis of ovarian cancer cisplatin-resistant cells and increases their sensitivity to cisplatin. In addition, we found that the knockdown of PGC1α affects the mitochondrial membrane potential and the binding of HK2 and VDAC1. As the heat shock protein 70 (HSP70) family can help protein transport, we detected it and found that PGC1α can promote HSP70 gene transcription. Furthermore, HSP70 can promote an increase of HK2 expression on mitochondria and an increase of binding to VDAC1. Based on these results, PGC1α may reduce apoptosis through the HSP70/HK2/VDAC1 signaling pathway, thus promoting cisplatin resistance of ovarian cancer. These findings provide strong theoretical support for PGC1α as a potential therapeutic target of cisplatin resistance in ovarian cancer

Comprehensive local control design for eliminating line resistance effect on power sharing degradation in DC microgrids

In droop-controlled DC microgrids, parasitic resistances of long conductive lines introduce additional terms for the power calculation and impact the power sharing accuracy. This paper proposed a comprehensive local control design for enhancing power sharing accuracy and restoring DC bus voltage while increasing stability performance in DC microgrids. A passive controller is used in the primary control to ensure the sufficient bandwidth of controller in case of frequent operation modes alteration and voltage deviation in the DC microgrid. A concept of Virtual Negative Line Resistance (VNLR) is used in the secondary control layer to compensate the real line resistance such that line resistance no longer degrades power sharing accuracy. The common DC bus voltage needs to be monitored in the proposed secondary controller. Simultaneously, the common DC bus voltage can be restored as the designed value. The monitored DC bus voltage signal is filtered by a designed low-pass filter such that mid-high frequency dynamics can be decoupled between secondary controls and primary controls. Then the entire local control scheme relaxes three Degrees of Freedom (DoF) which can be used for upper layer controls. Finally, the proposed control method has been experimentally validated in a 50V DC microgrid laboratory testing system

Data for paper "Comprehensive Local Control Design for Eliminating Line Resistance Effect on Power Sharing Degradation in DC Microgrids"

This data is for a paper:Comprehensive Local Control Design for Eliminating Line Resistance Effect on Power Sharing Degradation in DC Microgrids, IET Power Electronics, 2021https://doi.org/10.1049/pel2.12208 </div