Izraženost surfaktantnog proteina B u bronhoalveolarnom ispirku terminske novorođenčadi sa sindromom respiracijskog distresa

The aim was to investigate the surfactant protein B (SP-B) expression in the bronchoalveolar lavage fluid (BALF ) of full-term neonates with respiratory distress syndrome (RD S). The enzyme-linked immunosorbent assay was performed to assess SP-B expression in BALF of 60 full-term neonates with RD S and 23 healthy neonates and correlation of SP-B level with RD S classification according to chest x-ray findings and PaO2/FiO2 before mechanical ventilation in neonates with RD S. The SP-B level was significantly lower in the RD S group (17.63±6.80 ng/mL) than in healthy neonates (103.95±6.38 ng/mL) (P<0.001). The SP-B level correlated positively with PaO2/ FiO2 before mechanical ventilation (r=0.838, P<0.001). Moreover, the lower the SP-B level, the more severe was the RD S as determined by chest x-ray (P<0.001). In conclusion, full-term neonates with RD S had reduced SP-B in BALF , which was related to the severity of RD S, suggesting that SP-B supplement may be an effective strategy in the treatment of RD S in full-term neonates.Cilj studije bio je ispitati izraženost surfaktantnog proteina B (SP-B) u bronhoalveolarnom ispirku (BALF ) terminske novorođenčadi sa sindromom respiracijskog distresa (SRD ). Izraženost SP-B određena je testom ELI SA u BALF 60 terminske novorođenčadi sa SRD i 23 zdrave novorođenčadi. Utvrđena je korelacija razine SP-B s klasifikacijom SRD prema rendgenskoj snimci prsišta i vrijednosti PaO2/FiO2 prije mehaničke ventilacije u novorođenčadi sa SRD . U skupini novorođenčadi sa SRD razina SP-B bila je značajno niža (17,63±6,80 ng/mL) od one u zdrave novorođenčadi (103,95±6,38 ng/ mL) (P<0,001). Utvrđena je pozitivna korelacija razine SP-B i PaO2/FiO2 prije mehaničke ventilacije (r=0,838, P<0,001). Štoviše, što je bila niža razina SP-B, to je teži bio SRD procijenjen prema rendgenskoj snimci prsišta (P<0,001). Zaključuje se da terminska novorođenčad sa SRD ima sniženu razinu SP-B u BALF i to je povezano s težinom SRD . Ovi nalazi ukazuju na to da bi dodatak SP-B mogla biti učinkovita strategija u liječenju SRD kod terminske novorođenčadi

A self-starting bi-chromatic LiNbO_3 soliton microcomb

The wide range of functions that are possible with lithium niobate (LN) waveguide devices, including phase and intensity modulation, second-harmonic generation, and difference-frequency generation, makes it attractive as a potential microcomb material. LN microcombs would combine essential comb self-referencing and control functions with the pulse generation process in a single microresonator device. Here, we demonstrate a soliton microcomb in a monolithic high-Q LN resonator. Direct frequency doubling of the soliton spectrum is observed inside the same cavity. The LN soliton mode-locking process also self-starts and allows bi-directional switching of soliton states, effects that are shown to result from the LN photorefractive effect. The Kerr solitons exhibit a self-frequency shift resulting from the Raman effect of LN. This microcomb platform can dramatically simplify miniature time keeping, frequency synthesis/division, and spectroscopy systems. Moreover, direct generation of femtosecond timescale pulses within LN microresonators can benefit quantum photonics and signal processing systems

A self-starting bi-chromatic LiNbO_3 soliton microcomb

The wide range of functions that are possible with lithium niobate (LN) waveguide devices, including phase and intensity modulation, second-harmonic generation, and difference-frequency generation, makes it attractive as a potential microcomb material. LN microcombs would combine essential comb self-referencing and control functions with the pulse generation process in a single microresonator device. Here, we demonstrate a soliton microcomb in a monolithic high-Q LN resonator. Direct frequency doubling of the soliton spectrum is observed inside the same cavity. The LN soliton mode-locking process also self-starts and allows bi-directional switching of soliton states, effects that are shown to result from the LN photorefractive effect. The Kerr solitons exhibit a self-frequency shift resulting from the Raman effect of LN. This microcomb platform can dramatically simplify miniature time keeping, frequency synthesis/division, and spectroscopy systems. Moreover, direct generation of femtosecond timescale pulses within LN microresonators can benefit quantum photonics and signal processing systems

Ultra-low-dose spectral-detector computed tomography for the accurate quantification of pulmonary nodules: an anthropomorphic chest phantom study

PURPOSETo assess the quantification accuracy of pulmonary nodules using virtual monoenergetic images (VMIs) derived from spectral-detector computed tomography (CT) under an ultra-low-dose scan protocol.METHODSA chest phantom consisting of 12 pulmonary nodules was scanned using spectral-detector CT at 100 kVp/10 mAs, 100 kVp/20 mAs, 120 kVp/10 mAs, and 120 kVp/30 mAs. Each scanning protocol was repeated three times. Each CT scan was reconstructed utilizing filtered back projection, hybrid iterative reconstruction, iterative model reconstruction (IMR), and VMIs of 40–100 keV. The signal-to-noise ratio and air noise of images, absolute differences, and absolute percentage measurement errors (APEs) of the diameter, density, and volume of the four scan protocols and ten reconstruction images were compared.RESULTSWith each fixed reconstruction image, the four scanning protocols exhibited no significant differences in APEs for diameter and density (all P > 0.05). Of the four scan protocols and ten reconstruction images, APEs for nodule volume had no significant differences (all P > 0.05). At 100 kVp/10 mAs, APEs for density using IMR were the lowest (APE-mean: 6.69), but no significant difference was detected between VMIs at 50 keV (APE-mean: 11.69) and IMR (P = 0.666). In the subgroup analysis, at 100 kVp/10 mAs, there were no significant differences between VMIs at 50 keV and IMR in diameter and density (all P > 0.05). The radiation dose at 100 kVp/10 mAs was reduced by 77.8% compared with that at 120 kVp/30 mAs.CONCLUSIONCompared with IMR, reconstruction at 100 kVp/10 mAs and 50 keV provides a more accurate quantification of pulmonary nodules, and the radiation dose is reduced by 77.8% compared with that at 120 kVp/30 mAs, demonstrating great potential for ultra-low-dose spectral-detector CT

Izraženost surfaktantnog proteina B u bronhoalveolarnom ispirku terminske novorođenčadi sa sindromom respiracijskog distresa

The aim was to investigate the surfactant protein B (SP-B) expression in the bronchoalveolar lavage fluid (BALF ) of full-term neonates with respiratory distress syndrome (RD S). The enzyme-linked immunosorbent assay was performed to assess SP-B expression in BALF of 60 full-term neonates with RD S and 23 healthy neonates and correlation of SP-B level with RD S classification according to chest x-ray findings and PaO2/FiO2 before mechanical ventilation in neonates with RD S. The SP-B level was significantly lower in the RD S group (17.63±6.80 ng/mL) than in healthy neonates (103.95±6.38 ng/mL) (P<0.001). The SP-B level correlated positively with PaO2/ FiO2 before mechanical ventilation (r=0.838, P<0.001). Moreover, the lower the SP-B level, the more severe was the RD S as determined by chest x-ray (P<0.001). In conclusion, full-term neonates with RD S had reduced SP-B in BALF , which was related to the severity of RD S, suggesting that SP-B supplement may be an effective strategy in the treatment of RD S in full-term neonates.Cilj studije bio je ispitati izraženost surfaktantnog proteina B (SP-B) u bronhoalveolarnom ispirku (BALF ) terminske novorođenčadi sa sindromom respiracijskog distresa (SRD ). Izraženost SP-B određena je testom ELI SA u BALF 60 terminske novorođenčadi sa SRD i 23 zdrave novorođenčadi. Utvrđena je korelacija razine SP-B s klasifikacijom SRD prema rendgenskoj snimci prsišta i vrijednosti PaO2/FiO2 prije mehaničke ventilacije u novorođenčadi sa SRD . U skupini novorođenčadi sa SRD razina SP-B bila je značajno niža (17,63±6,80 ng/mL) od one u zdrave novorođenčadi (103,95±6,38 ng/ mL) (P<0,001). Utvrđena je pozitivna korelacija razine SP-B i PaO2/FiO2 prije mehaničke ventilacije (r=0,838, P<0,001). Štoviše, što je bila niža razina SP-B, to je teži bio SRD procijenjen prema rendgenskoj snimci prsišta (P<0,001). Zaključuje se da terminska novorođenčad sa SRD ima sniženu razinu SP-B u BALF i to je povezano s težinom SRD . Ovi nalazi ukazuju na to da bi dodatak SP-B mogla biti učinkovita strategija u liječenju SRD kod terminske novorođenčadi

GAM-Based Mooring Alignment for SINS Based on An Improved CEEMD Denoising Method

To solve the self-alignment problem of the Strapdown Inertial Navigation System (SINS), a novel adaptive filter based on Complementary Ensemble Empirical Mode Decomposition (CEEMD) is proposed. The Gravitational Apparent Motion (GAM) is used in the coarse alignment, and the problem of obtaining the attitude matrix between the body frame and the navigation frame is attributed to obtaining the matrix between the initial body frame and the current navigation frame using two gravitational apparent motion vectors at different moments. However, the accuracy and time of this alignment method always suffer from the measurement noise of sensors. Thus, a novel adaptive filter based on CEEMD using an l 2 -norm to calculate the similarity measure between the Probability Density Function (PDF) of each Intrinsic Mode Function (IMF) and the original signal is proposed to denoise the measurements of the accelerometer. Furthermore, the advantage of this filter is verified by comparing with other conventional denoising methods, such as PDF-based EMD (EMD-PDF) and the Finite Impulse Response (FIR) digital low-pass filter method. The results of the simulation and experiments indicate that the proposed method performs better than the conventional methods in both alignment time and alignment accuracy

Enhanced Ultraviolet Damage Resistance in Magnesium Doped Lithium Niobate Crystals through Zirconium Co-Doping

MgO-doped LiNbO3 (LN:Mg) is famous for its high resistance to optical damage, but this phenomenon only occurs in visible and infrared regions, and its photorefraction is not decreased but enhanced in ultraviolet region. Here we investigated a series of ZrO2 co-doped LN:Mg (LN:Mg,Zr) regarding their ultraviolet photorefractive properties. The optical damage resistance experiment indicated that the resistance against ultraviolet damage of LN:Mg was significantly enhanced with increased ZrO2 doping concentration. Moreover, first-principles calculations manifested that the enhancement of ultraviolet damage resistance for LN:Mg,Zr was mainly determined by both the increased band gap and the reduced ultraviolet photorefractive center O2−/−. So, LN:Mg,Zr crystals would become an excellent candidate for ultraviolet nonlinear optical material

EXPRESSION OF PULMONARY SURFACTANT-ASSOCIATED PROTEIN B IN NEONATAL RESPIRATORY DISTRESS SYNDROME EKSPRESIJA PLU]NOG SURFAKTANT-VEZANOG PROTEINA B U SINDROMU NEONATALNOG RESPIRATORNOG DISTRESA

Summary Background: The aim of this study was to investigate the role of pulmonary surfactant-associated protein B (SP-B) expression in the pathogenesis of neonatal respiratory distress syndrome (RDS) via detecting the protein and mRNA expression of SP-B. Methods: A total of 60 unrelated neonates who died of RDS were chosen as the RDS group and then subgrouped into ≤32 weeks group, 32∼37 weeks group and ≥37 weeks group (n=20). Sixty neonates who died of other diseases were enrolled as controls and subdivided into 3 matched groups based on the gestational age. Western blot assay and RT-PCR were employed. Results: In the RDS group, SP-B protein expression was reduced or deficient in 8 neonates of which 6 had no SP-B protein expression. In the control group, only 1 had reduced SP-B protein expression. The reduced or deficient SP-B protein expression in 9 neonates of both groups was noted in the ≥37 weeks group. In the RDS group, the SP-B mRNA expression was significantly lower than that in the control group. In the ≤37 weeks group, SP-B mRNA expression was comparable between the RDS group and control group. In the 32∼37 weeks group, the SP-B mRNA expression in the RDS group was significantly reduced when compared with the control group. In the ≥37 weeks group, the SP-B mRNA expression in the RDS group was dramatically lower than that in the control group. Conclusions: Alteration of SP-B expression is present at transcriptional and translational levels. Reduction of SP-B mRNA and protein expression is involved in the pathogenesis of RDS