Radiation hardness study of BC408 plastic scintillator under 80 MeV proton beam irradiations

To investigate the 1.6 GeV high-energy proton beam detector utilized in the CSNS Phase-II upgrade project, a plastic scintillator detector presents a viable option due to its superior radiation hardness. This study investigates the effects of irradiation damage on a BC408 plastic scintillator induced by 80 MeV protons, including absorption and fluorescence spectroscopy, and light yield tests of BC408 pre- and post-proton irradiation, with a focus on determining the radiation resistance threshold of BC408. The results indicate that the performance of BC408 remains unimpaired at absorbed doses up to 5.14*10^3 Gy/cm3, demonstrating its ability to absorb 1.63*10^13 p/cm3 1.6 GeV protons while maintaining stability. This suggests that BC408 could potentially be used as the 1.6 GeV high-energy proton beam detector in the CSNS Phase-II upgrade project

High precision proton beam monitor system concept design on CSNS based on SiC

A high precision beam monitor system based on silicon carbide PIN sensor is designed for China Spallation Neutron Source 1.6 GeV proton beam to monitor the proton beam fluence.The concept design of the beam monitor system is finished together with front-end electronics with silicon carbide PIN sensors, readout system and mechanical system.Several tests are performed to study the performance of each component of the system.The charge collection of the SiC PIN sensors after proton radiation is studied with 80 MeV proton beam for continuous running. Research on the performance of the front-end electronics and readout system is finished for better data acquisition.The uncertainty of proton beam fluence is below 1% in the beam monitor system

Aptamer Technology and Its Applications in Bone Diseases

Aptamers are single-stranded nucleic acids (DNA, short RNA, or other artificial molecules) produced by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology, which can be tightly and specifically combined with desired targets. As a comparable alternative to antibodies, aptamers have many advantages over traditional antibodies such as a strong chemical stability and rapid bulk production. In addition, aptamers can bind targets in various ways, and are not limited like the antigen–antibody combination. Studies have shown that aptamers have tremendous potential to diagnose and treat clinical diseases. However, only a few aptamer-based drugs have been used because of limitations of the aptamers and SELEX technology. To promote the development and applications of aptamers, we present a review of the methods optimizing the SELEX technology and modifying aptamers to boost the selection success rate and improve aptamer characteristics. In addition, we review the application of aptamers to treat bone diseases

Neutron beam line design of a white neutron source at CSNS

China Spallation Neutron Source (CSNS), which is under construction, is a large scientific facility dedicated mainly for multi-disciplinary research on material characterization using neutron scattering techniques. The CSNS Phase-I accelerator will deliver a proton beam with an energy of 1.6 GeV and a pulse repetition rate of 25 Hz to a tungsten target, and the beam power is 100 kW. A white neutron source using the back-streaming neutrons through the incoming proton beam channel was proposed and is under construction. The back-streaming neutrons which are very intense and have good time structure are very suitable for nuclear data measurements. The white neutron source includes an 80-m neutron beam line, two experimental halls, and also six different types of spectrometers. The physics design of the beam line is presented in this paper, which includes beam optics and beam characterization simulations, with the emphasis on obtaining extremely low background. The first-batch experiments on nuclear data measurements are expected to be conducted in late 2017

Neutron beam line design of a white neutron source at CSNS

China Spallation Neutron Source (CSNS), which is under construction, is a large scientific facility dedicated mainly for multi-disciplinary research on material characterization using neutron scattering techniques. The CSNS Phase-I accelerator will deliver a proton beam with an energy of 1.6 GeV and a pulse repetition rate of 25 Hz to a tungsten target, and the beam power is 100 kW. A white neutron source using the back-streaming neutrons through the incoming proton beam channel was proposed and is under construction. The back-streaming neutrons which are very intense and have good time structure are very suitable for nuclear data measurements. The white neutron source includes an 80-m neutron beam line, two experimental halls, and also six different types of spectrometers. The physics design of the beam line is presented in this paper, which includes beam optics and beam characterization simulations, with the emphasis on obtaining extremely low background. The first-batch experiments on nuclear data measurements are expected to be conducted in late 2017