39 research outputs found
Pharmakologisch aktive Inhaltsstoffe aus Pilzen Abschlussbericht
No full textSubstances have been separated from fungi by organic solvent extraction. In the case of biologic activity, isolation was carried out mainly by fermentation and preparative chromatography. Purity and molecular structure were determined by spectroscopic methods. Numerous drugs have been found which exhibit pharmacological activity and are of interests in the fields of allergy, immunology, thrombocyte aggregation, inotropy and vascular relaxation, disordered fat-metabolism and as antiretrovitale substances. (WEN)SIGLEAvailable from TIB Hannover: F94B1720+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman
ChemInform Abstract: Nucleic Acid Related Compounds. Part 66. Improved Syntheses of 5′- Chloro-5′-deoxy- and 5′-S-Aryl(or Alkyl)-5′-thionucleosides.
No full textChemInform Abstract: Nucleic Acid Related Compounds. Part 96. Synthesis of Sugar-Modified 2, 6-Diaminopurine and Guanine Nucleosides from Guanosine via Transformations of 2-Aminoadenosine and Enzymatic Deamination with Adenosine Deaminase.
No full textNucleic Acid Related Compounds. Part 66. Improved Syntheses of 5′- Chloro-5′-deoxy- and 5′-S-Aryl(or Alkyl)-5′-thionucleosides.
No full text
Synthesis of sugar-modified 2,6-diaminopurine and guanine nucleosides from guanosine via transformations of 2-aminoadenosine and enzymatic deamination with adenosine deaminase
No full textNucleic acid related compounds. 66. Improved syntheses of 5′-chloro-5′-deoxy- and 5′-S-aryl(or alkyl)-5′-thionucleosides
No full textEinsatz molekularbiologischer Testsysteme bei der Suche nach pharmakologisch aktiven Naturstoffen Abschlussbericht
No full textThe aim of the consortium project is the search for new pharmacologically active natural products of potentially therapeutic relevance. Based on the latest molecular pharmacological knowledge promissing targets are identified and transformed into in-vitro test systems relevant for the therapeutic areas: cardiovascular, autoimmune and neuro-degenerative diseases, diabetes, inflammation, oncology and bone metabolism. The main focus is put on signal transduction, G-protein coupled receptors, protein kinases and neurotrophins. As very promissing source fuer novel lead structures/drugs microorganisms like basidio-, asco-, deutero-, zygo- and myxomycetes, 'rare', actinomycetes and marine microorganisms are used because of their extraordinary biological variety and the very distinct structural diversity of their secondary metabolites. (orig.)SIGLEAvailable from TIB Hannover: F98B1533+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman
Synthesis of sugar-modified 2,6-diaminopurine and guanine nucleosides from guanosine via transformations of 2-aminoadenosine and enzymatic deamination with adenosine deaminase
No full text
