Spectroscopic study of the elusive globular cluster ESO452-SC11 and its surroundings

Globular clusters (GCs) are amongst the oldest objects in the Galaxy and play a pivotal role in deciphering its early history. We present the first spectroscopic study of the GC ESO452-SC11 using the AAOmega spectrograph at medium resolution. Given the sparsity of this object and high degree of foreground contamination due to its location toward the bulge, few details are known for this cluster: there is no consensus of its age, metallicity, or its association with the disk or bulge. We identify 5 members based on radial velocity, metallicity, and position within the GC. Using spectral synthesis, accurate abundances of Fe and several $\alpha$-, Fe-peak, neutron-capture elements (Si,Ca,Ti,Cr,Co,Ni,Sr,Eu) were measured. Two of the 5 cluster candidates are likely non-members, as they have deviant Fe abundances and [$\alpha$/Fe] ratios. The mean radial velocity is 19$\pm$2 km s$^{-1}$ with a low dispersion of 2.8$\pm$3.4 km s$^{-1}$, in line with its low mass. The mean Fe-abundance from spectral fitting is $-0.88\pm0.03$, with a spread driven by observational errors. The $\alpha$-elements of the GC candidates are marginally lower than expected for the bulge at similar metallicities. As spectra of hundreds of stars were collected in a 2 degree field around ESO452-SC11, detailed abundances in the surrounding field were measured. Most non-members have higher [$\alpha$/Fe] ratios, typical of the nearby bulge population. Stars with measured Fe-peak abundances show a large scatter around Solar values, though with large uncertainties. Our study provides the first systematic measurement of Sr in a Galactic bulge GC. The Eu and Sr abundances of the GC candidates are consistent with a disk or bulge association. Our calculations place ESO452 on an elliptical orbit in the central 3 kpc of the bulge. We find no evidence of extratidal stars in our data. (Abridged)Comment: 10 pages, 13 figures, accepted for publication in Astronomy & Astrophysic

A high-precision abundance analysis of the nuclear benchmark star HD 20

We present our chemical abundance investigation of the metal-poor ([Fe/H]=-1.60 dex), r-process-enriched ([Eu/Fe]=0.73 dex) halo star HD 20 using novel and archival high-resolution spectra at outstanding signal-to-noise ratios. By combining one of the first asteroseismic gravity measurements in the metal-poor regime from a TESS light curve with non-LTE analyses of iron lines, we derive a set of highly accurate and precise stellar parameters. These allow us to delineate a chemical pattern comprised of solid detections of 48 elements, including 28 neutron-capture elements, which establishes HD 20 among the few benchmark stars that have almost complete patterns with low systematic dependencies on the stellar parameters. Our light-element (Z<30) abundances are representative of other, similarly metal-poor stars in the Galactic halo with contributions from core-collapse supernovae of type II. A comparison to the scaled solar r-pattern shows that the lighter neutron-capture elements (37<Z<60) are poorly matched. In particular, we find imprints of the weak r-process acting at low metallicities. Nonetheless, by comparing our detailed abundances to the observed metal-poor star BD +17 3248, we find a persistent residual pattern that is indicative of enrichment contributions from the s-process. We show that mixing with material from predicted yields of massive, rotating AGB stars at low metallicity considerably improves the fit. Based on a solar ratio of heavy- to light-s elements -- at odds with model predictions for the i-process -- and a missing clear residual pattern with respect to other stars with claimed contributions from this process, we refute (strong) contributions from such astrophysical sites providing intermediate neutron densities. Finally, nuclear cosmochronology is used to tie our detection of the radioactive element Th to an age estimate for HD 20 of $11.0\pm3.8$ Gyr. [abridged]Comment: 23 pages (+10 pages appendix), 27 figures, 8 tables, revised version resubmitted to A&

The Gaia-ESO survey: 3D NLTE abundances in the open cluster NGC 2420 suggest atomic diffusion and turbulent mixing at the origin of chemical abundance variations

Atomic diffusion and mixing processes in stellar interiors influence the structure and the surface composition of stars. Some of these processes cannot yet be modelled from the first principles. This limits their applicability in stellar models used for studies of stellar populations and Galactic evolution. Our main goal is to put constrains on the stellar structure and evolution models using new refined measurements of chemical composition in stars of Galactic open cluster. We use medium-resolution, 19 200 <= R <= 21 500, optical spectra of the stars in the open cluster NGC 2420 obtained within the Gaia-ESO survey. The sample covers all evolutionary stages from the main-sequence to red giant branch. Stellar parameters are derived using a combined Bayesian analysis of spectra, 2MASS photometry, and astrometric data from Gaia DR2. The abundances of Mg, Ca, Fe, and Li are determined from non-local thermodynamic equilibrium (NLTE) synthetic spectra, computed using one-dimensional (1D) and averaged three-dimensional (3D) model atmospheres. We compare our results with a grid of Code d'Evolution Stellaire Adaptatif et Modulaire (CESTAM) stellar evolution models, which include atomic diffusion, turbulent and rotational mixing. We find prominent evolutionary trends in the abundances of Fe, Ca, Mg, and Li with the mass of the stars in the cluster. Fe, Mg, and Ca show a depletion at the cluster turn-off, but the abundances gradually increase and flatten near the base of the RGB. The abundance trend for Li displays a signature of rotational mixing on the main-sequence and abrupt depletion on the subgiant branch, which is caused by advection of Li-poor material to the surface. The analysis of abundances combined with the CESTAM model predictions allows us to place limits on the parameter space of the models and to constrain the zone in the stellar interior where turbulent mixing takes place.Comment: accepted for publication in A&

Effects of the peripherally acting μ-opioid receptor antagonist methylnaltrexone on acute pancreatitis severity:study protocol for a multicentre double-blind randomised placebo-controlled interventional trial, the PAMORA-AP trial

BACKGROUND: Moderate to severe acute pancreatitis (AP) is associated with a high rate of complications and increased mortality, yet no targeted pharmacologic treatment currently exists. As pain is a dominant symptom in AP, patients are exposed to excess levels of both endo- and exogenous opioids, which may have harmful effects on the course of AP. This trial investigates the effects of the peripherally acting μ-opioid receptor antagonist (PAMORA) methylnaltrexone on disease severity and clinical outcomes in patients with moderate to severe AP. METHODS: PAMORA-AP is a multicentre, investigator-initiated, double-blind, randomised, placebo-controlled, interventional trial, which will be conducted at four referral centres for acute pancreatitis in Denmark. Ninety patients with early-onset AP (pain onset within 48 h) as well as predicted moderate to severe disease (two or more systemic inflammatory response syndrome criteria upon admission) will be prospectively included. Subsequently, participants will be randomised (1:1) to intravenous treatment with either methylnaltrexone or matching placebo (Ringer’s lactate) during 5 days of admission. The primary endpoint will be the group difference in disease severity as defined and measured by the Pancreatitis Activity Scoring System (PASS) score 48 h after randomisation. Secondary endpoints include daily PASS scores; disease severity according to the Atlanta classification; quantification of need for analgesics, nutritional support, intravenous fluid resuscitation and antibiotics; duration of hospital admissions, readmission rates and mortality. Pain intensity and gut function will be self-reported using validated questionnaires. Exploratory endpoints include circulating levels of pro-and anti-inflammatory markers, polyethylene glycol recovery from the urine, circulating levels of blood markers of intestinal permeability, the prevalence of pancreatic complications on computed tomography (CT) scans, and colon transit time assessed using a CT-based radiopaque marker method. DISCUSSION: This trial aims to evaluate the PAMORA methylnaltrexone as a novel targeted pharmacotherapy in patients with moderate to severe AP with the potential benefit of improved patient outcomes. TRIAL REGISTRATION: ClinicalTrials.govNCT04743570. Registered on 28 January 2021. EudraCT 2020-002313-18

The discovery space of ELT-ANDES. Stars and stellar populations

The ArmazoNes high Dispersion Echelle Spectrograph (ANDES) is the optical and near-infrared high-resolution echelle spectrograph envisioned for the European Extremely Large Telescope (ELT). We present a selection of science cases, supported by new calculations and simulations, where ANDES could enable major advances in the fields of stars and stellar populations. We focus on three key areas, including the physics of stellar atmospheres, structure, and evolution; stars of the Milky Way, Local Group, and beyond; and the star-planet connection. The key features of ANDES are its wide wavelength coverage at high spectral resolution and its access to the large collecting area of the ELT. These features position ANDES to address the most compelling and potentially transformative science questions in stellar astrophysics of the decades ahead, including questions which cannot be anticipated today.Comment: 46 pages, 8 figures; submitted to Experimental Astronomy on behalf of the ANDES Science Tea

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

\ua9 2018, The Author(s). Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres

CUBES : the Cassegrain U-band Efficient Spectrograph

In the era of Extremely Large Telescopes, the current generation of 8-10m facilities are likely to remain competitive at ground-UV wavelengths for the foreseeable future. The Cassegrain U-Band Efficient Spectrograph (CUBES) has been designed to provide high-efficiency (> 40%) observations in the near UV (305-400 nm requirement, 300-420 nm goal) at a spectral resolving power of R >20, 000 (with a lower-resolution, sky-limited mode of R ~7, 000). With the design focusing on maximizing the instrument throughput (ensuring a Signal to Noise Ratio (SNR) ~20 per high-resolution element at 313 nm for U ~18.5 mag objects in 1h of observations), it will offer new possibilities in many fields of astrophysics, providing access to key lines of stellar spectra: a tremendous diversity of iron-peak and heavy elements, lighter elements (in particular Beryllium) and light-element molecules (CO, CN, OH), as well as Balmer lines and the Balmer jump (particularly important for young stellar objects). The UV range is also critical in extragalactic studies: the circumgalactic medium of distant galaxies, the contribution of different types of sources to the cosmic UV background, the measurement of H2 and primordial Deuterium in a regime of relatively transparent intergalactic medium, and follow-up of explosive transients. The CUBES project completed a Phase A conceptual design in June 2021 and has now entered the detailed design and construction phase. First science operations are planned for 2028