34 research outputs found
Cytoplasmic location of certain small molecules after their metabolism by the endoplasmic reticulum of rat liver
Get PDFEVIDENCE FOR THE PARTICIPATION OF THE GOLGI APPARATUS IN THE INTRACELLULAR TRANSPORT OF NASCENT ALBUMIN IN THE LIVER CELL
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Send reprint requests to: METABOLISM OF CARBAMAZEPINE AND ITS EPOXIDE METABOLITE IN HUMAN AND RAT LIVER IN VITRO GUNNEL TYBRING, CHRISTER
No full textABSTRACT: The epoxidation of carbamazepine (CBZ) and the hydration of the primary epoxide metabolite was studied in microsomes isolated from ten human livers. To study the epoxide hydrolase activity a high-performance liquid-chromatographic method was developed for the analysis of dlhydro-CBZ-trans-diol. There was a pronounced variation between the specimens in the activity of both enzymes
