Spin-Resolved (e,2e) Coincidences for Heavy Rare-Gas Targets

It has been well established that the Coulomb force alone can produce spin-dependent effects for electron-impact excitation of heavy rare-gas atoms if the incident electrons are spin polarized and the final J state of the atom is resolved. This effect has become known as the fine-structure effect. Here we demonstrate that the same type of effect may be expected for electron-impact ionization

Dynamical (e, 2e) Studies Using Tetrahydrofuran As a DNA Analog

Triple differential cross sections for the electron-impact ionization of the outer valence orbital of tetrahydrofuran have been measured using the (e, 2e) technique. The measurements have been performed with coplanar asymmetric kinematics, at an incident electron energy of 250 eV and at an ejected electron energy of 10 eV, over a range of momentum transfers. The experimental results are compared with theoretical calculations carried out using the molecular three-body distorted wave model. The results obtained are important for gaining an understanding of electron driven processes at a molecular level and for modeling energy deposition in living tissue

Spin Polarisation and Scattering Asymmetry for Electron Impact Excitation of the (6s6p) States of Mercury: DWBA Treatment

Distorted-wave Born approximation results for the spin polarisation and the scattering asymmetry for electron impact excitation of the (6s6p) 1P1 and (6s6p) 3P0,1,2 states of mercury are presented and compared with presently available experimental data. The sensitivity of the results to the atomic wavefunctions and to the relativistic approximation is examined. The predictions of the \u27fine-structure effect\u27 are investigated and results for single magnetic sublevels are given

Spin-resolved triple differential cross sections of xenon

Spin-resolved triple differential (e, 2e) cross sections have been measured for ionization of xenon atoms by polarized electrons for energies between 40 and 200 eV. Significant spin up-down asymmetries in the (e, 2e) cross sections have been obtained at all energies. These are dominated by the interplay of orbital orientation, fine-structure interaction and exchange of the colliding electrons (\u27fine-structure effect\u27), whereas the influence of relativistic orbitals and of the continuum spin-orbit interaction is less important. The results are compared with recent DWBA calculations that include exchange with the electrons of the residual ion (exchange distortion), and satisfactory agreement is found. In particular, the discrepancies between theory and experiment at 40 eV and symmetric energy sharing are resolved

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Background: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics. Methods: A genetic risk score incorporating genetic association data for IA and 17 traits related to IA (so-called metaGRS) was created using 1161 IA cases and 407 392 controls from the UK Biobank population study. The metaGRS was validated in combination with risk factors blood pressure, sex, and smoking in 828 IA cases and 68 568 controls from the Nordic HUNT population study. Furthermore, we assessed association between the metaGRS and patient characteristics in a cohort of 5560 IA patients. Results: Per SD increase of metaGRS, the hazard ratio for ASAH incidence was 1.34 (95% CI, 1.20-1.51) and the odds ratio for IA presence 1.09 (95% CI, 1.01-1.18). Upon including the metaGRS on top of clinical risk factors, the concordance index to predict ASAH hazard increased from 0.63 (95% CI, 0.59-0.67) to 0.65 (95% CI, 0.62-0.69), while prediction of IA presence did not improve. The metaGRS was statistically significantly associated with age at ASAH (β=-4.82×10-3per year [95% CI, -6.49×10-3to -3.14×10-3]; P=1.82×10-8), and location of IA at the internal carotid artery (odds ratio=0.92 [95% CI, 0.86-0.98]; P=0.0041). Conclusions: The metaGRS was predictive of ASAH incidence, although with limited added value over clinical risk factors. The metaGRS was not predictive of IA presence. Therefore, we do not recommend using this metaGRS in daily clinical care. Genetic risk does partly explain the clinical heterogeneity of IA warranting prioritization of clinical heterogeneity in future genetic prediction studies of IA and ASAH