2,005 research outputs found
Ghost of invasion past: legacy effects on community disassembly following eradication of an invasive ecosystem engineer
By changing ecosystem processes and altering the physical landscape, invasive ecosystem engineers can have substantial impacts on ecosystem functions and human economies and may facilitate other non-native species. Eradication programs in terrestrial and aquatic systems aim to reverse the impacts of invasive species and return the system to its pre-invasion conditions. Despite an extensive focus on the impacts of both native and non-native ecosystem engineers, the consequences of removing invasive ecosystem engineers, particularly in coastal ecosystems, are largely unknown. In this study, we quantified changes in a benthic community following the eradication of the invasive ecosystem engineer, hybrid cordgrass Spartina, in San Francisco Bay, California. We used field experimental manipulations to test for persistent effects of both aboveground and belowground structural modifications of the invasive plant on the benthic community. We found significant effects of the invasive plant more than four years following eradication. Experimental modification of the above- vs. belowground structure of this ecosystem engineer revealed taxonomic specific effects resulting in hysteresis in the recovery of the benthic food webs. We found that these legacy effects resulted from two specific mechanisms: (1) delayed breakdown of belowground structures (stems, roots) and (2) persistence of other invasive species whose invasion was facilitated by the ecosystem engineer. Both of these mechanisms are likely to occur in similar systems where belowground structures breakdown more slowly or where other associated long-lived invaders persist. Our work is among the first to quantify the slow rate of change in food web and community processes and the persistent legacy effects of an invasive ecosystem engineer in a coastal ecosystem. We suggest that this delayed transition to pre-invasion conditions could resemble an alternate state that would be misidentified without a sufficient monitoring interval or recovery duration, with consequences for future management and restoration activity planning
Model-based diagnosis of acute pulmonary embolism - results from a porcine model
peer reviewe
HCI as a means to prosociality in the economy
HCI research often involves intervening in the economic lives of people, but researchers only rarely give explicit consideration to what actually constitutes prosociality in the economy. Much has been said previously regarding sustainability but this has largely focused on environmental rather than interpersonal relations. This paper provides an analysis of how prosocial HCI has been discussed and continues to be defined as a research field. Based on a corpus of published works, we describe a variety of genres of work relating to prosocial HCI. Key intellectual differences are explored, including the epistemological and ethical positions involved in designing for prosocial outcomes as well as how HCI researchers posit economic decision-making. Finally, emerging issues and opportunities for further debate and collaboration are discussed in turn
Pecunia non olet but does rose money smell?: on rose oil prices and moral economy in Isparta, Turkey
Model for eukaryotic tail-anchored protein binding based on the structure of Get3
The Get3 ATPase directs the delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). TA-proteins are characterized by having a single transmembrane helix (TM) at their extreme C terminus and include many essential proteins, such as SNAREs, apoptosis factors, and protein translocation components. These proteins cannot follow the SRP-dependent co-translational pathway that typifies most integral membrane proteins; instead, post-translationally, these proteins are recognized and bound by Get3 then delivered to the ER in the ATP dependent Get pathway. To elucidate a molecular mechanism for TA protein binding by Get3 we have determined three crystal structures in apo and ADP forms from Saccharomyces cerevisae (ScGet3-apo) and Aspergillus fumigatus (AfGet3-apo and AfGet3-ADP). Using structural information, we generated mutants to confirm important interfaces and essential residues. These results point to a model of how Get3 couples ATP hydrolysis to the binding and release of TA-proteins
Degradative inactivation of the peroxisomal enzyme, alcohol oxidase, during adaptation of methanol-grown Candida boidinii to ethanol
Computational modelling and experimental tank testing of the multi float WaveSub under regular wave forcing
A submerged wave device generates energy from the relative motion of floating bodies. In 1 WaveSub, three floats are joined to a reactor; each connected to a spring and generator. Electricity generated 2 damps the orbital movements of the floats. The forces are non-linear and each float interacts with the others. 3 Tuning to the wave climate is achieved by changing the line lengths so there is a need to understand the 4 performance trade-offs for a large number of configurations. This requires an efficient, large displacement, 5 multidirectional, multi-body numerical scheme. Results from a 1/25 scale wave basin experiment are described. 6 Here we show that a time domain linear potential flow formulation (Nemoh, WEC-Sim) can match the tank 7 testing provided that suitably tuned drag coefficients are employed. Inviscid linear potential models can match 8 some wave device experiments, however, additional viscous terms generally provide better accuracy. Scale 9 experiments are also prone to mechanical friction and we estimate friction terms to improve the correlation 10 further. The resulting error in mean power between numerical and physical models is approximately 10%. 11 Predicted device movement shows a good match. Overall, drag terms in time domain wave energy modelling 12 will improve simulation accuracy in wave renewable energy device design
Development of a model-based clinical sepsis biomarker for critically ill patients
Invited.
online 15 May 2010.Sepsis occurs frequently in the intensive care unit (ICU) and is a leading cause of admission,
mortality, and cost. Treatment guidelines recommend early intervention, however positive
blood culture results may take up to 48 h. Insulin sensitivity (SI) is known to decrease
with worsening condition and could thus be used to aid diagnosis. Some glycemic control
protocols are able to accurately identify insulin sensitivity in real-time.
Hourly model-based insulin sensitivity SI values were calculated from glycemic control
data of 36 patients with sepsis. The hourly SI is compared to the hourly sepsis score (ss)
for these patients (ss = 0–4 for increasing severity). A multivariate clinical biomarker was
also developed to maximize the discrimination between different ss groups. Receiver operator
characteristic (ROC) curves for severe sepsis (ss=2) are created for both SI and the
multivariate clinical biomarker.
Insulin sensitivity as a sepsis biomarker for diagnosis of severe sepsis achieves a 50%
sensitivity, 76% specificity, 4.8% positive predictive value (PPV), and 98.3% negative predictive
value (NPV) at an SI cut-off value of 0.00013 L/mU/min. Multivariate clinical biomarker
combining SI, temperature, heart rate, respiratory rate, blood pressure, and their respective
hourly rates of change achieves 73% sensitivity, 80% specificity, 8.4% PPV, and 99.2% NPV.
Thus, themultivariate clinical biomarker provides an effective real-time negative predictive
diagnostic for severe sepsis. Examination of both inter- and intra-patient statistical distribution
of this biomarker and sepsis score shows potential avenues to improve the positive
predictive value
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