The Impact of Leadership Training on the Development of Selected Nebraska Communities

Securing of appropriate resources is a vital activity for communities if they are to exist and grow in contemporary society. The increase in the size, scope, and complexity of municipal services has sometimes outpaced municipalities\u27 capacities to manage those services. The ability of local leaders to manage a community\u27s resources efficiently and effectively has been one of the central issues underlying community development trends throughout the past decade. New demands on local decision makers require innovative strategies to improve managerial skills among the cities\u27 core leadership

The Impact of Rural Nebraska Industrial Development on the Migration of Rural Youth

For more than a century Americans have migrated from the rural communities in which they were raised, but by 1970 this process had begun to change. Nebraska, however, has not reflected this change, and Nebraskans have continued to leave non-metropolitan areas in large numbers. By 1976 the State stood alone among seven central and southern plains states in having non-metropolitan population losses (Miller, 1978)

Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome

Although systems biology is a perfect framework for investigating system-level declines during aging, only a few reports have focused on a comprehensive understanding of system-level changes in the context of aging systems. The present study aimed to understand the most sensitive biological systems affected during aging and to reveal the systems underlying the crosstalk between aging and the ability of calorie restriction (CR) to effectively slow-down aging. We collected and analyzed 478 aging- and 586 CR-related mouse genes. For the given genes, the biological systems that are significantly related to aging and CR were examined according to three aspects. First, a global characterization by Gene Ontology (GO) was performed, where we found that the transcriptome (a set of genes) for both aging and CR were strongly related in the immune response, lipid metabolism, and cell adhesion functions. Second, the transcriptional modularity found in aging and CR was evaluated by identifying possible functional modules, sets of genes that show consistent expression patterns. Our analyses using the given functional modules, revealed systemic interactions among various biological processes, as exemplified by the negative relation shown between lipid metabolism and the immune response at the system level. Third, transcriptional regulatory systems were predicted for both the aging and CR transcriptomes. Here, we suggest a systems biology framework to further understand the most important systems as they age