10 research outputs found

    Présence au Maroc de la race 2 de Plasmopara halstedii, agent du mildiou du tournesol

    No full text
    Des tests de laboratoire réalisés sur des isolats marocains de mildiou ont mis en évidence l'existence, en plus de la race 1 dite race «Européenne», d'une race plus virulente qui a le même comportement que la race 2 américaine.Plasmopara halstedii race 2 of downy mildew is present on sunflower in Morocco. The reaction of five different Plasmopara halstedii isolates has been analysed on a range of differential genotypes. Four isolates had a similar reaction to race 1 (the European race). However one isolate had the ability to infect genotypes with no gene of resistance and also the line Rha 266 (PI1) which is resistant to race 1. The reaction of this isolate was similar to that of the American race 2. This is the first record of this race in Morocco

    Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor.

    No full text
    Glucose-dependent insulinotropic polypeptide (GIP) is a hormone secreted by the endocrine K-cells from the duodenum that stimulates glucose-induced insulin secretion. Here, we present the molecular characterization of the human pancreatic islet GIP receptor. cDNA clones for the GIP receptor were isolated from a human pancreatic islet cDNA library. They encoded two different forms of the receptor, which differed by a 27-amino acid insertion in the COOH-terminal cytoplasmic tail. The receptor protein sequence was 81% identical to that of the rat GIP receptor. When expressed in Chinese hamster lung fibroblasts, both forms of the receptor displayed high-affinity binding for GIP (180 and 600 pmol/l). GIP binding was displaced by < 20% by 1 mumol/l glucagon, glucagon-like peptide (GLP-I)(7-36) amide, vasoactive intestinal peptide, and secretin. However exendin-4 and exendin-(9-39) at 1 mumol/l displaced binding by approximately 70 and approximately 100% at 10 mumol/l. GIP binding to both forms of the receptor induced a dose-dependent increase in intracellular cAMP levels (EC50 values of 0.6-0.8 nmol/l) but no elevation of cytoplasmic calcium concentrations. Interestingly, both exendin-4 and exendin-(9-39) were antagonists of the receptor, inhibiting GIP-induced cAMP formation by up to 60% when present at a concentration of 10 mumol/l. Finally, the physical and genetic chromosomal localization of the receptor gene was determined to be on 19q13.3, close to the ApoC2 gene. These data will help study the physiology and pathophysiology of the human GIP receptor

    Présence au Maroc de la race 2 de Plasmopara halstedii, agent du mildiou du tournesol

    No full text
    Des tests de laboratoire réalisés sur des isolats marocains de mildiou ont mis en évidence l'existence, en plus de la race 1 dite race «Européenne», d'une race plus virulente qui a le même comportement que la race 2 américaine.Plasmopara halstedii race 2 of downy mildew is present on sunflower in Morocco. The reaction of five different Plasmopara halstedii isolates has been analysed on a range of differential genotypes. Four isolates had a similar reaction to race 1 (the European race). However one isolate had the ability to infect genotypes with no gene of resistance and also the line Rha 266 (PI1) which is resistant to race 1. The reaction of this isolate was similar to that of the American race 2. This is the first record of this race in Morocco

    The Importance of Precision Medicine in Type 2 Diabetes Mellitus (T2DM): From Pharmacogenetic and Pharmacoepigenetic Aspects

    No full text
    corecore