Metal-free restorations: esthetic considerations, treatment planning, preparation, manufacturing, luting, and followup

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Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration.

The 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high prevalence of AD, with a strategic focus on advancing research, treatment, and management to meet the evolving challenges in the field. This multidisciplinary forum brought together top leaders from research, clinical practice, policy, and patient advocacy to discuss the critical aspects of AD, including neuroimmunology, environmental factors, comorbidities, and breakthroughs in prevention, diagnosis, and treatment. The discussions were geared towards fostering a collaborative approach to integrate these advancements into practical, patient-centric care. The forum underlined the mounting burden of AD, attributing it to significant environmental and lifestyle changes. It acknowledged the progress in understanding AD and in developing targeted therapies but recognized a gap in translating these innovations into clinical practice. Emphasis was placed on the need for enhanced awareness, education, and stakeholder engagement to address this gap effectively and to consider environmental and lifestyle factors in a comprehensive disease management strategy. The 4th Davos Declaration marks a significant milestone in the journey to improve care for people with AD. By promoting a holistic approach that combines research, education, and clinical application, the Forum sets a roadmap for stakeholders to collaborate to improve patient outcomes in AD, reflecting a commitment to adapt and respond to the dynamic challenges of AD in a changing world

Solution Focused Approach and Usage of Nursing

"Problem talk creates problems; solution talk creates solutions " Steve de Shazer In recent years, concern for solution-oriented approach has increased in nursing practice. In this review it is aimed to give information about nursing application of solution-oriented approach whose efficacy has been proved with many studies. In addition, solution-oriented approach is what how it turned out, the answer to the question of principle, and that is what the management strategy and what the nursing relationship will be sought. [JCBPR 2016; 5(3.000): 145-152

Topical Pimecrolimus 1% Cream for Resistant Seborrheic Dermatitis of the Face An Open-Label Study

WOS: 000273847700006PubMed: 20000875Background: Treatment options for seborrheic dermatitis are numerous, including both topical and systemic agents (e.g. topical corticosteroids, oral antifungals, and psoralen plus UVA). However, long-term use of topical corticosteroids may lead to adverse effects. Pimecrolimus 1% cream is an effective and well tolerated treatment for seborrheic dermatitis. Objective: To explore the efficacy of pimecrolimus 1% cream for the treatment of seborrheic dermatitis lesions resistant to conventional treatments. Methods: Sixteen patients with resistant seborrheic dermatitis of the face applied pimecrolimus 1% cream twice daily for 2 weeks. The lesions were assessed clinically and the severity of the signs were assessed using a 4-point score. Additionally, the scores of all affected regions (paranasal, forehead, and eyebrows) were evaluated separately to assess whether different results would be obtained in different regions of the face. Also, patients completed self-assessments on a 100 mm Visual Analogue Scale (VAS) at each visit. Results: Statistically significant reductions in the scores of all parameters were observed at day 7 and day 14 of the study. There were no significant differences between the responses on the three regions of the face. No adverse effects were reported except for temporary pruritus immediately after the application of pimecrolimus 1% cream in one patient. Conclusion: Although the interpretation of efficacy was limited by the open-label, non-controlled study design and the small number of patients, this trial suggests that pimecrolimus 1% cream may be a successful treatment choice for patients with resistant seborrheic dermatitis of the face

Metal-Free Restorations: Esthetic Considerations, Treatment Planning, Preparation, Manufacturing, Luting, and Followup

WOS: 000367238300001PubMed ID: 2679371

Using nanogap in label-free impedance based electrical biosensors to overcome electrical double layer effect

Guler, Mustafa/0000-0003-1168-202X; Acar, Handan/0000-0001-8708-9279WOS: 000397499300008Point-of-care biosensor applications require low-cost and low-power solutions. They offer being easily accessible at home site. They are usable without any complex sample handling or any kind of special expertise. Impedance spectroscopy has been utilized for point-of-care biosensor applications; however, electrical double layer formed due to ions in the solution of interest has been a challenge, due to shielding of the electric field used for sensing the target molecules. Here in this study, we demonstrate a nanogap based biosensor structure with a relatively low frequency (1-100 kHz) measurement technique, which not only eliminates the undesired shielding effect of electrical double layer but also helps in minimizing the measurement volume and enabling low concentration (A mu molar level) detection of target molecules (streptavidin). Repeatability and sensitivity tests proved stable and reliable operation of the sensors. These biosensors might offer attributes such as low-cost label-free detection, fast measurement and monolithic chip integrability.European Union Framework Program 7 Marie Curie IRG [239444, 249196]; COST NanoTPEuropean Cooperation in Science and Technology (COST); TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109E044, 112M004, 112E052, 112M944, 113M815]; TUBITAK-BIDEBTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)This work was supported in part by European Union Framework Program 7 Marie Curie IRG Grant 239444 and 249196, COST NanoTP, TUBITAK Grants 109E044, 112M004, 112E052, 112M944 and 113M815. The authors acknowledge support from TUBITAK-BIDEB. The authors thank Firat Yilmaz for his contributions and Dr. Mohammad Ghaffari for SEM images