Inclusion of seasonal variation in river system microbial communities and phototroph activity increases environmental relevance of laboratory chemical persistence tests

Regulatory tests assess crop protection product environmental fate and toxicity before approval for commercial use. Although globally applied laboratory tests can assess biodegradation, they lack environmental complexity. Microbial communities are subject to temporal and spatial variation, but there is little consideration of these microbial dynamics in the laboratory. Here, we investigated seasonal variation in the microbial composition of water and sediment from a UK river across a two-year time course and determined its effect on the outcome of water-sediment (OECD 308) and water-only (OECD 309) biodegradation tests, using the fungicide isopyrazam. These OECD tests are performed under dark conditions, so test systems incubated under non-UV light:dark cycles were also included to determine the impact on both inoculum characteristics and biodegradation. Isopyrazam degradation was faster when incubated under non-UV light at all collection times in water-sediment microcosms, suggesting that phototrophic communities can metabolise isopyrazam throughout the year. Degradation rate varied seasonally between inoculum collection times only in microcosms incubated in the light, but isopyrazam mineralisation to 14CO2 varied seasonally under both light and dark conditions, suggesting that heterotrophic communities may also play a role in degradation. Bacterial and phototroph communities varied across time, but there was no clear link between water or sediment microbial composition and variation in degradation rate. During the test period, inoculum microbial community composition changed, particularly in non-UV light incubated microcosms. Overall, we show that regulatory test outcome is not influenced by temporal variation in microbial community structure; however, biodegradation rates from higher tier studies with improved environmental realism, e.g. through addition of non-UV light, may be more variable. These data suggest that standardised OECD tests can provide a conservative estimate of pesticide persistence end points and that additional tests including non-UV light could help bridge the gap between standard tests and field studies

Exciting dark matter in the galactic center

We reconsider the proposal of excited dark matter (DM) as an explanation for excess 511 keV gamma rays from positrons in the galactic center. We quantitatively compute the cross section for DM annihilation to nearby excited states, mediated by exchange of a new light gauge boson with off-diagonal couplings to the DM states. In models where both excited states must be heavy enough to decay into e^+ e^- and the ground state, the predicted rate of positron production is never large enough to agree with observations, unless one makes extreme assumptions about the local circular velocity in the Milky Way, or alternatively if there exists a metastable population of DM states which can be excited through a mass gap of less than 650 keV, before decaying into electrons and positrons.Comment: Dedicated to the memory of Lev Kofman; 16 pages, 9 figures; v3 added refs, minor changes, accepted to PR

The Parameterized Post-Friedmann Framework for Theories of Modified Gravity: Concepts, Formalism and Examples

A unified framework for theories of modified gravity will be an essential tool for interpreting the forthcoming deluge of cosmological data. We present such a formalism, the Parameterized Post-Friedmann framework (PPF), which parameterizes the cosmological perturbation theory of a wide variety of modified gravity models. PPF is able to handle spin-0 degrees of freedom from new scalar, vector and tensor fields, meaning that it is not restricted to simple models based solely on cosmological scalar fields. A direct correspondence is maintained between the parameterization and the underlying space of theories, which allows us to build up a `dictionary' of modified gravity theories and their PPF correspondences. In this paper we describe the construction of the parameterization and demonstrate its use through a number of worked examples relevant to the current literature. We indicate how the formalism will be implemented numerically, so that the dictionary of modified gravity can be pitted against forthcoming observations.Comment: 24 pages, updated to match version published in PRD. Discussion of section 4 extended. Suggestions for the busy reader are given at the end of section

Nonlinear dynamics of two coupled nano-electromechanical resonators

As a model of coupled nano-electromechanical resonantors we study two nonlinear driven oscillators with an arbitrary coupling strength between them. Analytical expressions are derived for the oscillation amplitudes as a function of the driving frequency and for the energy transfer rate between the two oscillators. The nonlinear restoring forces induce the expected nonlinear resonance structures in the amplitude-frequency characteristics with asymmetric resonance peaks. The corresponding multistable behavior is shown to be an efficient tool to control the energy transfer arising from the sensitive response to small changes in the driving frequency. Our results imply that the nonlinear response can be exploited to design precise sensors for mass or force detection experiments based on nano-electromechanical resonators.Comment: 19 pages, 2 figure

Sixth-Order Vacuum-Polarization Contribution to the Lamb Shift of the Muonic Hydrogen

The sixth-order electron-loop vacuum-polarization contribution to the $2P_{1/2} - 2S_{1/2}$ Lamb shift of the muonic hydrogen ($\mu^{-} p^+$ bound state) has been evaluated numerically. Our result is 0.007608(1) meV. This eliminates the largest uncertainty in the theoretical calculation. Combined with the proposed precision measurement of the Lamb shift it will lead to a very precise determination of the proton charge radius.Comment: 4 pages, 5 figures the totoal LS number is change

On the combination of omics data for prediction of binary outcomes

Enrichment of predictive models with new biomolecular markers is an important task in high-dimensional omic applications. Increasingly, clinical studies include several sets of such omics markers available for each patient, measuring different levels of biological variation. As a result, one of the main challenges in predictive research is the integration of different sources of omic biomarkers for the prediction of health traits. We review several approaches for the combination of omic markers in the context of binary outcome prediction, all based on double cross-validation and regularized regression models. We evaluate their performance in terms of calibration and discrimination and we compare their performance with respect to single-omic source predictions. We illustrate the methods through the analysis of two real datasets. On the one hand, we consider the combination of two fractions of proteomic mass spectrometry for the calibration of a diagnostic rule for the detection of early-stage breast cancer. On the other hand, we consider transcriptomics and metabolomics as predictors of obesity using data from the Dietary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome (DILGOM) study, a population-based cohort, from Finland

On the regularization scheme and gauge choice ambiguities in topologically massive gauge theories

It is demonstrated that in the (2+1)-dimensional topologically massive gauge theories an agreement of the Pauli-Villars regularization scheme with the other schemes can be achieved by employing pairs of auxiliary fermions with the opposite sign masses. This approach does not introduce additional violation of discrete (P and T) symmetries. Although it breaks the local gauge symmetry only in the regulator fields' sector, its trace disappears completely after removing the regularization as a result of superrenormalizability of the model. It is shown also that analogous extension of the Pauli-Villars regularization in the vector particle sector can be used to agree the arbitrary covariant gauge results with the Landau ones. The source of ambiguities in the covariant gauges is studied in detail. It is demonstrated that in gauges that are softer in the infrared region (e.g. Coulomb or axial) nonphysical ambiguities inherent to the covariant gauges do not arise.Comment: Latex, 13 pages. Replaced mainly to change preprint references to journal one

A 4 Ga record of granitic heat production: Implications for geodynamic evolution and crustal composition of the early Earth

The radiogenic heat produced by granites has a significant influence on the thermal state of the crust due to both their relatively high heat production with respect to most rock types and high abundance. However, the variations in present day heat production with age are generally based on relatively few measurements that are poorly distributed geographically. In this study, we construct a global model for the heat production of granitic rocks for the past 4 Ga using 13,400 geochemical analyses. We observe a nearly monotonic increase in radiogenic heat production from 4.0 to 2.0 Ga, which mirrors a shift from more TTG-like calcic to more alkalic compositions. This shift towards high-heat-producing granites post-2.0 Ga is often attributed to enrichment related to reworking and/or erosion. However, there is a strong correlation between granitic heat production with that of similarly-aged basalts and gabbros, which suggests a dominant mantle-level component to granite generation rather than crustal reworking. Secular cooling and mantle depletion may affect heat production, but the signal is complex and cannot easily explain the heat production with age profile. The most likely mechanism to describe the observed heat production–age pattern is one of selective preservation as a consequence of thermal stability. High heat producing terranes that were not stable during the Archean become increasingly stable towards the present. This selective preservation model has significant implications for the growth and composition of the continental crust. Ferroan, alkalic and felsic compositions were less thermally stable in the Archean due to their generally higher heat production and thus may have been more common in the early Earth than assumed by most compositional models. The temporal heat production model determined in this study can be used to improve geotherm models, particularly within ancient terranes.D.Hasterok, M.Gard, G.Cox, M.Han

What are the Best Hierarchical Descriptors for Complex Networks?

This work reviews several hierarchical measurements of the topology of complex networks and then applies feature selection concepts and methods in order to quantify the relative importance of each measurement with respect to the discrimination between four representative theoretical network models, namely Erd\"{o}s-R\'enyi, Barab\'asi-Albert, Watts-Strogatz as well as a geographical type of network. The obtained results confirmed that the four models can be well-separated by using a combination of measurements. In addition, the relative contribution of each considered feature for the overall discrimination of the models was quantified in terms of the respective weights in the canonical projection into two dimensions, with the traditional clustering coefficient, hierarchical clustering coefficient and neighborhood clustering coefficient resulting particularly effective. Interestingly, the average shortest path length and hierarchical node degrees contributed little for the separation of the four network models.Comment: 9 pages, 4 figure

The Distribution of Constituent Charm Quarks in the Hadron

Using a statistical approach in the framework of non-covariant perturbation theory the distributions for light and charmed quarks in the hadron have been derived, taking into account the mass of the charmed quark. The parameters of the model have been extracted from the comparison with NA3 data on hadroproduction of J/psi particles. A reanalysis of the EMC data on charm production in muon-nucleon scattering has been performed. It has been found in comparison with the conventional source of charmed quarks from photon-gluon fusion, that the EMC data indicate the presence of an additional contribution from deep-inelastic scattering on charmed quarks at large x. The resulting admixture of the Fock states, containing charmed quarks in the decomposition of the proton wave function is of the order of 1%. The approach presented for the excitation of the Fock states with charmed quarks can also be applied to states with beauty quarks as well as to the hadronic component of the virtual photon (resolved photon component).Comment: 23 pages, 4 PostScript figures, Latex2e. In revised version in comparison with the original one all (?) mistypings have been corrected, one more thank has been added and the comparison of the pion and the proton J/psi production is described in more detai