Student Perceptions of Team-Based Learning in an Advanced Inorganic Chemistry Course

Team-based learning (TBL) has been gaining increasing attention in chemistry teaching, although it remains relatively under-exploited, especially compared to management and medical sciences. This study explores student perceptions of team-based learning as an active learning technique in an advanced inorganic chemistry topic. It focuses on qualitative research methods using thematic analysis of data collected through questionnaires and a focus group. Students were found to strongly associate TBL with being an effective active learning experience, where interaction with the pre-class preparatory materials is incentivized by the accountability they feel to their team members. The highly structured nature of TBL, where learning, assessment, and clarification of the core concepts takes place before more challenging problem solving, was highlighted, alongside the importance of the instructor in the TBL process. The importance of interactivity in the pre-class materials and alignment of the TBL materials with the end of course assessment was also emphasized. Students are hugely positive about TBL as being effective for the learning of challenging problem-solving topics, but are reticent to acknowledge that the flipped classroom model can be more effective than lectures

Negotiating stance within discourses of class: reactions to Benefits Street

In this article, we examine the way that audiences respond to particular representations of poverty. Using clips from the Channel 4 television programme Benefits Street we conducted focus groups in four locations across the UK, working with people from different socioeconomic backgrounds who had different experiences with the benefits system. Benefits Street (2014) is an example of reality television where members of the public are followed by film crews as they perform everyday tasks and routines. Our choice to focus on this particular programme was prompted by the huge media response that it received when it was broadcast; Benefits Street generated 950 complaints to regulatory watchdog Ofcom (2014) and was referred to as ‘poverty porn’ (Clark, 2014). We focus on the way that viewers of this programme produce assessments of those on benefits, analysing the discursive strategies used by our participants when evaluating representations of those on benefits. Specifically, we consider how the participants in our study construct their own stance and attribute stance to others through naming and agency practices, the negotiation of opinion, and stake inoculation. We invited our participants to judge the people they saw on screen, but they went beyond this. They used clips of the programme as stimuli to collaboratively construct an overarchingly-negative stereotype of those on benefits. We conclude that Benefits Street is not just an entertainment programme, but is rather a site for ideological construction and the perpetuation of existing stereotypes about benefit claimants. The programme (and others like it) invites negative evaluations of those on benefits and is thus a worthy site for critical linguistic analysis

Pneumococcal Colonisation Rates in Patients Admitted to a UK Hospital with Lower Respiratory Tract Infection - a prospective case-control study

BACKGROUND Current diagnostic tests are ineffective at identifying the aetiological pathogen in hospitalised adults with lower respiratory tract infection (LRTI). The association of pneumococcal colonisation with disease has been suggested as a means to increase diagnostic precision. We compared pneumococcal colonisation rate and density of nasal pneumococcal colonisation by a) classical culture and b) quantitative real time lytA Polymerase Chain Reaction (qPCR) in patients admitted to hospital in the UK with LRTI compared to control patients. METHODS 826 patients were screened for inclusion in this prospective case-control study. 38 patients were recruited, 19 with confirmed LRTI and 19 controls with another diagnosis. Nasal wash (NW) was collected at the time of recruitment. RESULTS Pneumococcal colonisation was detected in 1 LRTI patient and 3 controls (p=0.6) by classical culture. Using qPCR pneumococcal colonisation was detected in 10 LRTI patients and 8 controls (p=0.5). Antibiotic usage prior to sampling was significantly higher in the LRTI than control group 19 v. 3 (p8000 copies/ml on qPCR pneumococcal colonisation was found in 3 LRTI patients and 4 controls (p > 0.05). CONCLUSIONS We conclude that neither prevalence nor density of nasal pneumococcal colonisation (by culture and qPCR) can be used as a method of microbiological diagnosis in hospitalised adults with LRTI in the UK. A community based study recruiting patients prior to antibiotic therapy may be a useful future step

OH detection by absorption of frequency-doubled diode laser radiation at 308nm

Radiation at 308 nm has been obtained by frequency doubling the output of a commercial diode laser cooled to 165 K. A single pass through a crystal of LiIO3 converted 1 mW of 616 nm radiation to 50 pW of UV, and this was used to detect the OH radical in absorption in a flow tube. Possible extensions of the method for detection of OH in the atmosphere are discussed

Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism

Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation. NRas signals downstream of the major melanocyte tyrosine kinase receptor c-kit and activated NRas results in increased signaling via the extracellular signal–regulated kinase (ERK)/MAPK/ERK kinase/mitogen-activated protein kinase (MAPK) pathways to enhance proliferation. The Ras oncogene also activates signaling via the related Rho GTPase Rac1, which can mediate growth, survival, and motility signaling. We tested the effects of activated NRasQ61K on the proliferation, motility, and invasiveness of melanoblasts and melanocytes in the developing mouse and ex vivo explant culture as well as in a melanoma transplant model. We find an important role for Rac1 downstream of NRasQ61K in mediating dermal melanocyte survival in vivo in mouse, but surprisingly NRasQ61K does not appear to affect melanoblast motility or proliferation during mouse embryogenesis. We also show that genetic deletion or pharmacological inhibition of Rac1 in NRasQ61K induced melanoma suppresses tumor growth, lymph node spread, and tumor cell invasiveness, suggesting a potential value for Rac1 as a therapeutic target for activated NRas-driven tumor growth and invasiveness

Caverns: Kentucky Middle School Poetry (Volume 1, 2018)

The editors of CAVERNS: Kentucky Middle School Poetry, volume 1, 2018, are extremely grateful to the talented students, dedicated teachers, and proud parents who made this first volume possible. Poems were solicited from classroom teachers during National Poetry Month, April 2017. The poems were selected for publication after extensive editorial board review, using a rubric adapted from Christine Lewy (2001). Only poems with signed parental/guardian permission letters were published. Students or parents decided whether to publish the poet’s full name or first name and last initial only. The poems were divided roughly into sections by topic: start-and-stop poems, homage, haiku, reflections, and ruminations. Future editions may have different sections. Support for the 2018 edition of CAVERNS: Kentucky Middle School Poetry was provided by the Kentucky Reading Association (KRA) and the Western Kentucky Reading Council of KRA

Cognitive impairment, fatigue and depression in multiple sclerosis: Is there a difference between benign and non-benign MS?

INTRODUCTION Multiple Sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system (CNS). The severity of disability in people with MS (PwMS) is generally measured with the Expanded Disability Status Scale (EDSS). A variant of MS known as 'benign MS' (BMS) has been defined as an EDSS score of 3 or lower, combined with a disease duration of 10 years or longer; however, there is disagreement in the field about whether BMS really exists. Given that the EDSS does not capture cognitive issues, communication dysfunction, fatigue, depression, or anxiety properly, its ability to accurately represent disability in all PwMS, including BMS, remains questionable. METHODS In this study, 141 persons with BMS (PwBMS) were included, consisting of 115 females (82%) and 26 males (18%) with a mean age of 50.8 (±8.68). A computerized test battery (NeuroTrax®) was used to assess cognition, covering seven cognitive domains (memory, executive function, visual-spatial processing, verbal function, attention, information processing, and motor skills). Fatigue was measured using the Fatigue Severity Scale (FSS). The Beck Depression Inventory (BDI) was used to assess symptoms of depression. Cognitive impairment was defined for this study as when someone has a score lower than 85 in at least two subdomains of the cognitive test battery. Rates of impairment were compared to 158 persons with non-benign MS (PwNBMS; with a disease duration of 10 years and longer and an EDSS score higher than 3) and 487 PwMS with a disease duration of fewer than 10 years. RESULTS Cognitive impairment was found in 38% of PwBMS and in 66% of PwNBMS (p<0.001). In PwBMS, the lowest rate of impairment was found in the verbal function domain (18%) and the highest rate of impairment in the domain of information processing (32%). Fatigue and depression were found in 78% and 55% of all PwBMS, with no difference in these rates between PwBMS and PwNBMS (p = 0.787 and p = 0.316 resp.) CONCLUSION: Cognitive impairment, fatigue and depression are common among people with an EDSS-based definition of benign MS. These aspects should be incorporated into a new and better definition of truly benign MS

Restoring shellfish reefs: Global guidelines for practitioners and scientists

Widespread global declines in shellfish reefs (ecosystem-forming bivalves such as oysters and mussels) have led to growing interest in their restoration and protection. With restoration projects now occurring on four continents and in at least seven countries, global restoration guidelines for these ecosystems have been developed based on experience over the past two decades. The following key elements of the guidelines are outlined: (a) the case for shellfish reef resto- ration and securing financial resources; (b) planning, feasibility, and goal set- ting; (c) biosecurity and permitting; (d) restoration in practice; (e) scaling up from pilot to larger scale restoration, (f) monitoring, (g) restoration beyond oyster reefs (specifically mussels), and (h) successful communication for shell- fish reef restoration projects

EVLA Observations Constrain the Environment and Progenitor System of Type Ia Supernova 2011fe

We report unique EVLA observations of SN 2011fe representing the most sensitive radio study of a Type Ia supernova to date. Our data place direct constraints on the density of the surrounding medium at radii ~10^15-10^16 cm, implying an upper limit on the mass loss rate from the progenitor system of Mdot <~ 6 x 10^-10 Msol/yr (assuming a wind speed of 100 km/s), or expansion into a uniform medium with density n_CSM <~ 6 cm^-3. Drawing from the observed properties of non-conservative mass transfer among accreting white dwarfs, we use these limits on the density of the immediate environs to exclude a phase space of possible progenitors systems for SN 2011fe. We rule out a symbiotic progenitor system and also a system characterized by high accretion rate onto the white dwarf that is expected to give rise to optically-thick accretion winds. Assuming that a small fraction, 1%, of the mass accreted is lost from the progenitor system, we also eliminate much of the potential progenitor parameter space for white dwarfs hosting recurrent novae or undergoing stable nuclear burning. Therefore, we rule out the most popular single degenerate progenitor models for SN 2011fe, leaving a limited phase space inhabited by some double degenerate systems and exotic progenitor scenarios.Comment: Accepted to Ap