The Correlation of Irisin Levels and Some Trace Element as a Potential Mark Diagnosis of Gestational Diabetes Mellitus.

The objective of this project was investigating and comparing changes of serum irisin, and trace levels of the elements (Zn, Cu, Mg) in pregnant women with gestational diabetes mellitus GDM in addition to wholesome pregnant group, examining the correlation among (Zn, Cu, Mg) levels and irisin insulin impedance in GDM pregnant women. Sixty GDM pregnant women and thirty wholesome pregnant women were examined. The pair groups were matched for age, and maternal serum irisin. Insulin levels and gestational age were calculated by the assay for enzyme-linked immune sorbent kit at gestation at 24-28 weeks. The confederation between clinical and biochemical parameters and maternal serum irisin levels were predestined. Serum levels of glucose, body mass index, insulin, OGTT, HOMA IR, HOMAβ, HbA1c, Hb%, irisin, Zn, Cu and Mg were investigated and analyzed for the examined collection as well as control samples. Pregnant women with GDM disease had noteworthy rising fast blood glucose FBG (P=0.004), first-hour OGTT glucose (P=0.001), second-hour OGTT glucose (P=0.001), fasting insulin FI (P=0.001) levels, HOMA IR (P=0.001), HOMAβ (P=0.001), HbA1C (P=0.001), Hb% (P=0.017), as contrasted to healthy women. Levels of irisin serum were significantly minimizing (P=0.001) in women, and sequentially more advanced GDM (mean±SD=71.65±8.03) than healthy pregnant controls (mean±SD 136.54±22.56). Analyses among irisin levels of anthropometric and biochemical values in gestational diabetes patients disclosed that none of the scrupulousness values were remediated with serum irisin level. His present outcomes indicate that the levels of serum irisin might be presented as an incoming GDM marker with decreased irisin levels being GDM symptomatic

Assessing the role of serum Pentraxin-3 (PTX3) levels in hypothyroidism patients as risk marker of insulin resistance

Introduction. Hypothyroidism is a common endocrine disorder that affects millions of people worldwide. The diagnosis and monitoring of this condition often rely on thyroid hormone levels, which can be limited in their accuracy. Pentraxin 3 (PTX3) is a protein family that is involved in the innate immune response and is distinguished by its distinct pentameric structure

Perilipin-1 Level as Risk Marker of Insulin Resistance in Morbidly Obese Patients

Morbid obesity is a serious health condition that can interfere with basic physical functions such as breathing or walking. Those who are morbidly obese are at greater risk of illnesses including diabetes, high blood pressure, sleep apnea, gastro esophageal reflux disease, gallstones, osteoarthritis, heart disease, and cancer. This study was designed by taking 60 patients and 20 controls aged from 25 to 45 years with morbid obesity. A collection of samples was done by taking venous fasting blood samples from the patients and healthy volunteers after an overnight fasting. Insulin resistance (IR) was assessed using the homeostasis model assessment for insulin resistance (HOMA-IR), fasting blood glucose (FBG), glycated hemoglobin A1c (HbA1c) and lipid profile kits were used to determine these parameters. It was observed that the increase level of perilipin-1 led to insulin resistance and hyperinsulinemia for 60 patients, while the level of perilipin-1 in 20 controls caused insulin sensitivity. The increase of all studied parameters was concluded from the p-value, which was less than 0.05. The results also indicated that the level of perilipin-1 could be considered a risk factor for many diseases. It could cause accumulation of the bad cholesterol in vascular tissues leading to atherosclerosis; it could cause changes in many factors in secretion, could cause insulin resistance and then diabetes mellitus. The level of fatty acid coming from continuous lipolysis causes fatty liver and live diseases

Innovative Approaches to Thermal Management in Next-Generation Electronics

In conclusion, the analysis and measurement of thermal properties are crucial for a wide range of applications in science, technology, and industry. For energy efficiency optimisation, the design of sophisticated materials, and the creation of cutting-edge technologies, it is essential to comprehend how heat is transmitted and handled within materials. Researchers can precisely evaluate thermal conductivity, heat capacity, and other thermal parameters using a variety of experimental methodologies, including both conventional and cutting-edge technologies. This enables accurate material characterisation and performance evaluation. The landscape of thermal management and energy conversion has been significantly shaped by nanostructured materials. Their distinct nanoscale characteristics provide chances to modify thermal behaviour, boost effectiveness, and add new features. Researchers are able to manage heat conduction, phonon behaviour, and charge transport through the use of designed nanostructures, which has led to breakthroughs in a variety of industries, including electronics, energy storage, thermoelectric devices, and more. In addition to promoting energy efficiency and waste heat recovery, these developments pave the path for sustainable solutions to the world’s rising energy needs and environmental problems. We are on the verge of ground-breaking discoveries that have the potential to restructure industries, enhance energy sustainability, and pave the way for a more effective and linked society as we continue to investigate and harness the complex behaviour of heat within materials

Effect of Human MTHFR Gene Polymorphisms in Morbidly Obese Population on Elevate Risk of Type 2 Diabetes

In this paper, based on the association of methylenetetrahydrofolate reductase (MTHFR) with type 2 diabetes (T2D), we evaluated the association of polymorphism with morbidly obesity on risk type 2 diabetes. A case-control study of 74 health morbidly obese and 76 healthy non-obese was conducted in Iraq. MTHFR (C677T, A1298C and G1793A) genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The study revealed a significant association between cytidine/thymine (CT) genotype of C677T and morbid obesity (odds ratio (OR): 1.26, 95% confidence interval (CI): 0.91-1.60, probability (P) = 0.0003), but did not show any significant association in thymine/thymine (TT) genotype (OR: 0.258, 95% CI: 0.88-1.60, P = 0.082). On the other hand the second single nucleotide polymorphism (SNP) A1298C showed highly significant association in adenine/adenine (AA) genotype (OR: 1.39, 95% CI: 0.91-1.58, P = 0.0001) and significant association between adenine/cytidine (AC) and cytidine/cytidine (CC) genotypes (OR: 0.702, 95% CI: 0.88-1.61, P = 0.0377), (OR: 0.844, 95% CI: 0.91-1.59, P = 0.0273), respectively, but showed no significant relation in three types of normal homozygous, heterozygous and rare homozygous in MTHFR-G1793A. The results suggested that A1298C substitution might pose a direct effect on being type 2 diabetes in morbidly obese patients, and C677T had moderate effect, while G1793A had no effect. However, further case-control studies are required to provide a more robust conclusion

Type 2 Diabetes Mellitus Coincident with Clinical and Subclinical Thyroid Dysfunctions Results in Dysregulation of Circulating Chemerin, Resistin and Visfatin

The alterations of circulating adipocytokines have been reported in thyroid diseases or type 2 diabetes mellitus (T2DM), but such data in T2DM coincident with clinical and subclinical thyroid-dysfunctions are limited, and remain to be investigated. We studied the changes in serum chemerin, resisitin and visfatin in T2DM patients with thyroid dysfunctions, and their association with inflammatory and insulin resistance-markers. A total of 272 female and male Iranian participants were selected and divided into six groups: the euthyroid group, T2DM, T2DM coincident with clinical and sub clinical hypothyroidism (SC-HO, and C-HO), and T2DM coincident with clinical and sub clinical hyperthyroidism (SC-HR, C-HR).Demographic characteristics, serum levels of adipocytokines, thyroid hormones, inflammatory factors (IL1-β, IL-6 and CRP) and insulin resistance-markers were determined in all participants. T2DM patients with clinical thyroid dysfunctions showed higher levels of circulating resistin, visfatin, chemerin and inflammatory factors, compared with the T2DM group and T2DM coexisted with subclinical thyroid diseases. No significant differences were observed in circulating adipocytokines and inflammatory markers between T2DM coexisting with subclinical thyroid diseases and those without thyroid dysfunctions. Our results revealed that clinical thyroid dysfunction in T2DM patients was associated with elevated levels of circulating resistin, chemerin, visfatin and inflammatory factors, while no such alteration was detected in T2DM coincident with subclinical thyroid dysfunction

Revolutionizing Material Science: Exploring the Novel Applications of Thermally-Enhanced Processes in Next-Generation Materials

With the emergence of novel thermally accelerated methods, the area of material science has undergone a paradigm shift, opening up previously unimaginable possibilities for the creation of next-generation materials with improved properties and functionalities. In order to shape the materials of the future, this paper explores the ground-breaking uses of thermally accelerated techniques such quick thermal annealing, spark plasma sintering, and laser-assisted deposition. Due to sluggish diffusion rates and incomplete reactions, traditional materials synthesis and processing processes frequently have trouble producing materials with the appropriate characteristics. This allows for accurate atomic-level manipulation of material microstructures. The engineering of materials with specific mechanical, electrical, thermal, and optical properties is made possible by the fine-tuning of microstructures. The importance of thermally accelerated processes in a variety of material classes, including metals, ceramics, polymers, and composites, is highlighted in this research. The use of thermally enhanced processes shows potential in promoting sustainable practises, as materials play a crucial part in addressing global concerns. These procedures help to reduce waste and conserve resources by enabling the effective recycling and upcycling of materials through controlled thermal treatments. The report also highlights the potential effects of thermally enhanced techniques on future industries such as flexible electronics, renewable energy systems, and medicinal devices, where specialised materials with outstanding performance are crucial

Development of Multifunctional Nanomaterials and Devices for Biomedical Applications

The development of multifunctional nanomaterials and devices for biomedical applications has garnered significant attention in recent years due to their potential to revolutionize healthcare. In this study, we report the synthesis and characterization of novel nanomaterials with tailored properties for targeted drug delivery, imaging, and biosensing applications. We employed a bottom-up approach to design and fabricate nanocomposites comprising of biocompatible polymers, metallic nanoparticles, and quantum dots, which exhibit unique optical, magnetic, and electronic properties. The nanocomposites were functionalized with specific ligands to enable active targeting of cancer cells and pathogens. We also developed microfluidic devices for the efficient capture and analysis of circulating tumor cells (CTCs) using the synthesized nanomaterials. The performance of the nanomaterials and devices was evaluated in vitro and in vivo, demonstrating enhanced drug delivery efficiency, high-resolution imaging, and sensitive biosensing capabilities. Furthermore, we investigated the biocompatibility and long-term stability of the nanomaterials in physiological conditions. Our findings indicate that the developed multifunctional nanomaterials and devices hold great promise for advancing personalized medicine, early diagnosis, and targeted therapy. This study provides a comprehensive understanding of the design principles and potential applications of multifunctional nanomaterials in the biomedical field, paving the way for future research and clinical translation

Characterization and Modelling of Nanomaterials Synthesized by Chemical Vapor Deposition

In recent years, Chemical Vapor Deposition (CVD) has emerged as a pivotal technique for the synthesis of high-quality nanomaterials, owing to its ability to produce uniform and scalable thin films with controlled properties. This study presents a comprehensive characterization and modelling of nanomaterials synthesized via CVD, elucidating the intricate relationship between process parameters and the resultant material properties. Utilizing advanced characterization techniques, including Transmission Electron Microscopy (TEM), XPS, and Raman Spectroscopy, we have discerned the morphological, compositional, and structural attributes of the synthesized nanomaterials. The experimental data were subsequently employed to develop a predictive model, leveraging machine learning algorithms, to forecast the properties of nanomaterials based on CVD parameters. The model exhibited high accuracy and can serve as a robust tool for optimizing CVD processes in real-time. Our findings underscore the potential of CVD in tailoring nanomaterial properties for specific applications and provide a foundational framework for researchers and industries aiming to harness the full potential of nanomaterials synthesized via CVD. This work not only advances our understanding of CVD-synthesized nanomaterials but also paves the way for their application in next-generation electronic, photonic, and energy devices

Advanced Modelling and Simulation of Intermetallic Reinforced Composites for Structural and Functional Applications

In recent years, intermetallic reinforced composites (IRCs) have garnered significant attention due to their exceptional mechanical properties, corrosion resistance, and high-temperature stability, making them ideal candidates for both structural and functional applications. This research paper presents an advanced modelling and simulation approach to understand the microstructural evolution, mechanical behaviour, and functional properties of IRCs. Utilizing a combination of finite element analysis (FEA), molecular dynamics (MD), and phase-field modelling, the study offers a comprehensive insight into the intricate interplay between the matrix, reinforcement, and the resultant composite behaviour. The developed models accurately predict the stress-strain response, thermal conductivity, and fatigue life of the IRCs under various loading and environmental conditions. Furthermore, the simulations provide a detailed understanding of the mechanisms governing crack initiation and propagation in these composites. The outcomes of this research not only pave the way for optimizing the design and processing parameters of IRCs but also underscore the potential of these materials in aerospace, automotive, and energy sectors. The findings presented herein serve as a foundational reference for researchers and engineers aiming to harness the full potential of intermetallic reinforced composites in advanced engineering applications