Virtually Authentic: Graduate Students’ Perspective Changes toward Authentic Learning while Collaborating in a Virtual World

This qualitative case study investigates graduate students’ perspective changes apropos their cross-national collaborative learning experience while participating in an online teaching and learning course jointly taught by graduate schools in the United States and Israel. The participants met virtually, on a weekly basis between November and December 2018, on a platform called Second Life, to design and participate in collaborative learning activities. On completion of the course, interviews were conducted with a small sample of student-participants regarding their experiences. During the design phase, participants’ dominant perceptions of their learning experiences were characterized by genuine “excitement” at the novelty of collaborating virtually with colleagues on the other side of the world. Their initial perceptions evolved during the participation phase to realization as learning communities emerged and students’ roles expanded beyond the scope of mere participants. In this study, the authors argue that participants’ construction of new knowledge resulted in authentic learning from the standpoints of social constructivism and online collaborative learning theory and further discuss the factors that enabled the participants’ authentic learning experience

Synthesis and characterization of novel astragalin galactosides using b-galactosidase from Bacillus circulans

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Enzymatic synthesis of chlorogenic acid glucoside using dextransucrase and its physical and functional properties

Chlorogenic acid, a major polyphenol in edible plants, possesses strong antioxidant activity, anti-lipid peroxidation and anticancer effects. It used for industrial applications; however, this is limited by its instability to heat or light. In this study, we, for the first time synthesized chlorogenic acid glucoside (CHG) via transglycosylation using dextransucrase from Leuconostoc mesenteroides and sucrose. CHG was purified and its structure determined by nuclear magnetic resonance and matrix-associated laser desorption ionization–time-of-flight mass spectroscopy. The production yield of CHG was 44.0% or 141 mM, as determined by response surface methodology. CHG possessed a 65% increase in water solubility and a 2-fold browning resistance and it displayed stronger inhibition of lipid peroxidation and of colon cancer cell growth by MTT assay, compared to chlorogenic acid. Therefore, this study may expand the industrial applications of chlorogenic acid as water-soluble or browning resistant compound (CHG) through enzymatic glycosylation

Polymer Micelle Formulation for the Proteasome Inhibitor Drug Carfilzomib: Anticancer Efficacy and Pharmacokinetic Studies in Mice

Carfilzomib (CFZ) is a peptide epoxyketone proteasome inhibitor approved for the treatment of multiple myeloma (MM). Despite the remarkable efficacy of CFZ against MM, the clinical trials in patients with solid cancers yielded rather disappointing results with minimal clinical benefits. Rapid degradation of CFZ in vivo and its poor penetration to tumor sites are considered to be major factors limiting its efficacy against solid cancers. We previously reported that polymer micelles (PMs) composed of biodegradable block copolymers poly(ethylene glycol) (PEG) and poly(caprolactone) (PCL) can improve the metabolic stability of CFZ in vitro. Here, we prepared the CFZ-loaded PM, PEG-PCL-deoxycholic acid (CFZ-PM) and assessed its in vivo anticancer efficacy and pharmacokinetic profiles. Despite in vitro metabolic protection of CFZ, CFZ-PM did not display in vivo anticancer efficacy in mice bearing human lung cancer xenograft (H460) superior to that of the clinically used cyclodextrin-based CFZ (CFZ-CD) formulation. The plasma pharmacokinetic profiles of CFZ-PM were also comparable to those of CFZ-CD and the residual tumors that persisted in xenograft mice receiving CFZ-PM displayed an incomplete proteasome inhibition. In summary, our results showed that despite its favorable in vitroperformances, the current CFZ-PM formulation did not improve in vivo anticancer efficacy and accessibility of active CFZ to solid cancer tissues over CFZ-CD. Careful consideration of the current results and potential confounding factors may provide valuable insights into the future efforts to validate the potential of CFZ-based therapy for solid cancer and to develop effective CFZ delivery strategies that can be used to treat solid cancers

Growth, Emission, and Mitigation Aid in Developing Countries

This paper aims to examine the relationship between growth and pollution, especially in developing countries that struggle with adverse effects caused by the climate crisis. By using the Environmental Kuznets Curve (EKC) framework, the effect of GDP on four air pollutants was investigated with a panel data of 91 countries for 10 years. Only carbon dioxide without control variables showed EKC and climate change mitigation aid was significantly negative to only greenhouse gas emission

Creating a maker course syllabus for the Learning Technologies program : bridging experiences between the UT Campus makerspace and K-12 makerspaces in Austin, Texas

The goal of this report is the development of a new maker course syllabus and course plan for the Learning Technologies program at the University of Texas at Austin (UT Austin). This course will provide hands-on making experiences for graduate students in ‘The Foundry’ (UT Makerspace) and subsequently bridge those experiences to K-12 makerspaces in Austin. This report contains four major sections. First, the report begins with a literature review of makerspaces and learning, making and assessment, and making in both K-12 and higher education, supported by a review of empirical studies and web-based articles. Second, the context for the development of a graduate level maker course is explained through the analysis of The Foundry’s support for graduate students’ making activities and the summary of my visits to K-12 makerspaces in Austin, Texas. Third, existing maker courses from three different universities—Teaching for Creativity and Innovation (University of Wisconsin-Stout), Critical Making (University of California, Berkeley), and Introduction to Design and Making (University of North Carolina at Chapel Hill)—are analyzed to gather ideas for a new maker course syllabus. Additionally, I analyze current courses offered by the Learning Technologies program to evaluate the justification for a new maker course for graduate students. Finally, the fourth section details the new maker course syllabus I created.Curriculum and Instructio

Willingness to Pay for the Public Electric Bus in Nepal: A Contingent Valuation Method Approach

The rapid increase in conventional diesel and gasoline vehicles in developing countries draws attention to clean energy vehicles, including electric buses. From socioeconomic and environmental perspectives, the benefits of electric buses are well described; however, there is a lack of studies to analyze the willingness to pay (WTP). This study aims to estimate 500 residents’ WTP in Pokhara Metropolitan City in Nepal, based on a contingent valuation method (CVM). The survey results show that 78% of respondents are willing to pay a special monthly tax for introducing electric buses in the city primarily due to the fact that electric buses are likely to be helpful to the environment (82.3%). Using the logistic regression analysis, it is estimated that the mean WTP is 758.6 NPR per person, with the most influencing factors of ‘willingness to ride electric buses for free’ and ‘the average usage of the main transportation per week’. The variables that show a positive relationship with the WTP are ‘the average usage of the main transportation per week’, ‘willingness to ride electric buses for free’, and ‘age’. The variable that negatively correlates with the WTP is ‘age’. The study’s findings provide references for developing funding options and budgeting plans for local policymakers

Emerging immunotherapy for the treatment of esophageal cancer

Introduction: Esophageal cancer is the third most common cancer of the gastrointestinal tract. Despite new therapies, the prognosis for patients with these cancers remains poor with 5-year survival rates lower than 15%. Recently, immunotherapy has increasingly gained attention as a novel treatment strategy for advanced esophageal cancer. Areas covered: Recent success of immunotherapy in treating other solid tumors has shed light on the utility of these approaches for esophageal cancers. Here, the authors focus on antibody-based, adoptive-cell-therapy-based, and vaccine-based immunotherapies, and briefly address their rationale, clinical data, and implications. Expert opinion: Immunotherapy is now established to be a key treatment modality that can improve the outcomes of many cancer patients and appears to be ushering in a new era in cancer treatment. Checkpoint inhibitor drugs have shown preliminary favorable results in esophageal cancer treatment. Adoptive cell therapy and vaccine studies have also shown some promise in various clinical studies. Future endeavors will need to focus on identifying patients who are likely to benefit from immunotherapy, monitoring and managing immune responses and designing optimal combination strategies where immunotherapy agents are combined with other traditional treatment modalities

Willingness to Pay for the Public Electric Bus in Nepal: A Contingent Valuation Method Approach

The rapid increase in conventional diesel and gasoline vehicles in developing countries draws attention to clean energy vehicles, including electric buses. From socioeconomic and environmental perspectives, the benefits of electric buses are well described; however, there is a lack of studies to analyze the willingness to pay (WTP). This study aims to estimate 500 residents’ WTP in Pokhara Metropolitan City in Nepal, based on a contingent valuation method (CVM). The survey results show that 78% of respondents are willing to pay a special monthly tax for introducing electric buses in the city primarily due to the fact that electric buses are likely to be helpful to the environment (82.3%). Using the logistic regression analysis, it is estimated that the mean WTP is 758.6 NPR per person, with the most influencing factors of ‘willingness to ride electric buses for free’ and ‘the average usage of the main transportation per week’. The variables that show a positive relationship with the WTP are ‘the average usage of the main transportation per week’, ‘willingness to ride electric buses for free’, and ‘age’. The variable that negatively correlates with the WTP is ‘age’. The study’s findings provide references for developing funding options and budgeting plans for local policymakers