Spatio-temporal Keyframe Control of Traffic Simulation using Coarse-to-Fine Optimization

We present a novel traffic trajectory editing method which uses spatio-temporal keyframes to control vehicles during the simulation to generate desired traffic trajectories. By taking self-motivation, path following and collision avoidance into account, the proposed force-based traffic simulation framework updates vehicle's motions in both the Frenet coordinates and the Cartesian coordinates. With the way-points from users, lane-level navigation can be generated by reference path planning. With a given keyframe, the coarse-to-fine optimization is proposed to efficiently generate the plausible trajectory which can satisfy the spatio-temporal constraints. At first, a directed state-time graph constructed along the reference path is used to search for a coarse-grained trajectory by mapping the keyframe as the goal. Then, using the information extracted from the coarse trajectory as initialization, adjoint-based optimization is applied to generate a finer trajectory with smooth motions based on our force-based simulation. We validate our method with extensive experiments

Chronic Heat Stress Weakened the Innate Immunity and Increased the Virulence of Highly Pathogenic Avian Influenza Virus H5N1 in Mice

Chronic heat stress (CHS) can negatively affect immune response in animals. In this study we assessed the effects of CHS on host innate immunity and avian influenza virus H5N1 infection in mice. Mice were divided into two groups: CHS and thermally neutral (TN). The CHS treatment group exhibited reduced local immunity in the respiratory tract, including the number of pulmonary alveolar macrophages and lesions in the nasal mucosa, trachea, and lungs. Meanwhile, CHS retarded dendritic cells (DCs) maturation and reduced the mRNA levels of IL-6 and IFN-β significantly (P < .05). After the CHS treatment, mice were infected with H5N1 virus. The mortality rate and viral load in the lungs of CHS group were higher than those of TN group. The results suggest that the CHS treatment could suppress local immunity in the respiratory tract and innate host immunity in mice significantly and moderately increased the virulence in H5N1-infected mice

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