Analysis of small-diameter wood supply in northern Arizona - Final report

Forest management to restore fire-adapted ponderosa pine ecosystems is a central priority of the Southwestern Region of the USDA Forest Service. Appropriately-scaled businesses are apt to play a key role in achieving this goal by harvesting, processing and selling wood products, thereby reducing treatment costs and providing economic opportunities. The manner in which treatments occur across northern Arizona, with its multiple jurisdictions and land management areas, is of vital concern to a diversity of stakeholder groups. To identify a level of forest thinning treatments and potential wood supply from restoration byproducts, a 20-member working group representing environmental non-governmental organizations (NGOs), private forest industries, local government, the Ecological Restoration Institute at Northern Arizona University (NAU), and state and federal land and resource management agencies was assembled. A series of seven workshops supported by Forest Ecosystem Restoration Analysis (ForestERA; NAU) staff were designed to consolidate geographic data and other spatial information and to synthesize potential treatment scenarios for a 2.4 million acre analysis area south of the Grand Canyon and across the Mogollon Plateau. A total of 94% of the analysis area is on National Forest lands. ForestERA developed up-to-date remote sensing-based forest structure data layers to inform the development of treatment scenarios, and to estimate wood volume in three tree diameter classes of 16" diameter at breast height (dbh, 4.5' above base). For the purposes of this report, the group selected a 16" dbh threshold due to its common use within the analysis landscape as a break point differentiating "small" and "large" diameter trees in the ponderosa pine forest type. The focus of this study was on small-diameter trees, although wood supply estimates include some trees >16" dbh where their removal was required to meet desired post-treatment conditions.4 There was no concurrence within the group that trees over 16" dbh should be cut and removed from areas outside community protection management areas (CPMAs)..

\u3cem\u3eDACH1\u3c/em\u3e Mutation Frequency in Endometrial Cancer Is Associated with High Tumor Mutation Burden

OBJECTIVE: DACH1 is a transcriptional repressor and tumor suppressor gene frequently mutated in melanoma, bladder, and prostate cancer. Loss of DACH1 expression is associated with poor prognostic features and reduced overall survival in uterine cancer. In this study, we utilized the Oncology Research Information Exchange Network (ORIEN) Avatar database to determine the frequency of DACH1 mutations in patients with endometrial cancer in our Kentucky population. METHODS: We obtained clinical and genomic data for 65 patients with endometrial cancer from the Markey Cancer Center (MCC). We examined the clinical attributes of the cancers by DACH1 status by comparing whole-exome sequencing (WES), RNA Sequencing (RNASeq), microsatellite instability (MSI), and tumor mutational burden (TMB). RESULTS: Kentucky women with endometrial cancer had an increased frequency of DACH1 mutations (12/65 patients, 18.5%) compared to The Cancer Genome Atlas (TCGA) endometrial cancer population (25/586 patients, 3.8%) with p-value = 1.04E-05. DACH1 mutations were associated with increased tumor mutation count in both TCGA (median 65 vs. 8972, p-value = 7.35E-09) and our Kentucky population (490 vs. 2160, p-value = 6.0E-04). DACH1 mutated patients have a higher tumor mutation burden compared to DACH1 wild-type (24 vs. 6.02, p-value = 4.29E-05). DACH1 mutations showed significant gene co-occurrence patterns with POLE, MLH1, and PMS2. DACH1 mutations were not associated with an increase in microsatellite instability at MCC (MSI-H) (p-value = 0.1342). CONCLUSIONS: DACH1 mutations are prevalent in Kentucky patients with endometrial cancer. These mutations are associated with high tumor mutational burden and co-occur with genome destabilizing gene mutations. These findings suggest DACH1 may be a candidate biomarker for future trials with immunotherapy, particularly in endometrial cancers

Best practices for virtual participation in meetings : experiences from synthesis centers

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A global database of lake surface temperatures collected by in situ and satellite methods from 1985–2009

Global environmental change has influenced lake surface temperatures, a key driver of ecosystem structure and function. Recent studies have suggested significant warming of water temperatures in individual lakes across many different regions around the world. However, the spatial and temporal coherence associated with the magnitude of these trends remains unclear. Thus, a global data set of water temperature is required to understand and synthesize global, long-term trends in surface water temperatures of inland bodies of water. We assembled a database of summer lake surface temperatures for 291 lakes collected in situ and/or by satellites for the period 1985–2009. In addition, corresponding climatic drivers (air temperatures, solar radiation, and cloud cover) and geomorphometric characteristics (latitude, longitude, elevation, lake surface area, maximum depth, mean depth, and volume) that influence lake surface temperatures were compiled for each lake. This unique dataset offers an invaluable baseline perspective on global-scale lake thermal conditions as environmental change continues

Ribosome-Associated Vesicles promote activity-dependent local translation

Local protein synthesis in axons and dendrites underpins synaptic plasticity. However, the composition of the protein synthesis machinery in distal neuronal processes and the mechanisms for its activity-driven deployment to local translation sites remain unclear. Here, we employed cryo-electron tomography, volume electron microscopy, and live-cell imaging to identify Ribosome-Associated Vesicles (RAVs) as a dynamic platform for moving ribosomes to distal processes. Stimulation via chemically-induced long-term potentiation causes RAV accumulation in distal sites to drive local translation. We also demonstrate activity-driven changes in RAV generation and dynamics , identifying tubular ER shaping proteins in RAV biogenesis. Together, our work identifies a mechanism for ribosomal delivery to distal sites in neurons to promote activity-dependent local translation

Rapid and highly variable warming of lake surface waters around the globe

In this first worldwide synthesis of in situ and satellite-derived lake data, we find that lake summer surface water temperatures rose rapidly (global mean = 0.34°C decade-1) between 1985 and 2009. Our analyses show that surface water warming rates are dependent on combinations of climate and local characteristics, rather than just lake location, leading to the counterintuitive result that regional consistency in lake warming is the exception, rather than the rule. The most rapidly warming lakes are widely geographically distributed, and their warming is associated with interactions among different climatic factors - from seasonally ice-covered lakes in areas where temperature and solar radiation are increasing while cloud cover is diminishing (0.72°C decade-1) to ice-free lakes experiencing increases in air temperature and solar radiation (0.53°C decade-1). The pervasive and rapid warming observed here signals the urgent need to incorporate climate impacts into vulnerability assessments and adaptation efforts for lakes