201: Are QT intervals correlated to apnea-hypopnea index in obstructive sleep apnea?

IntroductionSeveral studies proved that obstructive sleep apnea (OSA) is associated with cardio-vascular diseases such as cardiac arrhythmia. QT duration and dispersion reflect the heterogeinity of ventricular repolarization and are considered as precursors of ventricular arrhythmiaAimThe aim of this study is to assess the relation between the severity of OSA parameters as apnea hypopnea index and QT intervals.MethodsForty patients (18 men and 22 women) who were diagnosed with OSA by overnight polysomnography were included in this prospective study. The mean age was 56±10 years old. They were all in sinus rhythm. Before initiating continuous positive airway pressure therapy, we calculated on a 12 lead ECG : QT duration (QTend) corrected to Bazett formula and QT dispersion (QT end max -QT end min).ResultsTwenty four patients had severe OSA (AHI >30), 4 had moderate OSA (AHI between 15 and 30) and 12 had a mild OSA (AHI between 5 and 15). There was a significant positive correlation between QT dispersion and AHI (r=0.48, p=0.001)ConclusionThe severity of OSA seems to be correlated with ventricular repolarization heterogeinity These results suggest that the higher is the AHI the higher is the risk of ventricular arrhythmia occurence. Further studies are needed to validate these results

Knowledge, attitudes and practices of sheep owners regarding abortion in Northern Tunisia

Abstract Background Abortion in ewes causes high economic losses and represents a threat for human health due to abortive zoonotic pathogens. Objective The present study aimed to assess the knowledge, attitudes and practices (KAP) among sheep owners in the northern Tunisia regarding ewes’ abortions. Methods Between February 2021 and May 2022, a structured questionnaire containing both close and open‐ended questions was applied to 120 sheep owners in northern Tunisia. The data collected were analysed by chi‐square test using Epi info 6 software. Results The majority (75%) of participants reported a history of abortion in their sheep flocks. Sheep owners thought that the most frequent cause of abortion was physical factors, such as trauma, climate and stress (60% ± 5.5%; 48/80), followed by toxicity (15% ± 4%; 12/80), metabolic and nutritional conditions (12.5% ± 3.7%; 10/80), vaccination (5% ± 2.4%; 4/80) and infectious causes (7.5% ± 2.9%; 6/80) (p < 0.001). The majority of animal owners reported that abortions occurred mainly during autumn (39.6% ± 5%; 38/96), followed by summer (27% ± 4.5%; 26/96), winter (23% ± 4.3%; 22/96) and spring (10.4% ± 3.1%; 10/96) (p < 0.001). Approximately, half (45.8% ± 5%; 55/120) of interviewed farmers would not take any action if an abortion occurred. Half of the interviewed farmers (50.5% ± 5.1%; 48/95) did not apply any preventive measures when manipulating aborted ewes, and most of the sheep owners (77.3% ± 3.8%; 92/119) did not know that aborted ewes could transmit zoonotic pathogens. Conclusions Our survey concluded that sheep owners in Northern Tunisia had poor knowledge and attitudes as well as applied limited actions concerning several health aspects related to abortion. Education programmes should be established in order to improve Tunisian sheep owners’ KAP regarding abortion

Exploring multisite musculoskeletal symptoms among sewing machine operators in a tunisian leather and footwear industry using decision tree models

Background/objectives: Sewing machine operators (SMO) are the most likely workers to experience a high prevalence of musculoskeletal disorders in the textile, clothing, and footwear industries. We conducted a cross-sectional and exhaustive study among SMO working in the leather and footwear industry to describe the prevalence of multi-site musculoskeletal symptoms (MMS) and evaluate factors associated with their occurrence. Methods: Musculoskeletal symptoms declared by these operators were assessed through the modified Nordic questionnaire. The psychosocial work environment was assessed using the Karasek model. The variables associated with MMS were issued from binary logistic regression and decision tree using R software. Results: Of 145 operators, 65.5 % of men and 72.4 % of women had MMS. Based on binary logistic regression, a history of musculoskeletal disorders (MSDs) increased the risk of developing MMS by 8 folds. The binary decision tree identified five main nodes: history of MSDs, professional seniority, often finding the pace of work restrictive and male gender. Conclusion: Identifying homogeneous profiles of MMS's occurrence will help the implementation of an effective and targeted preventive strategy

Influence of garlic or its main active component diallyl disulfide on iron bioavailability and toxicity

Abstract Garlic is regularly consumed and is known to have diverse biologic activities, particularly due to its antioxidant properties. In this study, we hypothesized that crude garlic can prevent iron-mediated oxidative stress in a rat model of nutritional iron overload, and we used an in vitro model to confirm the results. For the in vivo studies, rats received a basal diet supplemented with or without carbonyl iron (3%) and were fed distilled water or garlic solution (1g/kg body weight) by gavage for 3 weeks. The presence of both garlic and iron led to a 2-fold increase in plasma iron and a 50% increase in liver iron as compared with iron alone. However, garlic did not offer any protection against iron-induced oxidative stress. Duodenal divalent metal transporter-1 mRNA expression was fully repressed by iron and by the combined treatments but was also reduced by garlic alone. To confirm these data, we tested the effect of diallyl disulfide, one of the active components in garlic, in vitro on polarized Caco-2 cells. A 24-hour treatment decreased iron uptake at the apical side of Caco-2 cells but increased the percentage of iron transfer at the basolateral side. This probably resulted from a modest induction of ferroportin mRNA and protein expression. These results suggest that garlic, when given in the presence of iron, enhances iron absorption by increasing ferroportin expression. The presence of garlic in the diet at the dose studied does not seem to protect against iron-mediated oxidative stress

High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure

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