Core Design Pattern for Efficient Multi-agent Architecture

Interaction engineering is fundamental for agent based systems. In this paper we will present a design pattern for the core of a multi-agent platform - the message communication and behavior activation mechanisms - using language features of C#. An agent platform is developed based on the pattern structure, which is legiti- mated through experiences of using JADE in real applications. Results of the communication model are compared against the popular JADE platform

Core Design Pattern for Efficient Multi-agent Architecture

Interaction engineering is fundamental for agent based systems. In this paper we will present a design pattern for the core of a multi-agent platform - the message communication and behavior activation mechanisms - using language features of C#. An agent platform is developed based on the pattern structure, which is legiti- mated through experiences of using JADE in real applications. Results of the communication model are compared against the popular JADE platform

Massive pulmonary embolism presenting as disseminated intravascular coagulation.

Disseminated intravascular coagulation (DIC) can be defined as evidence of activation of the coagulation mechanism resulting in proteolysis of fibrinogen by thrombin and plasmin and an acute thrombocytopenia. The association of pulmonary embolism (PE) with DIC has recently been reported but in reviewing recent textbooks of hematology, there is no mention of PE as a cause of DIC. Clinicians need to be made aware of this association since it affects the patient who is thought to be autoanticoagulated as well as the patient who has DIC of unknown cause. PE needs to be included in the differential diagnosis of an autoanticoagulated state and in DIC of unknown etiology. In both instances the recommended treatment is full-dose intravenous heparin therapy

Transfer of Development Process Knowledge Through Method Adaption and Implementation

Knowledge transfer is one of the key problem areas in knowledge management. This paper focuses on the transfer of knowledge about the software development process. There is an aim to improve process knowledge and one way of doing it is to introduce commercial development methods. However, doing this is not an easy task. We present a study of how such an introduction of a widespread method was carried out in two large software development organisations. We conclude that a new method has to be adapted and implemented in the organisation in order to make it a part of the organisation specific knowledge base. The new method has to become an integrated part of the existing development process knowledge of the organisation, meaning that it has to be adapted to fit with other organisation specific processes. The ability to do so is the absorptive capacity: the capability to identify and recognise the value of new external knowledge, assimilate it, and apply it

Personcentrerat arbetsklimat på en akutmottagning och inom ambulans En enkätstudie

Bakgrund: Sjukvården är idag, i hög grad, organiserad utifrån diagnoser. Personcentrerad vård ämnar skapa en fungerande relation mellan vårdgivare och patient där denne blir sedd och förstådd som en unik individ med individuella behov, värderingar och förväntningar För implementering av personcentrerad vård krävs dock förändring i sättet att se på sjukvårdens arbetsklimat gällande dess förutsättningar och begränsningar. Syfte: Syftet med studien var att undersöka i vilken utsträckning akutvårds – och ambulans-personal upplever att deras verksamhets arbetsklimat var personcentrerat. Metod: Föreliggande studie var en tvärsnittsstudie med kvantitativ ansats utförd utifrån en enkät. Enkäten bestod av 14 påståenden och undersökte hur väl personal på en akut-mottagning och i ett ambulansdistrikt upplevde sin arbetsplats klimat som personcentrerat. Resultat: Studien visade på ett signifikant högre upplevt personcentrerat arbetsklimat hos ambulanspersonalen i jämförelse med akutmottagningens personal. Dock placerar sig de båda verksamheterna lågt i förhållande till de framtagna cut off scores som fanns för enkäten. Om förutsättningen för PCV är ett personcentrerat arbetsklimat visar denna studie en stor problematik hos de båda organisationerna

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

The ubiquitin ligase MDM2 is best known for balancing the activity of the tumor suppressor p53. We have previously shown that MDM2 is vital for adipocyte conversion through controlling Cebpd expression in a p53-independent manner. Here, we show that the proadipogenic effect of MDM2 relies on activation of the STAT family of transcription factors. Their activation was required for the cAMP-mediated induction of target genes. Interestingly, rather than influencing all cAMP-stimulated genes, inhibition of the kinases directly responsible for STAT activation, namely JAKs, or ablation of MDM2, each resulted in abolished induction of a subset of cAMP-stimulated genes, with Cebpd being among the most affected. Moreover, STATs were able to interact with the transcriptional cofactors CRTC2 and CRTC3, hitherto only reported to associate with the cAMP-responsive transcription factor CREB. Last but not least, the binding of CRTC2 to a transcriptional enhancer that interacts with the Cebpd promoter was dramatically decreased upon JAK inhibition. Our data reveal the existence of an unusual functional interplay between STATs and CREB at the onset of adipogenesis through shared CRTC cofactors