1,101 research outputs found
Chronic lymphocytic leukaemia: Up-dated recommendations on diagnosis and treatment
Diagnosis and treatment of chronic lymphatic leukaemia (CLL) are currently undergoing great change. New knowledge of prognosis factors and the numerous new therapeutic procedures now available, such as purine analogues, high-dose treatment and monoclonal antibodies are making major contributions to this progress. As a consequence, the options for treatment of CLL are considerably more diverse now than a few years ago, and now include procedures that take into account age and risk. At the same time, it should be emphasized that many important questions regarding the treatment of CLL remain unresolved. It is anticipated that these questions will be answered over the coming few years by including patients in multicentre studies like those being carried out by the German CLL study group
Progress in the use of adeno-associated viral vectors for gene therapy
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the parvovirus family. The advantages of this vector system is the stability of the viral capsid, the low immunogenicity, the ability to transduce both dividing and non-dividing cells, the potential to integrate site specifically and to achieve long-term gene expression even in vivo, and its broad tropism allowing the efficient transduction of diverse organs including the skin. All this makes AAV-2 attractive and efficient for in vitro gene transfer and local injection in vivo. This review covers the progress made in AAV vector technology including the development of AAV vectors based on other serotypes, summarizes the results obtained by AAV targeting vectors and outlines potential applications in the field of cutaneous gene therapy. Copyright (C) 2004 S. Karger AG, Basel
Studies on the rare of central catecholaminergic mechanisms in the antidotal effect of the oxime HI 6 in soman poisoned mice
Circadian variation of the atropine effect on the running performance of mice treated with 1,2,2-trimethylpropylmethylphosphonofluoridate (soman)
Circadian variation of the atropine effect on the running performance of mice treated with 1,2,2-trimethylpropylmethylphosphonofluoridate (soman)
Chronopharmacology of mitoxantrone (MX): Evodence for a circadian rhythm of its myelotoxicity from an animal model and a clinical pilot trial
Ciradian dysrhythmias in the EEG of children with clonazepam treatment
The effects of different anticonvulsants on the system of cir-cadian and ultradian rhythms in the EEG of children was investigated
in ten 24*-h recordings of children with different forms
of epilepsy. Circadian dysrhythmias could be found in children
with Clonazepam treatment
Circadian dysrythmia in the behavior of epileptic children with clonazepam and/or phenobarbital treatment.
Effect of unequal twice daily theophylline on the circadian variation in the expression of ß2-adrenoceptor on peripheral mononuclear leucocytes
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