Accumulation of Vesicle-Associated Human Tau in Distal Dendrites Drives Degeneration and Tau Secretion in an In Situ Cellular Tauopathy Model

We used a nontransgenic cellular tauopathy model in which individual giant neurons in the lamprey CNS (ABCs) overexpress human tau isoforms cell autonomously to characterize the still poorly understood consequences of disease-associated tau processing in situ. In this model, tau colocalizes with endogenous microtubules and is nontoxic when expressed at low levels, but is misprocessed by a toxicity-associated alternative pathway when expressed above levels that saturate dendritic microtubules, causing abnormally phosphorylated, vesicle-associated tau to accumulate in ABC distal dendrites. This causes localized microtubule loss and eventually dendritic degeneration, which is preceded by tau secretion to the extracellular space. This sequence is reiterated at successively more proximal dendritic locations over time, suggesting that tau-induced dendritic degeneration is driven by distal dendritic accumulation of hyperphosphorylated, vesicle-associated tau perpetuated by localized microtubule loss. The implications for the diagnosis and treatment of human disease are discussed

Possible Supersymmetric Effects on Angular Distributions in B→K∗(→Kπ)ℓ+ℓ−B \to K^* (\to K \pi) \ell^+ \ell^- Decays

We investigate the angular distributions of the rare B decay, $B \to K^* (\to K \pi) \ell^+ \ell^-$, in general supersymmetric extensions of the standard model. We consider the new physics contributions from the operators $O_{7,8,9,10}$ in small invariant mass region of lepton pair. We show that the azimuthal angle distribution of the decay can tell us the new physics effects clearly from the behavior of the distribution, even if new physics does not change the decay rate substantially from the standard model prediction

Quark Mass Textures and sin 2 beta

Recent precise measurements of sin 2 beta from the B-factories (BABAR and BELLE) and a better known strange quark mass from lattice QCD make precision tests of predictive texture models possible. The models tested include those hierarchical N-zero textures classified by Ramond, Roberts and Ross, as well as any other hierarchical matrix Ansatz with non-zero 12 = 21 and vanishing 11 and 13 elements. We calculate the maximally allowed value for sin 2 beta in these models and show that all the aforementioned models with vanishing 11 and 13 elements are ruled out at the 3 sigma level. While at present sin 2 beta and |Vub/Vcb| are equally good for testing N-zero texture models, in the near future the former will surpass the latter in constraining power.Comment: 1+20 pages, 2 figures, JHEP3 clas

Efficient magneto-optical trapping of Yb atoms with a violet laser diode

We report the first efficient trapping of rare-earth Yb atoms with a high-power violet laser diode (LD). An injection-locked violet LD with a 25 mW frequency-stabilized output was used for the magneto-optical trapping (MOT) of fermionic as well as bosonic Yb isotopes. A typical number of $4\times 10^6$ atoms for $^{174}$Yb with a trap density of $\sim 1\times10^8/$cm$^3$ was obtained. A 10 mW violet external-cavity LD (ECLD) was used for the one-dimensional (1D) slowing of an effusive Yb atomic beam without a Zeeman slower resulting in a 35-fold increase in the number of trapped atoms. The overall characteristics of our compact violet MOT, e.g., the loss time of 1 s, the loading time of 400 ms, and the cloud temperature of 0.7 mK, are comparable to those in previously reported violet Yb MOTs, yet with a greatly reduced cost and complexity of the experiment.Comment: 5 pages, 3 figures, 1 table, Phys. Rev. A (to be published

Inflationary Cosmology with Five Dimensional SO(10)

We discuss inflationary cosmology in a five dimensional SO(10) model compactified on $S^1/(Z_2\times Z_2')$, which yields $SU(3)_c\times SU(2)_L\times U(1)_Y\times U(1)_X$ below the compactification scale. The gauge symmetry $SU(5)\times U(1)_X$ is preserved on one of the fixed points, while ``flipped'' $SU(5)'\times U(1)'_X$ is on the other fixed point. Inflation is associated with $U(1)_X$ breaking, and is implemented through $F$-term scalar potentials on the two fixed points. A brane-localized Einstein-Hilbert term allows both branes to have positive tensions during inflation. The scale of $U(1)_X$ breaking is fixed from $\delta T/T$ measurements to be around $10^{16}$ GeV, and the scalar spectral index $n=0.98-0.99$. The inflaton field decays into right-handed neutrinos whose subsequent out of equilibrium decay yield the observed baryon asymmetry via leptogenesis.Comment: 1+19 pages, improved discussion of 5D cosmology, Version to appear in PR

Non-Relativistic Spacetimes with Cosmological Constant

Recent data on supernovae favor high values of the cosmological constant. Spacetimes with a cosmological constant have non-relativistic kinematics quite different from Galilean kinematics. De Sitter spacetimes, vacuum solutions of Einstein's equations with a cosmological constant, reduce in the non-relativistic limit to Newton-Hooke spacetimes, which are non-metric homogeneous spacetimes with non-vanishing curvature. The whole non-relativistic kinematics would then be modified, with possible consequences to cosmology, and in particular to the missing-mass problem.Comment: 15 pages, RevTeX, no figures, major changes in the presentation which includes a new title and a whole new emphasis, version to appear in Clas. Quant. Gra

Family Unification on an Orbifold

We construct a family-unified model on a Z_2xZ_2 orbifold in five dimensions. The model is based on a supersymmetric SU(7) gauge theory. The gauge group is broken by orbifold boundary conditions to a product of grand unified SU(5) and SU(2)xU(1) flavor symmetry. The structure of Yukawa matrices is generated by an interplay between spontaneous breaking of flavor symmetry and geometric factors arising due to field localization in the extra dimension.Comment: 13 page

Supersymmetric Extension of the Standard Model with Naturally Stable Proton

A new supersymmetric standard model based on N=1 supergravity is constructed, aiming at natural explanation for the proton stability without invoking an ad hoc discrete symmetry through R parity. The proton is protected from decay by an extra U(1) gauge symmetry. Particle contents are necessarily increased to be free from anomalies, making it possible to incorporate the superfields for right-handed neutrinos and an SU(2)-singlet Higgs boson. The vacuum expectation value of this Higgs boson, which induces spontaneous breakdown of the U(1) symmetry, yields large Majorana masses for the right-handed neutrinos, leading to small masses for the ordinary neutrinos. The linear coupling of SU(2)-doublet Higgs superfields, which is indispensable to the superpotential of the minimal supersymmetric standard model, is replaced by a trilinear coupling of the Higgs superfields, so that there is no mass parameter in the superpotential. The energy dependencies of the model parameters are studied, showing that gauge symmetry breaking is induced by radiative corrections. Certain ranges of the parameter values compatible with phenomena at the electroweak energy scale can be derived from universal values of masses-squared and trilinear coupling constants for scalar fields at a very high energy scale.Comment: 32 pages, Revtex, 7 figure

A Supersymmetric Model with an Extra U(1) Gauge Symmetry

In the standard model the proton is protected from decay naturally by gauge symmetries, whereas in the ordinary minimal supersymmetric standard model an ad hoc discrete symmetry is imposed for the proton stability. We present a new supersymmetric model in which the proton decay is forbidden by an extra U(1) gauge symmetry. Particle contents are necessarily increased to be free from anomalies, incorporating right-handed neutrinos. Both Dirac and Majorana masses are generated for neutrinos, yielding non-vanishing but small masses. The superpotential consists only of trilinear couplings and the mass parameter $\mu$ of the minimal model is induced by spontaneous breaking of the U(1) symmetry.Comment: 10 pages, Revte

The μ\mu problem, and B and L Conservation with a Discrete Gauge R Symmetry

We examine in a generic context how the $\mu$ problem can be resolved by means of a spontaneously broken gauge symmetry. We then focus on the new scheme based on a discrete gauge R symmetry which is spontaneously broken by nonperturbative hidden sector dynamics triggering supersymmetry breaking also. The possibility to suppress the dangerous baryon and/or lepton number violating interactions by means of this discrete R symmetry is examined also together with some phenomenological consequences.Comment: 13 pages, RevTex, no figure