Commentary : the effects of inflammation, aging, and oxidative stress on the pathogenesis of Type II Diabetes

Type II Diabetes Mellitus (T2DM) is a high-risk metabolic condition associated with high mortality due to hyperglycemia. Many studies have focused on how inflammation, aging, or oxidative stress influences the pathogenesis of T2DM. The functional anomalies of the pancreatic beta cells attribute to insulin resistance which is the primary cause of T2DM manifestations and complications. This is evidenced in polymorphism in the TNF-α gene which inhibits insulin production, metabolism, and utilization during T2DM development. The dysregulation of insulin signaling involves multiple pathways. Various factors such as epigenetics, oxygen radicals, and glucolipotoxicity are implicated in the pathogenesis. Low-grade inflammation mediated by pro-inflammatory cytokines and chemokines such as interleukin-1 attack peripheral tissues and mediates the activation of critical pathways involved in T2DM pathogenesis via transcriptional factors. The core factor resulting in inflammation is hyperglycemia. The result is the release of inflammatory mediators which then affect neurons in the nervous system and alter microvascular and enzymatic pathways to elicit severe complications such as neuropathy. Oxidative stress and inflammation share an intertwined relationship in the pathogenesis of T2DM. High levels of reactive oxygen species increase the level of DNA damage markers and expose pancreatic beta-cell lines to dysregulation through reduced expression of the insulin gene. The link between the interaction of oxidative stress and inflation in the human body increases the level of interleukin-6 which triggers superoxide radicles and oxidative stressors increase which have been shown to affect free fatty acids metabolism inversely Finally, the aspect of cellular senescence in adipocytes and pancreatic beta cells explain why age is a critical factor in T2DM pathogenesis. Overall, the three factors discussed have a crucial role in T2DM disease states, progressions, and complications

Omega 3 versus Omega 6 polyunsaturated fatty acids in cardio-metabolic health

Background: Cardiometabolic diseases like type 2 diabetes, metabolic syndrome, heart failure, and other cardiovascular complications are the leading cause of mortality and morbidity across the globe. These conditions are directly attributed to modifiable behaviors such as sedentary activity, poor diet, excessive consumption of alcohol, or smoking. Efforts aimed towards their prevention and management are, therefore, not only essential in the accomplishment of the healthy populations but also for eliminating the associated cost and health burdens. Dietary change is an important approach to the promotion of cardiometabolic health. Omega 3 (C20–22 ω 3) polyunsaturated fatty acids have pleiotropic effects on the functioning of cells, control inflammatory factors and cellular events in vascular endothelial cells and cardiomyocytes. The hypolipemic, anti-arrhythmic, and anti-inflammatory properties of fatty acids offer cardioprotection. Government agencies and national heart associations recommend increased consumption of omega 3 polyunsaturated fatty acids (PUFA) supplements and fish to prevent cardiometabolic diseases. Purpose of the Study: The purpose of this study is to investigate the role played by ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic health. Methods: The research study searched databases such as MEDLINE®, Embase, PsycINFO, CINAHL® and the Cochrane Library for relevant research studies evaluating the function/benefits of polyunsaturated fatty acids particularly ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic functions published between 2011 and 2020. A total of 77 research studies were identified and used in the meta-analysis. Results: Results from the meta-analysis indicated that polyunsaturated fatty acids lower the risk for cardiovascular disease by limiting inflammation of blood vessels, reducing thrombosis, increasing levels of high-density lipoproteins, reducing levels of low-density lipoproteins, and reducing risk factors associated with hypertension. Conclusion. Given the benefits of polyunsaturated fatty acids lower the risk for cardiovascular diseases indicted in the meta-analysis. Therefore, human diets must contain the required amounts of PUFA due to the associated benefits. Keywords: Omega-3, Omega-6, Polyunsaturated fatty acids, Cardiometabolic healt

Keselamatan terhadap Resiko Kebakaran pada Bangunan Ruko di Kota Makassar

Penelitian bertujuan untuk (1) mengidentifikasi ketersediaan unsur keselamatan kebakaran pada bangunan ruko standar maupun yang sudah mengalami Perubahan di kota Makassar dan (2) mendapatkan arahan dan solusi standar unsur keselamatan terhadap resiko kebakaran pada bangunan ruko yang laik diaplikasikan di masa mendatang khususnya di kota Makassar. Penelitian mengambil sampel beberapa kluster ruko di koridor jalan kota Makassar. Penentuan kasus menggunakan teknik nonprobability sampling yang dilakukan secara purposif terhadap 87 unit ruko dari 3 kluster yang dibangun oleh pengembang (kluster jalan Pengayoman, kluster jalan Perintis Kemerdekaan, kluster jalan Talasalapang) dan 3 unit ruko yang dibangun sendiri oleh pemiliknya di jalan Todopuli Raya, jalan Adiyaksa Baru, dan jalan Abdullah Dg. Sirua berdasarkan kriteria-kriteria yang telah ditetapkan. Data dianalisis dengan menggunakan analisis deskriptif kualitatif. Hasil penelitian menunjukkan bahwa ketersediaan unsur keselamatan terhadap resiko kebakaran pada bangunan ruko yang dibangun oleh pengembang memiliki nilai rata-rata dengan kategori “cukup”. Ketersediaan unsur keselamatan terhadap resiko kebakaran pada bangunan ruko yang dibangun sendiri oleh pemiliknya justru memiliki nilai rata-rata dengan kategori “baik”. Desain bangunan ruko dimasa yang akan datang harus menerapkan standar sarana penyelamatan dengan berbagai alternatif jalur keselamatan untuk mencegah jatuhnya korban jiwa saat kebakaran serta unsur keselamatan lainnya (kelengkapan tapak, proteksi pasif dan aktif). Kata Kunci : Keselamatan, Ruko (Rumah Toko), Kebakaran, Makassa

PENGALEH PUKOL Komposisi Karawitan Kesenian Kompang Di Desa Concong Luar Kabupaten Indragiri Hilir

ABSTRACTKompang art in Concong Luar Village, Concong Subdistrict, Indragiri Hilir Regency, in the kompang pattern game on the long pukol song, the kompang pattern is played with manners and the musical structure of the work is still underdeveloped. From this musical case, the artist got the idea to develop a kompang transition pattern that is still underdeveloped to be varied both in terms of sound color and rhythm pattern. the creator was inspired by the transition pattern in the long pukol song. Pengaleh Pukol is a term that the author adopted from the mention of the transitional pattern in the long pukol song. From the kompang transition pattern, the artist develops transitional patterns in the kompang found in the long pukol song with a new composition that is different from the tradition. Based on the artist's observations of the transitional pattern, this has still not been worked out in a variety of ways, so the idea arose from the artist to work on the Riau Kompang art into compositional work with a traditional approach, with several instruments such as, rabano, kompang, and flying as a form of developing work as well as a touch of taste. varied and unobtrusive

Pengaruh Motivasi Terhadap Kinerja Pegawai Badan Kepegawaian Dan Diklat Daerah Kabupaten Mamuju Utara

This study aims to determine; (1) large simultaneous influence of motivation on employee performance Personnel Board and Regional Training North Mamuju regency; (2) the influence of motivation partially on employee performance Personnel Board and Regional Training North Mamuju regency. The theory of motivation used in this study using the theory of Maslow (1908-1970), namely "Hirarchy of Needs" or often referred to as a variable needs theory X and theory Moh performance. As'ad as a variable Y. This type of research is quantitative. This study population employee Personnel Board and Regional Training North Mamuju regency totaling 46 people who were taken using census techniques so that the total sample of 46 respondents. Data collection techniques including observation, questionnaire, and documentation, while data analysis techniques using simple linear regression. The results showed; (1) the magnitude of the simultaneous influence of motivation on employee performance Personnel Board and Regional Training North Mamuju regency is determined by physiological needs, security needs, social needs, esteem needs and self-actualization needs, with the influence of 63.6% and a strong relationship ; (2) the influence of motivation partially on employee performance Personnel Board and Regional Training Regency of North Mamuju determined by the influence of physiological needs for performance, the effect of the security needs of the performance, the influence of social needs on performance, influence the need rewards to performance, and the effect of actualization needs diriterhadap performance

Pembuatan Aplikasi Pendukung Keputusan Beasiswa Tidak Mampu dengan Metode Naive Bayes

Aplikasi Pendukung Keputusan Beasiswa Tidak Mampu dengan metode Naive Bayes ini di buat menggunakan bahasa pemrograman PHP dan database MySQL. Aplikasi ini dapat membantu Biro Administrasi Akadmik dan Kemahasiswaan Univeristas Muhammadiyah Bengkulu dalam menyelesaikan pekerjaan khususnya pada pengelolaan data beasiswa PPA dan BBM dan juga pengarsipan data. Aplikasi ini dapat mendukung pengambilan keputusan pada calon penerima beasiswa PPA dan BBM, dalam pengambilan keputusan Aplikasi menggunakan empat kriteria yaitu, penghasilan orang tua, ipk, jumlah sks dan aktif organisasi

Learning: Javanese Students, Non-Javanese Students

Learning is an important activity that must be done by students. If you want to know a course material or information, of course, students must look for it. One of the ways to look for something is by learning. Students at Kanjuruhan University come from various regions in Indonesia. The researcher divided the students into two large groups, namely students from Java and Non-Java. Both have unique and different ways to absorb information. Their learning methods are affected by the background of their respective regions. Each lecturer should know the background of each student, especially about the origin of the region. The results of this study indicate that lecturers are better of using a descriptive approach when explaining material to Javanese students. Meanwhile, when lecturers explain the material to students non-Java it is better to use a prescriptive approach. In this way the lecturer will find it easier to explain the lecture material that will be delivered. In addition, students will also have no difficulty in absorbing lecture material delivered.   Keywords: Prescriptive, Descriptive, Javanese Students, Non-Javanese student

Kualitas Pelayanan pada Kantor Pelayanan Perizinan dan Penanaman Modal Kabupaten Barru

: Pelayanan yang berkualitas merupakan pelayanan yang diberikan kepada pelanggan sesuai dengan standar pelayanan, akan tetapi pelayanan publik ternyata seringkali mengecewakan dibandingkan memuaskan. Oleh karena itu, penelitian ini bertujuan untuk mengetahui dan menjelaskan kualitas pelayanan pada Kantor Pelayanan Perizinan dan Penanaman Modal Kabupaten Barru. Metode penelitiannya adalah survai dengan desain deskriptif. Teknik pengumpulan datanya menggunakan angket, wawancara, observasi, dan telaah dokumen. Data dianalisis secara deskriptif interpretatif. Hasil penelitian menunjukkan bahwa kualitas pelayanan di Kantor Pelayanan Perizinan dan Penanaman Modal yang diberikan pada masyarakat berada pada kategori berkualitas. Hal tersebut dapat dilihat dari rata-rata skor untuk keseluruhan sub variabel yaitu 3,86 yang apabila didasarkan pada kriteria dan rentang skala yang ada termasuk dalam kategori berkualitas. Variabel penelitian digambarkan dengan menggunakan 10 sub variabel yaitu ketepatan pelayanan, akurasi pelayanan, kesopanan dan keramahan, tanggung jawab, kelengkapan, kemudahan mendapatkan pelayanan, variasi model pelayanan, pelayanan pribadi, Kenyamanan, serta atribut pendukung. Hasil penelitian menunjukkan bahwa dari 10 indikator tersebut terdapat 1 indikator berada dalam kategori kurang berkualitas yakni ketepatan waktu.Kata kunci : Kualitas pelayanan, Perizinan, Penanaman modal. Abstract : Quality services are the services provided to the customer in accordance with the standards of services, but public service is often disappointing rather than satisfying. Therefore, this study aims to identify and to define the quality of services in Licensing and Investment Services Office of Barru Regency. The research method was a descriptive design survey. The technique of collecting data was using questionnaires. Data was analyzed descriptively interpretative. The results shows that the quality of services in the Licensing and Investment Services Office to the community is categorized good quality. This can be seen from the average score of the entire sub-variables at 3.86 that based on the criterion and existing scale ranges can be categorized good quality. The research variables described by using 10 sub-variables that are services target, accuracy service, courtesy and hospitality, responsibility, completeness, access to services, the variation model of service, personal care, comfort and support attributes. The research findings show that of the 10 indicators, there is one indicator that has been categorized as less quality, that is punctuality.Keywords : Service quality, Licensing, Investment