Links of adversity in childhood with mental and physical health outcomes: A systematic review of longitudinal mediating and moderating mechanisms

Hales, G. K., Saribaz, Z. E., Debowska, A., & Rowe, R., Links of adversity in childhood with mental and physical health outcomes: A systematic review of longitudinal mediating and moderating mechanisms, Trauma, Violence, and Abuse (Journal Volume Number and Issue Number) pp. xx-xx. Copyright © [2022] (The Authors). Reprinted by permission of SAGE Publications.Adverse childhood experiences (ACEs) have been associated with causes of early death, addiction, mental illness, and poor health. However, studies investigating underlying mechanisms often rely on cross-sectional data or inappropriate study designs. To prevent the negative sequelae associated with ACEs, it is imperative to understand the mechanisms underlying the prospective relationship. The aim of this present review was to provide a synthesis and critical evaluation of the literature regarding the mechanisms underlying this relationship. A search in SCOPUS, MedLine via Ovid, PsycINFO via Ovid, and Web of Science was performed. Studies that utilised a prospective design assessing ACEs in childhood or adolescence, outcomes in adulthood, and analysed either a mediating or moderating relationship were included, unless the study relied on informant report or official records to assess childhood maltreatment types of ACEs. Twenty-two studies examining a longitudinal mediation or moderation were included in a systematic review. A review of the studies found links to psychopathology, delinquent and problem behaviours, poor physical health, and poor socioeconomic outcomes. A clear image of underlying mechanisms is not forthcoming due to (a) poor study design in relation to assessing longitudinal mechanisms, and (b) heterogeneity in the adversities, mechanisms, and outcomes assessed. Based on the review, several gaps and limitations are highlighted and discussed

Effects of decreased dietary roughage concentration on energy metabolism and nutrient balance in finishing beef cattle

The optimal roughage concentration required in feedlot diets changes continuously for many reasons such as source, availability, price, and interaction with other ingredients in the diet. Wet distillers grains and solubles (WDGS) are common in finishing diets and they contain relatively high amounts of fiber compared with other grains they replace. Therefore, concentration of roughage could be altered when WDGS are included in feedlot diets. There has been very little data published regarding the effects of roughage concentration on energy metabolism and nutrient balance in beef steers. Therefore, the effects of roughage concentration in dryrolled corn (DRC)–based diets containing 25% WDGS were evaluated in 8 steers (BW = 362 ± 3.71 kg) using a replicated Latin square. Data were analyzed with the fixed effects of dietary treatment and period and random effects of square and steer within square were included in the model. Diets consisted of 25% WDGS and the balance being DRC and coarsely ground alfalfa hay (AH) replacing corn at 2% (AH-2), 6% (AH-6), 10% (AH-10), and 14% (AH-14) of dietary dry matter. As a proportion of GE intake, fecal energy loss increased linearly (P = 0.02), and DE decreased linearly (P = 0.02) as dietary level of AH increased. Methane energy loss, as a proportion of GE intake, increased linearly (P \u3c 0.01) and ME decreased linearly (P \u3c 0.01) as dietary concentration of AH increased. Heat production tended (P = 0.10) to decrease reaching a minimum of 10% AH and increased from 10 to 14% AH inclusion. Moreover, as a proportion of GE intake, retained energy (RE) decreased (P \u3c 0.01) as AH level increased in the diet. Reasons for the decrease in RE are 1) the increase in fecal energy loss that is associated with decreased ruminal digestibility of NDF when AH replaced DRC and the shift in ruminal VFA produced, 2) the decreased energy available for animal retention when NDF increased linearly as AH increased in the diet, and 3) the methane and heat energy associated with digestion of the fibrous portion of the AH. Neutral detergent fiber and OM excretion also increased linearly (P \u3c 0.01) with increasing AH in the diet. The increased NDF and OM excretion were likely caused by the difference in digestibility of AH and DRC

Effects of decreased dietary roughage concentration on energy metabolism and nutrient balance in finishing beef cattle

The optimal roughage concentration required in feedlot diets changes continuously for many reasons such as source, availability, price, and interaction with other ingredients in the diet. Wet distillers grains and solubles (WDGS) are common in finishing diets and they contain relatively high amounts of fiber compared with other grains they replace. Therefore, concentration of roughage could be altered when WDGS are included in feedlot diets. There has been very little data published regarding the effects of roughage concentration on energy metabolism and nutrient balance in beef steers. Therefore, the effects of roughage concentration in dryrolled corn (DRC)–based diets containing 25% WDGS were evaluated in 8 steers (BW = 362 ± 3.71 kg) using a replicated Latin square. Data were analyzed with the fixed effects of dietary treatment and period and random effects of square and steer within square were included in the model. Diets consisted of 25% WDGS and the balance being DRC and coarsely ground alfalfa hay (AH) replacing corn at 2% (AH-2), 6% (AH-6), 10% (AH-10), and 14% (AH-14) of dietary dry matter. As a proportion of GE intake, fecal energy loss increased linearly (P = 0.02), and DE decreased linearly (P = 0.02) as dietary level of AH increased. Methane energy loss, as a proportion of GE intake, increased linearly (P \u3c 0.01) and ME decreased linearly (P \u3c 0.01) as dietary concentration of AH increased. Heat production tended (P = 0.10) to decrease reaching a minimum of 10% AH and increased from 10 to 14% AH inclusion. Moreover, as a proportion of GE intake, retained energy (RE) decreased (P \u3c 0.01) as AH level increased in the diet. Reasons for the decrease in RE are 1) the increase in fecal energy loss that is associated with decreased ruminal digestibility of NDF when AH replaced DRC and the shift in ruminal VFA produced, 2) the decreased energy available for animal retention when NDF increased linearly as AH increased in the diet, and 3) the methane and heat energy associated with digestion of the fibrous portion of the AH. Neutral detergent fiber and OM excretion also increased linearly (P \u3c 0.01) with increasing AH in the diet. The increased NDF and OM excretion were likely caused by the difference in digestibility of AH and DRC

Tractographic and Microstructural Analysis of the Dentato-Rubro-Thalamo-Cortical Tracts in Children Using Diffusion MRI

The dentato-rubro-thalamo-cortical tract (DRTC) is the main outflow pathway of the cerebellum, contributing to a finely balanced corticocerebellar loop involved in cognitive and sensorimotor functions. Damage to the DRTC has been implicated in cerebellar mutism syndrome seen in up to 25% of children after cerebellar tumor resection. Multi-shell diffusion MRI (dMRI) combined with quantitative constrained spherical deconvolution tractography and multi-compartment spherical mean technique modeling was used to explore the frontocerebellar connections and microstructural signature of the DRTC in 30 healthy children. The highest density of DRTC connections were to the precentral (M1) and superior frontal gyri (F1), and from cerebellar lobules I-IV and IX. The first evidence of a topographic organization of anterograde projections to the frontal cortex at the level of the superior cerebellar peduncle (SCP) is demonstrated, with streamlines terminating in F1 lying dorsomedially in the SCP compared to those terminating in M1. The orientation dispersion entropy of DRTC regions appears to exhibit greater contrast than that shown by fractional anisotropy. Analysis of a separate reproducibility cohort demonstrates good consistency in the dMRI metrics described. These novel anatomical insights into this well-studied pathway may prove to be of clinical relevance in the surgical resection of cerebellar tumors

The ATLAS Survey of the CDFS and ELAIS-S1 Fields

The first phase of the ATLAS (Australia Telescope Large Area Survey) project surveyed a total 7 square degrees down to 30 micro Jy rms at 1.4 GHz and is the largest sensitive radio survey ever attempted. We report on the scientific achievements of ATLAS to date and plans to extend the project as a path finder for the proposed EMU (Evolutionary map of the Universe) project which has been designed to use ASKAP (Australian Square Kilometre Array Pathfinder).Comment: 4 pages, 3 figure

Use of indirect calorimetry to evaluate utilization of energy in lactating Jersey dairy cattle consuming common coproducts

The use of coproducts as an alternative feed source is a common practice when formulating dairy rations. A study using 12 multiparous (79 ± 16 d in milk; mean ± standard deviation) lactating Jersey cows was conducted over 5 mo to evaluate the effects of dried distillers grains with solubles (DDGS) or canola meal on milk and gas production. A replicated 4 × 4 Latin square design was used to compare 4 dietary treatments. Treatments comprised a control (CON) containing no coproducts, a treatment diet containing 10% (dry matter basis) lowfat DDGS (LFDG), a treatment diet containing 10% high-fat DDGS (HFDG), and a 10% canola meal (CM) treatment. The crude fat content of the LFDG, HFDG, and CM treatments was 6.05 ± 0.379, 10.0 ± 0.134, and 3.46 ± 0.085%, respectively. Coproducts were included in partial replacement for corn and soybean meal. Indirect headbox-style calorimeters were used to estimate heat production. Dry matter intake and milk yield were similar between all treatments, averaging 17.4 ± 0.56 kg/d and 24.0 ± 0.80 kg, respectively. Milk urea N was affected by treatment and was highest in CON (20.6 mg/dL; 18.0, 19.9, and 18.1 ± 0.62 mg/dL in LFDG, CM, and HFDG, respectively). Heat production per unit of metabolic body weight tended to be affected by treatment and was lowest for CON, and diets containing coproducts were not different (192, 200, 215, and 204 ± 5.91 kcal/kg of metabolic body weight for CON, LFDG, CM, and HFDG, respectively). The concentration of metabolizable energy was affected by dietary treatment; specifically, HFDG did not differ from CON but was greater than LFDG and CM (2.58, 2.46, 2.29, and 2.27 ± 0.09 Mcal/kg for HFDG, CON, LFDG, and CM, respectively). The concentration of net energy balance (milk plus tissue) tended to be affected by dietary treatment; HFDG did not differ from either CON or LFDG, but it was higher than CM (1.38, 1.36, 1.14, and 1.06 ± 0.11 Mcal/kg for HFDG, CON, LFDG, and CM, respectively). Results of this study indicate that milk production and dry matter intake were not affected by feeding common coproducts and that differences may result in whole-animal energy use; fat content of DDGS is a major factor affecting this

Radio Frequency Spectra of 388 Bright 74 MHz Sources

As a service to the community, we have compiled radio frequency spectra from the literature for all sources within the VLA Low Frequency Sky Survey (VLSS) that are brighter than 15 Jy at 74 MHz. Over 160 references were used to maximize the amount of spectral data used in the compilation of the spectra, while also taking care to determine the corrections needed to put the flux densities from all reference on the same absolute flux density scale. With the new VLSS data, we are able to vastly improve upon previous efforts to compile spectra of bright radio sources to frequencies below 100 MHz because (1) the VLSS flux densities are more reliable than those from some previous low frequency surveys and (2) the VLSS covers a much larger area of the sky (declination >-30 deg.) than many other low frequency surveys (e.g., the 8C survey). In this paper, we discuss how the spectra were constructed and how parameters quantifying the shapes of the spectra were derived. Both the spectra and the shape parameters are made available here to assist in the calibration of observations made with current and future low frequency radio facilities.Comment: Accepted to ApJ

Exploring the dark accelerator HESS J1745-303 with Fermi Large Area Telescope

We present a detailed analysis of the gamma-ray emission from HESS J1745-303 with the data obtained by the Fermi Gamma-ray Space Telescope in the first ~29 months observation.The source can be clearly detected at the level of ~18-sigma and ~6-sigma in 1-20 GeV and 10-20 GeV respectively. Different from the results obtained by the Compton Gamma-ray Observatory, we do not find any evidence of variability. Most of emission in 10-20 GeV is found to coincide with the region C of HESS J1745-303. A simple power-law is sufficient to describe the GeV spectrum with a photon index of ~2.6. The power-law spectrum inferred in the GeV regime can be connected to that of a particular spatial component of HESS J1745-303 in 1-10 TeV without any spectral break. These properties impose independent constraints for understanding the nature of this "dark particle accelerator".Comment: 8 pages, 3 figures, 1 table, accepted for publication in Ap

Comparison Between Diffusion-Weighted MRI and I-123-mIBG Uptake in Primary High-Risk Neuroblastoma

Background: High-risk neuroblastoma (HR-NB) has a variable response to preoperative chemotherapy. It is not possible to differentiate viable vs. nonviable residual tumor before surgery. Purpose: To explore the association between apparent diffusion coefficient (ADC) values from diffusion-weighted magnetic resonance imaging (DW-MRI), 123I-meta-iodobenzyl-guanidine (123I-mIBG) uptake, and histology before and after chemotherapy. Study Type: Retrospective. Subjects: Forty patients with HR-NB. Field Strength/Sequence: 1.5T axial DW-MRI (b = 0,1000 s/mm2 ) and T2-weighted sequences. 123I-mIBG scintigraphy planar imaging (all patients), with additional 123I-mIBG single-photon emission computed tomography / computerized tomography (SPECT/CT) imaging (15 patients). Assessment: ADC maps and 123I-mIBG SPECT/CT images were coregistered to the T2-weighted images. 123I-mIBG uptake was normalized with a tumor-to-liver count ratio (TLCR). Regions of interest (ROIs) for primary tumor volume and different intratumor subregions were drawn. The lower quartile ADC value (ADC25prc) was used over the entire tumor volume and the overall level of 123I-mIBG uptake was graded into avidity groups. Statistical Tests: Analysis of variance (ANOVA) and linear regression were used to compare ADC and MIBG values before and after treatment. Threshold values to classify tumors as viable/necrotic were obtained using ROC analysis of ADC and TLCR values. Results: No significant difference in whole-tumor ADC25prc values were found between different 123I-mIBG avidity groups pre- (P = 0.31) or postchemotherapy (P = 0.35). In the “intratumor” analysis, 5/15 patients (prechemotherapy) and 0/14 patients (postchemotherapy) showed a significant correlation between ADC and TLCR values (P < 0.05). Increased tumor shrinkage was associated with lower pretreatment tumor ADC25prc values (P < 0.001); no association was found with pretreatment 123I-mIBG avidity (P = 0.17). Completely nonviable tumors had significantly lower postchemotherapy ADC25prc values than tumors with >10% viable tumor (P < 0.05). Both pre- and posttreatment TLCR values were significantly higher in patients with >50% viable tumor than those with 10–50% viable tumor (P < 0.05). Data Conclusion: 123I-mIBG avidity and ADC values are complementary noninvasive biomarkers of therapeutic response in HR-NB. Level of Evidence: 4. Technical Efficacy Stage: 3