Evaluate different nanoparticles into dental restorative materials: A systematic review and meta-analysis

Background and aim: The purpose of this study was to evaluate different nanoparticles in dental restorative materials. Method: Databases of PubMed, Scopus, Web of Science, EBSCO, ISI Web of Knowledge, and Embase were searched for systematic literature between 2012 to July 2022.  Data analysis was performed using STATA/MP V17 software. 95% confidence interval for mean differences or Hedges' g (a measure of effect size) with fixed effect model and Inverse-variance method were calculated. Result: In the initial review, duplicate studies were eliminated and abstracts of 151 studies were reviewed, the full text of 42 studies was reviewed by two authors, and finally, 11 studies were selected. Hedges' g of changes to the bacterial activity of dental restorative materials for silver nanoparticles was –1.90 (Hedges' g -1.90 95% CI -2.52, -1.28), for calcium phosphate nanoparticles, was –0.64 (Hedges' g -0.64 95% CI -2.03, 0.94), for CaP/Ag nanoparticles was –0.44 (Hedges' g -0.44 95% CI –1.83, 0.94) and Hedges' g of changes to the bacterial activity of dental restorative materials for Titanium dioxide nanoparticles was –2.41 (Hedges' g -2.41 95% CI –3.11, -1.72).&nbsp