Review of Factors Related to the Thyroid Cancer Epidemic

Thyroid cancer is the most common endocrine cancer, of which the incidence has dramatically increased worldwide in the past few decades. The reasons for the observed rapid increase still are not fully understood, but evidence suggests that overdiagnosis, with the advancement in detection methods and screening policies, is not the sole driver of the substantial increase of the incidence. However, the effect of environmental/lifestyle factors remains speculative other than that of radiation exposure at a young age. This review tries to give a balanced view of debated factors leading to the thyroid cancer epidemic, to offer some alternatives in understanding the controversies, and to suggest potential directions in the search of modifiable risk factors to help reduce thyroid cancer

The effect of randomness for dependency map on the robustness of interdependent lattices

ACKNOWLEDGMENTS This paper is supported by the National Natural Science Foundation of China (Grant Nos. 61573067 and 61472045), the Beijing Higher Education Young Elite Teacher Project (Grant No. YETP0449), the Asia Foresight Program under NSFC Grant (Grant No. 61411146001), and the Beijing Natural Science Foundation (Grant No. 4142016).Peer reviewedPublisher PD

Automatic Scaling of Internet Applications for Cloud Computing Services

Abstract-Many Internet applications can benefit from an automatic scaling property where their resource usage can be scaled up and down automatically by the cloud service provider. We present a system that provides automatic scaling for Internet applications in the cloud environment. We encapsulate each application instance inside a virtual machine (VM) and use virtualization technology to provide fault isolation. We model it as the Class Constrained Bin Packing (CCBP) problem where each server is a bin and each class represents an application. The class constraint reflects the practical limit on the number of applications a server can run simultaneously. We develop an efficient semi-online color set algorithm that achieves good demand satisfaction ratio and saves energy by reducing the number of servers used when the load is low. Experiment results demonstrate that our system can improve the throughput by 180% over an open source implementation of Amazon EC2 and restore the normal QoS five times as fast during flash crowds. Large scale simulations demonstrate that our algorithm is extremely scalable: the decision time remains under 4 s for a system with 10 000 servers and 10 000 applications. This is an order of magnitude improvement over traditional application placement algorithms in enterprise environments

Induction of CCL8/MCP-2 by mycobacteria through the activation of TLR2/PI3K/Akt signaling pathway.

Pleural tuberculosis (TB), together with lymphatic TB, constitutes more than half of all extrapulmonary cases. Pleural effusions (PEs) in TB are representative of lymphocytic PEs which are dominated by T cells. However, the mechanism underlying T lymphocytes homing and accumulation in PEs is still incompletely understood. Here we performed a comparative analysis of cytokine abundance in PEs from TB patients and non-TB patients by protein array analysis and observed that MCP-2/CCL8 is highly expressed in the TB-PEs as compared to peripheral blood. Meanwhile, we observed that CCR5, the primary receptor used by MCP-2/CCL8, is mostly expressed on pleural CD4(+) T lymphocytes. Furthermore, we found that infection with either Mycobacterium bovis Bacillus Calmette-Guérin (BCG) or Mycobacterium tuberculosis H37Rv induced production of MCP-2/CCL8 at both transcriptional and protein level in Raw264.7 and THP-1 macrophage cells, mouse peritoneal macrophages as well as human PBMC monocyte-derived macrophages (MDMs). The induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt and p38 signaling pathway. We conclude that accumulation of MCP-2/CCL8 in TB-PEs may function as a biomarker for TB diagnosis

Adaptive Synchronization of Complex Dynamical Multilinks Networks with Similar Nodes

This paper studies the synchronization of complex dynamical networks with multilinks and similar nodes. The dynamics of all the nodes in the networks are impossible to be completely identical due to the differences of parameters or the existence of perturbations. Networks with similar nodes are universal in the real world. In order to depict the similarity of the similar nodes, we give the definition of the minimal similarity of the nodes in the network for the first time. We find the threshold of the minimal similarity of the nodes in the network. If the minimal similarity of the nodes is bigger than the threshold, then the similar nodes can achieve synchronization without controllers. Otherwise, adaptive synchronization method is adopted to synchronize similar nodes in the network. Some new synchronization criteria are proposed based on the Lyapunov stability theory. Finally, numerical simulations are given to illustrate the feasibility and the effectiveness of the proposed theoretical results

Robust and Intensity-Dependent Synaptic Inhibition Underlies the Generation of Non-monotonic Neurons in the Mouse Inferior Colliculus

Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of intensity encoding. Although previous researchers have hinted at the importance of inhibitory effects on the formation of non-monotonic neurons, the specific underlying synaptic mechanisms in the ICC are still unclear. Therefore, we applied the in vivo whole-cell voltage-clamp technique to record the excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) in the ICC neurons, and compared the effects of excitation and inhibition on the membrane potential outputs. We found that non-monotonic neuron responses could not only be inherited from the lower nucleus but also be created in the ICC. By integrating with a relatively weak IPSC, approximately 35% of the monotonic excitatory inputs remained in the ICC. In the remaining cases, monotonic excitatory inputs were reshaped into non-monotonic outputs by the dominating inhibition at high intensity, which also enhanced the non-monotonic nature of the non-monotonic excitatory inputs

Interfacial electronic structure at the CH3NH3PbI3/MoOx interface

Interfacial electronic properties of the CH3NH3PbI3 (MAPbI3)/MoOx interface are investigated using ultraviolet photoemission spectroscopy and X-ray photoemission spectroscopy. It is found that the pristine MAPbI3 film coated onto the substrate of poly (3,4-ethylenedioxythiophene) poly(styrenesulfonate)/indium tin oxide by two-step method behaves as an n-type semiconductor, with a band gap of ~1.7 eV and a valence band edge of 1.40 eV below the Fermi energy (EF). With the MoOx deposition of 64A ° upon MAPbI3, the energy levels of MAPbI3 shift toward higher binding energy by 0.25 eV due to electron transfer from MAPbI3 to MoOx. Its conduction band edge is observed to almost pin to the EF, indicating a significant enhancement of conductivity. Meanwhile, the energy levels of MoOx shift toward lower binding energy by ~0.30 eV, and an interface dipole of 2.13 eV is observed at the interface of MAPbI3/MoOx. Most importantly, the chemical reaction taking place at this interface results in unfavorable interface energy level alignment for hole extraction. A potential barrier of ~1.36 eV observed for hole transport will impede the hole extraction from MAPbI3 to MoOx. On the other hand, a potential barrier of ~0.14 eV for electron extraction is too small to efficiently suppress electrons extracted from MAPbI3 to MoOx. Therefore, such an interface is not an ideal choice for hole extraction in organic photovoltaic devices

The effect of water temperature on the pathogenicity of decapod iridescent virus 1 (DIV1) in Litopenaeus vannamei

Decapod iridescent virus 1 (DIV1) has caused huge losses to the shrimp breeding industry in recent years as a new shrimp virus. In this study, white leg shrimp, Litopenaeus vannamei, were cultured at different temperatures (26 ± 1 °C and 32 ± 1 °C) and the same salinity, then infected with DIV1 by intramuscular injection to determine the effects of water temperature on viral infection. The DIV1 copy counts in the gills, hepatopancreas, pleopods, intestines, and muscles of L. vannamei were measured in samples collected at 6, 12, and 24 h post-infection (hpi), and the survival rate of L. vannamei was assessed every 6 h after infection. At 96 hpi, the survival rates of L. vannamei in the high (32 ± 1 ℃) and standard (26 ± 1 ℃) water temperature groups were 2.22% and 4.44%, respectively. The peak time of mortality in the high-water temperature group was 6 h earlier than in the standard water temperature group. After 24 hours of DIV1 infection, the DIV1 copy counts in the standard water temperature treatment group were significantly higher than those in the high-water temperature treatment group. The tissues with the highest virus copy counts in the standard and high-temperature groups were the intestines (2.9×1011 copies/g) and muscles (7.0×108 copies/g). The effect of temperature on the pathogenicity of DIV1 differs from that of other previously studied viruses, such as white spot syndrome virus, Taura syndrome virus, and infectious hypodermal and hematopoietic necrosis virus, because the high-water temperature did not mitigate the damage caused by DIV1 infection

Carbon monoxide poisoning deaths in Shanghai, China: A 10-year epidemiological and comparative study with the Wuhan sample

Abstract: Carbon monoxide (CO) poisoning is a common cause of death globally. However, CO poisoning deaths in the Mainland China are rarely studied. Therefore, this study aims to explore the incidence trend of CO poisoning deaths that occurred in Pudong for a 10-year period (2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014). Using official police data, a total of 139 CO poisoning events that resulted in the death of 176 victims are collected. By comparing the data from Shanghai with the previous one from Wuhan, this study presents the most up-to date information about CO poisoning deaths that happened in China. The result indicates that the CO poisoning death rate in the study area in China is in the low level around the globe. Features of fire-related CO poisoning deaths are similar between the two mega cities, but in nonfire-related CO poisoning deaths, there are some distinguishing regional features. This study also found that the CO poisoning suicides by burning coal or charcoal is increasing sharply in recent years, especially in considering about the higher rate of burning charcoal suicides in the regions around the Mainland China. Certain precautious should be taken to prevent the growing trend of coal or charcoal burning suicides in future