Deskripsi Motivasi Belajar Fisika Kelas X MIPA di SMA Negeri 4 Kota Jambi

Tujuan Penelitian: Penelitian ini bertujuan untuk mendeskripsikan motivasi belajar fisika siswa kelas X MIPA di SMA Negeri 4 Kota Jambi. Metodologi: Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif. Populasi penelitian ini adalah siswa kelas X MIPA di SMA Negeri 4 Kota Jambi semester ganjil tahun pelajaran 2020/2021 dan sampel penelitian berjumlah 90 siswa. Teknik pengambilan sampel dalam penelitian ini adalah total sampling. Instrumen penelitian yang digunakan adalah angket motivasi belajar fisika siswa. Jenis data penelitian ini adalah data kuantitatif. Teknik analisis data yang digunakan adalah analisis kuantitatif menggunakan statistik deskriptif. Temuan utama: Hasil penelitian ini menunjukkan bahwa motivasi belajar fisika siswa kelas X MIPA di SMA Negeri 4 Kota Jambi memiliki 3 kategori yaitu (1) cukup baik dengan skor 65.1 – 85.0 memiliki persentase 14.4 %; (2) baik dengan skor 85.1 – 105 memiliki persentase 63.3 %; (3) sangat baik dengan skor 105.1 – 125 memiliki presentase 22.2 %. Keterbaruan penelitian: Dapat disimpulkan bahwa motivasi belajar fisika siswa kelas X MIPA di SMA Negeri 4 Kota Jambi memiliki motivasi belajar yang baik atau tinggi. Sehingga dapat diketahui bahwa pengetahuan siswa dan keaktifan dalam belajar juga tinggi

Sorafenib Nanomicelles Effectively Shrink Tumors by Vaginal Administration for Preoperative Chemotherapy of Cervical Cancer

To investigate the potential of sorafenib (SF) in preoperative chemotherapy for cervical cancer to reduce tumor volume, sorafenib micelles (SF micelles) with good stability and high drug loading were designed. SF micelles were prepared by film hydration followed by the ultrasonic method. The results showed that the SF micelles were spherical with an average particle size of 67.18 ± 0.66 nm (PDI 0.17 ± 0.01), a considerable drug loading of 15.9 ± 0.46% (w/w%) and satisfactory stability in buffers containing plasma or not for at least 2 days. In vitro release showed that SF was gradually released from SF micelles and almost completely released on the third day. The results of in vitro cellular intake, cytotoxicity and proliferation of cervical cancer cell TC-1 showed that SF micelles were superior to sorafenib (Free SF). For intravaginal administration, SF micelles were dispersed in HPMC (SF micelles/HPMC), showed good viscosity sustained-release profiles in vitro and exhibited extended residence in intravaginal in vivo. Compared with SF micelles dispersed in N.S. (SF micelles/N.S.), SF micelles/HPMC significantly reduced tumor size with a tumor weight inhibition rate of 73%. The results suggested that SF micelles had good potential for preoperative tumor shrinkage and improving the quality life of patients

Sequential Release of Paclitaxel and Imatinib from Core–Shell Microparticles Prepared by Coaxial Electrospray for Vaginal Therapy of Cervical Cancer

To optimize the anti-tumor efficacy of combination therapy with paclitaxel (PTX) and imatinib (IMN), we used coaxial electrospray to prepare sequential-release core–shell microparticles composed of a PTX-loaded sodium hyaluronate outer layer and an IMN-loaded PLGA core. The morphology, size distribution, drug loading, differential scanning calorimetry (DSC), Fourier transform infrared spectra (FTIR), in vitro release, PLGA degradation, cellular growth inhibition, in vivo vaginal retention, anti-tumor efficacy, and local irritation in a murine orthotopic cervicovaginal tumor model after vaginal administration were characterized. The results show that such core–shell microparticles were of spherical appearance, with an average size of 14.65 μm and a significant drug-loading ratio (2.36% for PTX, 19.5% for IMN, w/w), which might benefit cytotoxicity against cervical-cancer-related TC-1 cells. The DSC curves indicate changes in the phase state of PTX and IMN after encapsulation in microparticles. The FTIR spectra show that drug and excipients are compatible with each other. The release profiles show sequential characteristics in that PTX was almost completely released in 1 h and IMN was continuously released for 7 days. These core–shell microparticles showed synergistic inhibition in the growth of TC-1 cells. Such microparticles exhibited prolonged intravaginal residence, a >90% tumor inhibitory rate, and minimal mucosal irritation after intravaginal administration. All results suggest that such microparticles potentially provide a non-invasive local chemotherapeutic delivery system for the treatment of cervical cancer by the sequential release of PTX and IMN